期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 159, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2023.114224
关键词
Spinal Cord Injury; Curcumin; Neuroprotective Mechanisms
Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. Curcumin, as the main active ingredient in turmeric, plays an important role in reducing inflammation and oxidation, protecting neurons, and ultimately reducing spinal cord injury by effectively curbing the process of secondary injury.
Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. After primary spinal cord injury, the secondary injury may occur in sequence, which is composed of ischemia and hypoxia, excitotoxicity, calcium overload, oxidative stress and inflammation, resulting in massive death of parenchymal cells in the injured area, followed by the formation of syringomyelia. Effectively curbing the process of secondary injury can promote nerve repair and improve functional prognosis. As the main active ingredient in turmeric, curcumin can play an important role in reducing inflammation and oxidation, protecting the neurons, and ultimately reducing spinal cord injury. This article reviews the effects of curcumin on the repair of nerve injury, with emphasis on the various mechanisms by which curcumin promotes the treatment of spinal cord injury.
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