☆ 4.7 Review

Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Summary: In the modern era, cancer can be controlled by chemotherapy treatment, and naturally derived molecules show potential as adjunctive therapies. Erinacine A, a metabolite from Hericium erinaceus, regulates signaling pathways and displays various chemotherapeutic applications by inducing apoptosis, reducing proliferation, invasiveness, generating oxidative stress, and arresting the cell cycle in cancer cells.

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Dietary supplements, vitamins and minerals as potential interventions against viruses: Perspectives for COVID-19

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INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (2022)

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Review Biochemistry & Molecular Biology

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Summary: PCOS is an endocrine-gynecology disorder affecting women of childbearing age, with incomplete understanding of its etiology and pathophysiology. Lifestyle modifications and alternative medicines are the preferred first-line therapy, and certain medications have shown potential for repurposing in PCOS. Further research and well-designed clinical trials are needed, as the current evidence is limited.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell Biology

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Summary: This review provides updated and critical scientific information about the traditional, nutritional, phytochemical, and biological activities of L. sativum (Garden cress). The study highlights the importance of L. sativum as an edible herb with a wide range of therapeutic properties and high nutritional values. Preclinical studies suggest that L. sativum and its bioactive compounds have potential clinical applications in cancer, liver protection, blood sugar regulation, and antioxidation.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

Hyssopus Essential Oil: An Update of Its Phytochemistry, Biological Activities, and Safety Profile

Javad Sharifi-Rad et al.

Summary: The genus Hyssopus is widely distributed and used as herbal remedies and flavoring agent. Its species are used in the treatment of various ailments and as additives. Important active constituents include beta-pinene, pinocamphone, and other compounds. Hyssopus extracts have potential antiviral and antifungal activities and play a crucial role in plasma membrane relaxation, cytotoxic, and sedative effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents

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Summary: Saffron, a valuable herbal plant, possesses various pharmacological activities such as antimicrobial, antioxidant, and antidepressant properties. It also serves as a natural food preservative. Further research is needed to identify new mechanisms of action and develop new pharmaceutical formulations.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide

Rajib Hossain et al.

Summary: This review summarizes the neuropharmacological properties of andrographolide (ANDRO) and highlights its potential therapeutic effects on neuro-inflammation, cerebral ischemia, Alzheimer's and Parkinson's diseases, multiple sclerosis, and brain cancer. ANDRO also shows the ability to enhance memory and learning in experimental animals without causing any toxicity in the brain.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Cell Biology

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Mohammed M. Alshehri et al.

Summary: This review comprehensively discusses the botanical characteristics, traditional use, geographic presence, and phytochemical profile of Senna plants. It emphasizes on the antioxidant and anti-infectious properties of Senna plants, which have been confirmed in preclinical studies. Further research is needed to fully utilize the phenolic compounds of Senna plants.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Integrative & Complementary Medicine

Resveratrol' biotechnological applications: Enlightening its antimicrobial and antioxidant properties

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Review Food Science & Technology

Flavonoids as potential anti-platelet aggregation agents: from biochemistry to health promoting abilities

Javad Sharifi-Rad et al.

Summary: Cardiovascular diseases are the leading cause of global mortality, with 17.9 million deaths per year. Plant extracts rich in flavonoids have gained interest for their anti-platelet and cardiovascular protective effects in treating heart-related issues. Flavonoids found in plant-based foods can prevent clot formation and alleviate the development of heart diseases.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Oncology

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

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Summary: Cancer, a leading cause of death worldwide, can be treated with surgery, chemotherapy, radiation therapy, and drug therapy. However, these treatments not only have a significant economic impact on patients but also lead to drug resistance over time. Plant-based alkaloids have shown promising potential as preventive chemotherapy options for cancer treatment. This review provides comprehensive information on various alkaloids, their medical applications, mechanisms of action, and biotechnological studies, offering valuable resources for the development of effective and affordable cancer management programs using these alkaloids.

CANCER CELL INTERNATIONAL (2022)

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Article Chemistry, Medicinal

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

Jelena Popovic-Djordjevic et al.

Summary: This article reviews the latest information on the anti-HIV activity of natural and synthetic compounds, including their history, mechanism of action, and the role of plants and their bioactive compounds as a source of new anti-HIV drugs.

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Review Integrative & Complementary Medicine

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Yasaman Taheri et al.

Summary: This review provides an overview of the medicinal use, chemical composition, pharmacological properties, and safety profile of Urtica dioica, highlighting its potential clinical value.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Oncology

In Vivo and In Vitro Protective Effects of Rosmarinic Acid against Doxorubicin-Induced Cardiotoxicity

Mahboobeh Ghasemzadeh Rahbardar et al.

Summary: The study found that rosmarinic acid provides cardioprotective effects against doxorubicin-induced toxicity, while also not affecting the anticancer effects of doxorubicin.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

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Review Cell Biology

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Prabhakar Semwal et al.

Summary: This review provides an overview of the pharmacological effects of diosgenin based on in vitro, in vivo, and clinical studies, as well as discussing the safety issues. The preclinical studies have shown promising effects on various pathologies, such as cancer, neuroprotection, atherosclerosis, asthma, and bone health. Clinical investigations have demonstrated the nontoxic nature of diosgenin and its potential benefits on cognitive function and menopause. However, further well-designed clinical trials and a better understanding of its safety profile are needed to address other potential effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Biotechnology & Applied Microbiology

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BIOMED RESEARCH INTERNATIONAL (2022)

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The roles of osteoprotegerin in cancer, far beyond a bone player

Yufei Wang et al.

Summary: Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a critical role in bone remodeling. However, it is also involved in various physiological and pathological processes, including immunoregulation, vascular function, and cancer development. Mechanistic studies have shown that OPG is associated with multiple hallmarks of cancer and may serve as a potential therapeutic target and biomarker.

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Myricetin: targeting signaling networks in cancer and its implication in chemotherapy

Zeeshan Javed et al.

Summary: Extensive research in molecular oncology has narrowed down the gaps between the complex nature of cancer and therapeutic approaches. However, therapy resistance and adverse side effects remain major challenges. Myricetin, a natural flavonoid, has gained attention due to its anti-cancer, anti-oxidant, and anti-inflammatory properties. Limited data is available regarding myricetin-based nano-delivery platforms for cancer treatment.

CANCER CELL INTERNATIONAL (2022)

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Review Oncology

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

Parina Asgharian et al.

Summary: This article discusses the anticancer properties of quercetin as a natural bioactive compound. Quercetin inhibits tumor proliferation, invasion, and metastasis by modulating multiple signaling pathways and miRNA expression. Understanding the anticancer mechanisms of quercetin can help prevent and manage various types of cancer.

CANCER CELL INTERNATIONAL (2022)

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Review Oncology

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Eunus S. Ali et al.

Summary: The MAPK pathway plays a crucial role in transmitting signals from outside the cell to inside, and is associated with cancer treatment response, normal cell pathway maintenance, and compensatory pathway activation. MAPK inhibitors often activate compensatory feedback loops, leading to resistance in tumor cells and microenvironment. Therefore, innovative combination therapies are needed to limit alternate pathway initiation.

CANCER CELL INTERNATIONAL (2022)

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Article Oncology

Clinical research in ovarian cancer: consensus recommendations from the Gynecologic Cancer InterGroup

Ignace Vergote et al.

LANCET ONCOLOGY (2022)

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Review Pharmacology & Pharmacy

Journey of Rosmarinic Acid as Biomedicine to Nano-Biomedicine for Treating Cancer: Current Strategies and Future Perspectives

Motamarri Venkata Naga Lalitha Chaitanya et al.

Summary: Rosmarinic acid is a polyphenolic metabolite found in various plants, with anticancer activity. However, its limited oral bioavailability has led to the development of nanoformulations for cancer treatment.

PHARMACEUTICS (2022)

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Article Biotechnology & Applied Microbiology

Natural Compounds or Their Derivatives against Breast Cancer: A Computational Study

Rajib Hossain et al.

Summary: The study aimed to analyze natural compounds or their derivatives as part of the development of strong inhibitors for breast cancer, and found that some compounds showed better binding affinity for BRCA1, BRCA2, and MDR1 proteins than the standard drug 5-fluorouracil.

BIOMED RESEARCH INTERNATIONAL (2022)

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Review Plant Sciences

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

Dusanka Kitic et al.

Summary: The apricot tree is a commonly known plant with medicinal properties. Its fruit is used to treat various ailments, including fever, infections, inflammation, and eye problems. Different parts of the apricot plant are used worldwide for their anticancer properties. This review provides comprehensive information on the ethnobotanical data, bioactive phytochemicals, anticancer potential, pharmacological applications, and toxicology of the apricot tree, highlighting its importance for future research.

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Article Medicine, Research & Experimental

Recent advances in the therapeutic potential of emodin for human health

Javad Sharifi-Rad et al.

Summary: Emodin is a natural bioactive compound found in certain plants. It has been used in traditional Chinese medicine for various purposes and has shown potential therapeutic applications in areas such as cancer treatment, neuroprotection, and diabetes management. However, its low bioavailability limits its clinical use.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Oncology

Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies

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Summary: Plant-based natural compounds, such as sesquiterpenoid lactones, are important chemoprotective agents for cancer prevention and research.

CANCER CELL INTERNATIONAL (2022)

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Review Oncology

Recent advances and limitations of mTOR inhibitors in the treatment of cancer

Eunus S. Ali et al.

Summary: The PI3K-Akt-mTOR signaling pathway plays a crucial role in various biological activities. Targeting mTOR with rapamycin-derived compounds has proven effective in suppressing mTOR activity and reducing cancer cell growth.

CANCER CELL INTERNATIONAL (2022)

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Review Oncology

Apoptosis evasion via long non-coding RNAs in colorectal cancer

Muhammad Irfan et al.

Summary: Long non-coding RNA (LncRNA) is a class of regulatory transcripts that are frequently dysregulated in various tumor types, including colorectal cancer (CRC). They play a role in regulating gene expression and modulating cellular activities in CRC, such as cell proliferation, invasion, metastasis, chemoresistance, and apoptosis.

CANCER CELL INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Ruhul Amin et al.

Summary: Parkinson's disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. Research has revealed that Tumor Necrosis Factor alpha has a dual role in the brain, acting as both neuroprotective and neurotoxic, with its effective pathways involving various signaling pathways.

NEUROCHEMISTRY INTERNATIONAL (2022)

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Article Multidisciplinary Sciences

Deciphering the therapeutical potentials of rosmarinic acid

Sally El Kantar et al.

Summary: Lemon balm, a herbal tea, has been used for soothing stomach cramps, indigestion, and nausea. One of its chemical constituents, rosmarinic acid (RA), has shown therapeutic potentials against cancer, inflammatory diseases, and neuronal diseases such as Alzheimer's disease (AD). This study successfully extracted and purified RA, determined its structure using nuclear magnetic resonance (NMR) spectroscopy, and investigated its anti-aggregation inhibition potentials, anti-cancer effects, and electrochemical properties. The data demonstrates that RA is a biologically active natural product with therapeutic potentials for drug discovery in AD, cancer therapy, and inflammatory diseases.

SCIENTIFIC REPORTS (2022)

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Review Integrative & Complementary Medicine

Eryngium caeruleum: an update on ethnobotany, phytochemistry and biomedical applications

Dmitryi Alexeevich Konovalov et al.

Summary: This article provides a comprehensive review on Eryngium caeruleum, including its botanical, ethnopharmacological, phytochemical, pharmacological mechanisms, and nutritional properties. Experimental studies have shown that Eryngium caeruleum has multiple beneficial effects on human health and effectively relieves dysmenorrhea. However, further translational and human clinical studies are needed to establish effective therapeutic doses in humans.

CHINESE MEDICINE (2022)

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Review Cell Biology

Recent updates on anticancer mechanisms of polyphenols

Eshita Sharma et al.

Summary: This article discusses the importance of anticancer herbal compounds in cancer treatment, particularly polyphenols. Polyphenols have been proven to effectively inhibit tumor growth with fewer side effects and can enhance the sensitivity of cells to other therapies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer

Jiachao Zhao et al.

Summary: This review summarizes the recent research on the use of rosmarinic acid (RA)-enriched dietary supplements in cancer prevention and treatment. RA is known for its excellent antioxidant properties and exhibits anticancer activity by regulating multiple biological processes. These findings suggest that daily use of RA supplements can be beneficial for preventing and treating tumors.

BIOMOLECULES (2022)

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Review Health Care Sciences & Services

Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Javad Sharifi-Rad et al.

Summary: This review provides a comprehensive overview of the latest developments in AD treatment through the administration of phytochemicals. The results of the studies demonstrate that bioactive compounds from plants have the ability to prevent and stop the progression of Alzheimer's.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Oncology

Natural essential oils as a new therapeutic tool in colorectal cancer

Stefania Garzoli et al.

Summary: This paper reviews the preclinical studies on the role and mechanisms of essential oils in colorectal cancer (CRC). The results showed that essential oils exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. Therefore, essential oils can be considered as efficient complementary therapies in chemotherapy in CRC.

CANCER CELL INTERNATIONAL (2022)

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Review Multidisciplinary Sciences

Prospective Asian plants with corroborated antiviral potentials: Position standing in recent years

Sania Ashrafi et al.

Summary: Viral diseases caused by viruses are widespread and have posed significant challenges to human existence. Traditional medicinal plants have been used for the treatment of infectious diseases, while modern drug discovery techniques offer potential antiviral compounds.

BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Molecular Basis of the Antiangiogenic Action of Rosmarinic Acid, a Natural Compound Targeting Fibroblast Growth Factor-2/FGFR Interactions

Katiuscia Pagano et al.

Summary: This study discusses the ability of rosmarinic acid (RA) to induce the dissociation of the FGF2/FGFR complex, showing that RA competes with FGF2 for binding to FGFR-D2 domain and destabilizes the complex. Cellular studies confirmed that RA inhibits FGF2-induced endothelial cell proliferation and FGFR activation, suggesting the potential for developing new extracellular inhibitors targeting the FGF/FGFR pathways based on these findings.

CHEMBIOCHEM (2021)

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Review Nutrition & Dietetics

Therapeutic Potential of Neoechinulins and Their Derivatives: An Overview of the Molecular Mechanisms Behind Pharmacological Activities

Javad Sharifi-Rad et al.

Summary: Neoechinulins are a type of indole alkaloids with various biological activities, isolated from both fungal and non-fungal sources. The aim of this research is to lay the foundation for the discovery of new neoechinulin-based drugs in the future, requiring further toxicological and clinical studies.

FRONTIERS IN NUTRITION (2021)

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Review Chemistry, Medicinal

Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective

Bahare Salehi et al.

Summary: The Ficus genus, typically tropical plants, has been widely used in traditional medicine for treating a variety of diseases and contain rich secondary metabolites with diverse applications.

PHYTOTHERAPY RESEARCH (2021)

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Article Chemistry, Applied

Molecularly imprinted polymers for selective extraction of rosmarinic acid from Rosmarinus officinalis L.

Engy M. Saad et al.

Summary: This study demonstrates a robust and reproducible approach for selectively extracting rosmarinic acid using molecularly imprinted polymers. By optimizing the molecularly imprinted solid phase extraction protocol, a remarkably selective extraction of RA from real-world Rosmarinus officinalis L. extract was achieved, with a recovery rate and purity of 81.96 +/- 6.33% and 80.59 +/- 0.30%, respectively.

FOOD CHEMISTRY (2021)

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Article Chemistry, Applied

Comparison between synthetic and rosemary-based antioxidants for the deep frying of French fries in refined soybean oils evaluated by chemical and non-destructive rapid methods

Pengjuan Li et al.

Summary: The study found that using rosemary-based antioxidants is more effective than synthetic antioxidants in frying food, with rosmarinic acid being the most effective. LF-NMR and NIRS methods can rapidly and efficiently monitor changes in the frying process.

FOOD CHEMISTRY (2021)

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Article Medicine, Research & Experimental

Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 ΚB-p53-caspase-3 pathways modulation

Marwa A. Mahmoud et al.

Summary: Rosmarinic acid, a natural polyphenolic compound, showed chemo-preventive and therapeutic potential in breast cancer mice. It suppressed NF-KB, TNF-α, VEGF levels, and activated apoptosis markers. It also synergistically enhanced the antitumor efficacy of Paclitaxel by targeting multiple breast cancer-related signaling pathways.

JOURNAL OF APPLIED BIOMEDICINE (2021)

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Article Medicine, Research & Experimental

Rosmarinic acid inhibits cell proliferation, migration, and invasion and induces apoptosis in human glioma cells

Yunsheng Liu et al.

Summary: The study found that RA, as a Fyn inhibitor, has anti-tumor effects in U251 and U343 glioma cells, significantly suppressing cell proliferation, migration, and invasion, and inducing apoptosis. Additionally, RA exerts its cytotoxicity by modulating the PI3K/Akt/NF-kappa B signaling pathway.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Cell Biology

Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy

Javad Sharifi-Rad et al.

Summary: Paclitaxel, derived from the bark of the yew tree, is a broad-spectrum anticancer compound used in the treatment of various cancers. Limited solubility and toxicity issues have led to the exploration of nanotechnology and nanoparticles for increased drug half-life, reduced toxicity, and targeted delivery.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Medicine, General & Internal

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

Dimitris Tsoukalas et al.

Summary: This study evaluated the beneficial effect of a novel nutraceutical formulation on motor activity and anxiety in old rats. The supplement improved locomotor activity in a dose-dependent manner and decreased anxiety behaviors significantly. These findings provide insights for clinical use in elderly individuals to enhance physical strength and improve quality of life.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Thinking Outside the Ischemia Box: Advancements in the Use of Multiple Sclerosis Drugs in Ischemic Stroke

Athina-Maria Aloizou et al.

Summary: Numerous studies have explored the potential of using multiple sclerosis disease-modifying drugs in the setting of ischemic stroke, yielding mostly positive results in animal studies. However, concerns on safety and other issues need to be addressed before implementing these drugs in clinical practice.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

Divya Jain et al.

Summary: Smoking produces over 4000 chemicals that harm every part of the human body, with specific severe effects on the liver. It leads to cytotoxic substances, chronic liver injury, and increases the risk of liver cancer, while also impacting immune responses and interfering with hepatitis C therapy responses. Efforts to reduce smoking prevalence aim to improve public health and reduce premature death.

JOURNAL OF ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Curcumin and Carnosic Acid Cooperate to Inhibit Proliferation and Alter Mitochondrial Function of Metastatic Prostate Cancer Cells

Saniya Ossikbayeva et al.

Summary: Plant polyphenols exhibit anticancer activity, and the combination of curcumin and carnosic acid at non-cytotoxic concentrations can effectively induce massive apoptosis in certain cancer cells. This synergistic effect was also observed in metastatic prostate cancer cell cultures, where the treatment inhibited cell proliferation and induced cell cycle arrest without generating oxidative stress. These findings suggest that the combination of curcumin and carnosic acid may be a promising anticancer modality targeting different cancer cells through distinct mechanisms.

ANTIOXIDANTS (2021)

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Review Pharmacology & Pharmacy

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

Javad Sharifi-Rad et al.

Summary: Plants of the genus Cinnamomum have diverse medicinal values, with bioactive compounds showing various pharmacological activities such as antibacterial, anti-inflammatory, and antioxidant effects. Clinical studies and toxicological data further support the pharmacological importance of Cinnamomum plants.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Reversal of brain aging by targeting telomerase: A nutraceutical approach

Dimitris Tsoukalas et al.

Summary: The study found that the 'Reverse(TM)' supplement can promote telomerase activity and TERT expression in the brains of middle-aged rats, which may contribute to alleviating central nervous system diseases.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy

Javad Sharifi-Rad et al.

Summary: This systematic review analyzed the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. The study found that certain compounds may have anticonvulsant mechanisms similar to new generation antiepileptic drugs, opening up new perspectives for the development of natural anticonvulsant drugs.

NEUROCHEMICAL RESEARCH (2021)

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Review Cell Biology

Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms

Javad Sharifi-Rad et al.

Summary: Coumarins, belonging to the benzopyrone family, are commonly found in medicinal plants and have a wide range of pharmacological activities. Despite the lack of studies on their bioavailability, further investigations are needed to explore the bioavailability and therapeutic modes of different coumarins. With their synthetic accessibility and abundance in medicinal plants, coumarins show promise as therapeutic agents in various medical fields.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Cell Biology

Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits

Javad Sharifi-Rad et al.

Summary: Genistein, an isoflavone found in plants, exhibits various biological activities such as antioxidant, anti-inflammatory, antibacterial, and antiviral effects. It is known to protect against cardiovascular diseases and reduce the incidence of certain cancers, especially breast cancer, by displacing estrogen from cellular receptors and blocking hormonal activity. Further research is needed to explore the efficacy, safety, and potential of nanotechnologies to enhance bioavailability and therapeutic efficacy of genistein.

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Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways

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Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model

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Effect of methyl jasmonate on phenolic acids accumulation and the expression profile of their biosynthesis-related genes in Mentha spicata hairy root cultures

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SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza

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Comparison between Pressurized Liquid Extraction and Conventional Soxhlet Extraction for Rosemary Antioxidants, Yield, Composition, and Environmental Footprint

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Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells

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The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation-Evidence from In Vivo Studies

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Phosphodiesterase-5 inhibitors ameliorate structural kidney damage in a rat model of contrast-induced nephropathy

Andrei Mihai Iordache et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Article Cell Biology

The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms

Yalan Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Nutrition & Dietetics

Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats

Maria Zych et al.

NUTRIENTS (2019)

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Review Biochemistry & Molecular Biology

Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential

Bahare Salehi et al.

MOLECULES (2019)

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Article Medicine, Research & Experimental

Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway

Li Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

Epibatidine: A Promising Natural Alkaloid in Health

Bahare Salehi et al.

BIOMOLECULES (2019)

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Article Biochemistry & Molecular Biology

Regulation effects of rosemary (Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD rats

Si-Jian Wang et al.

FOOD & FUNCTION (2019)

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Review Biotechnology & Applied Microbiology

Anticancer potential of rosmarinic acid and its improved production through biotechnological interventions and functional genomics

Mallappa Kumara Swamy et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Black rice anthocyanin-rich extract and rosmarinic acid, alone and in combination, protect against DSS-induced colitis in mice

Lei Zhao et al.

FOOD & FUNCTION (2018)

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Article Pharmacology & Pharmacy

Rosmarinic Acid Activates AMPK to Inhibit Metastasis of Colorectal Cancer

Yo-Han Han et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury

Jianbin Min et al.

MOLECULES (2018)

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Article Oncology

Notch1 promotes vasculogenic mimicry in hepatocellular carcinoma by inducing EMT signaling

Chen Jue et al.

ONCOTARGET (2017)

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Article Food Science & Technology

Oil distillation wastewaters from aromatic herbs as new natural source of antioxidant compounds

Rita Celano et al.

FOOD RESEARCH INTERNATIONAL (2017)

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Article Oncology

Staphylococcus aureus colonisation in patients from a primary regional hospital

Anca Ungureanu et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Medicine, Research & Experimental

Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline

Ramona Cioboata et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

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Review Pharmacology & Pharmacy

A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective

Valery V. Wojciechowski et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Medicine, Research & Experimental

Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant

Alina Tanase et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

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Article Food Science & Technology

Study of the interactions between rosmarinic acid and bovine milk whey protein α-Lactalbumin, β-Lactoglobulin and Lactoferrin

Vincenza Ferraro et al.

FOOD RESEARCH INTERNATIONAL (2015)

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Article Biotechnology & Applied Microbiology

Potential of Different Coleus blumei Tissues for Rosmarinic Acid Production

Natasa Bauer et al.

FOOD TECHNOLOGY AND BIOTECHNOLOGY (2015)

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Article Food Science & Technology

Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation

Ji-Won Lee et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2015)

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Article Pharmacology & Pharmacy

Anti-inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation

Joao Rocha et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2015)

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Article Plant Sciences

Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity

Li Tao et al.

PHYTOMEDICINE (2014)

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Article Pathology

The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis

Karthikkumar Venkatachalam et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2013)

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Article Chemistry, Applied

Cytotoxic impact of phenolics from Lamiaceae species on human breast cancer cells

Izabela Berdowska et al.

FOOD CHEMISTRY (2013)

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Article Agricultural Engineering

Protective effects of Lavandula viridis L'Her extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line

Patricia Costa et al.

INDUSTRIAL CROPS AND PRODUCTS (2013)

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Review Oncology

Ocimum Sanctum L (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer

Manjeshwar Shrinath Baliga et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2013)

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Review Plant Sciences

Rosmarinic acid: new aspects

Maike Petersen

PHYTOCHEMISTRY REVIEWS (2013)

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Review Biotechnology & Applied Microbiology

Rosmarinic acid and its derivatives: biotechnology and applications

Victor P. Bulgakov et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2012)

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Article Integrative & Complementary Medicine

Towards Modernization of the Formulation of the Traditional Uighur Medicine Herbal Preparation Abnormal Savda Munziq

Murat Kizaibek et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

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Article Food Science & Technology

Dietary intake of rosmarinic acid by ApcMin mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development

Ankur Karmokar et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2012)

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Article Plant Sciences

Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro

Joseph Tai et al.

PHYTOMEDICINE (2012)

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Article Chemistry, Medicinal

Comparative study of rosmarinic acid content in some plants of Labiatae family

Maryam Shekarchi et al.

PHARMACOGNOSY MAGAZINE (2012)

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Article Biochemistry & Molecular Biology

The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ

Ophelie Fadel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)

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Article Geriatrics & Gerontology

Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans

Kerstin Pietsch et al.

BIOGERONTOLOGY (2011)

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Article Food Science & Technology

Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells

An-Chin Cheng et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

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Article Toxicology

Antitumor Initiating Potential of Rosmarinic Acid in 7,12-Dimethylbenz(a)anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Chezhiyan Anusuya et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2011)

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Article Plant Sciences

Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line

Manuel Alejandro Encalada et al.

PLANT FOODS FOR HUMAN NUTRITION (2011)

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Article Plant Sciences

Substrate promiscuity of a rosmarinic acid synthase from lavender (Lavandula angustifolia L.)

Christian Landmann et al.

PLANTA (2011)

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Article Biochemical Research Methods

Structure and substrate docking of a hydroxy(phenyl)pyruvate reductase from the higher plant Coleus blumei Benth.

Verena Janiak et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

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Review Biotechnology & Applied Microbiology

Bench to batch: advances in plant cell culture for producing useful products

Pamela J. Weathers et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)

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Article Dermatology

Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes

Jitka Vostalova et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2010)

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Article Oncology

Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells

Dong-Oh Moon et al.

CANCER LETTERS (2010)

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Article Chemistry, Medicinal

Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances

Dong Hyun Park et al.

FITOTERAPIA (2010)

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Article Agriculture, Multidisciplinary

Effects of Chitosan and Rosmarinate Esters on the Physical and Oxidative Stability of Liposomes

Atikorn Panya et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

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Article Biochemistry & Molecular Biology

Anti-Invasion Effect of Rosmarinic Acid via the Extracellular Signal-Regulated Kinase and Oxidation-Reduction Pathway in Ls174-T Cells

Yichun Xu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

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Article Plant Sciences

In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis

Gui-Sheng Li et al.

PHYTOMEDICINE (2010)

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Article Plant Sciences

Inhibition of Bone Metastasis from Breast Carcinoma by Rosmarinic Acid

Yichun Xu et al.

PLANTA MEDICA (2010)

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Article Toxicology

The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells

Jaroslaw Paluszczak et al.

TOXICOLOGY LETTERS (2010)

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Article Pathology

Phenolic Compounds Prevent Alzheimer's Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Tsuyoshi Hamaguchi et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

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Article Pharmacology & Pharmacy

Preventive Effects of Salvianolic Acid B on Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition of Human Kidney Cells

Gang Ya et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)

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Article Oncology

Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways

Yubin Hao et al.

INTERNATIONAL JOURNAL OF CANCER (2009)

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Article Oncology

Salvia Fruticosa, Salvia Officinalis, and Rosmarinic Acid Induce Apoptosis and Inhibit Proliferation of Human Colorectal Cell Lines: The Role in MAPK/ERK Pathway

Cristina P. R. Xavier et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)

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Review Biochemistry & Molecular Biology

Evolution of rosmarinic acid biosynthesis

Maike Petersen et al.

PHYTOCHEMISTRY (2009)

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Article Pharmacology & Pharmacy

Inhibitory effects of salvianolic acid B on the high glucose-induced mesangial proliferation via NF-κB-dependent pathway

Pei Luo et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)

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Article Pharmacology & Pharmacy

Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats

Eun Seok Kang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Article Nutrition & Dietetics

Rosmarinic Acid Antagonizes Activator Protein-1-Dependent Activation of Cyclooxygenase-2 Expression in Human Cancer and Nonmalignant Cell Lines

Kristen A. Scheckel et al.

JOURNAL OF NUTRITION (2008)

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Article Multidisciplinary Sciences

Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling

Chen-Li Liu et al.

PLOS ONE (2007)

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Article Biochemistry & Molecular Biology

High rabdosiin and rosmarinic acid production in Eritrichium sericeum callus cultures and the effect of the calli on masugi-nephritis in rats

Yuliya V. Inyushkina et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2007)

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Article Pharmacology & Pharmacy

Comparison of rosmarinic acid content in commercial tinctures produced from fresh and dried lemon balm (Melissa officinalis)

Alberto Sanchez-Medina et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2007)

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Article Immunology

Rosmarinic acid induces apoptosis of activated t cells from rheumatoid arthritis patients via mitochondrial pathway

Yun-Gyoung Hur et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2007)

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Article Plant Sciences

Caffeic acid metabolites from Eritrichium sericeum cell cultures

SA Fedoreyev et al.

PLANTA MEDICA (2005)

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Review Biochemistry & Molecular Biology

Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza

RW Jiang et al.

CURRENT MEDICINAL CHEMISTRY (2005)

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Article Oncology

Rosmarinic acid inhibits epidermal inflammatory responses:: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model

N Osakabe et al.

CARCINOGENESIS (2004)

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Article Chemistry, Medicinal

HIV-1 integrase inhibitory substances from Coleus parvifolius

S Tewtrakul et al.

PHYTOTHERAPY RESEARCH (2003)

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Article Biochemistry & Molecular Biology

Molecules of interest - Rosmarinic acid

M Petersen et al.

PHYTOCHEMISTRY (2003)

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Article Urology & Nephrology

Suppressive effects of Rosmarinic acid on mesangioproliferative glomerulonephritis in rats

T Makina et al.

NEPHRON (2002)

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Article Pharmacology & Pharmacy

Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza

IS Abd-Elazem et al.

ANTIVIRAL RESEARCH (2002)

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Article Plant Sciences

Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents

T Makino et al.

PLANTA MEDICA (2001)

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