An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases

Article Chemistry, Multidisciplinary

Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease

An-Qi Dong et al.

Summary: This study demonstrates the anti-neuroinflammatory activity of PPX through enhancing autophagy activity in astrocytes, which provides a new mechanism for the beneficial effect of PPX in Parkinson's disease therapy.

ACTA PHARMACOLOGICA SINICA (2023)

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Article Biochemistry & Molecular Biology

MST1 mediates the N-methyl-d-aspartate-induced excitotoxicity in mouse cortical neurons

Jane Melissa Lim et al.

Summary: This study demonstrates that excessive activation of NMDA receptor leads to excitotoxic neuronal death by increasing calcium influx. The cleavage and activation of MST1 by calpain 1, mediated by NMDA, promotes excitotoxicity in mouse cortical neurons.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Review Medicine, Research & Experimental

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Richard Cunningham et al.

Summary: This article discusses the importance of the Hippo signaling pathway in cancer research and explores recent discoveries on how this pathway influences cancer progression. It also focuses on the latest efforts to target the key effectors of the pathway for therapeutic purposes in both preclinical and clinical settings.

CLINICAL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease

Pik-Shan Lo et al.

Summary: This study found that the expression of DCC is essential for the survival of mDA neurons in adult and aging mice, and could be relevant to the degenerative processes in Parkinson's disease (PD).

JOURNAL OF NEUROCHEMISTRY (2022)

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Review Cell & Tissue Engineering

Hippo-Yap/Taz signalling in zebrafish regeneration

Susanna E. Riley et al.

Summary: Tissue regeneration capacity varies between mammals and lower vertebrates, with zebrafish showing robust regeneration abilities associated with the Hippo pathway. The effectors Yap/Taz of the Hippo pathway play a role in zebrafish regeneration, with potential therapeutic implications for enhancing regeneration in mammals.

NPJ REGENERATIVE MEDICINE (2022)

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Article Cell Biology

YAP: a novel target for Alzheimer's disease

Xingxing Xu et al.

Aging-US (2022)

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Article Neurosciences

Tat-SynGAP improves angiogenesis and post-stroke recovery by inhibiting MST1/JNK signaling

Hui Yang et al.

Summary: This study demonstrates that Tat-SynGAP (670-685aa) reduces neuronal apoptosis and cerebral infarction volume by inhibiting MST1/JNK signaling pathway, while maintaining vascular stability and blood-brain barrier integrity.

BRAIN RESEARCH BULLETIN (2022)

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Article Cell Biology

MiR-135a-5p and Mst1 regulate MPP +-1 induced apoptosis and autophagy in Parkinson?s disease model in vitro

Yinying Qin et al.

Summary: This study reveals the important role of Mst1 in regulating neuronal cell death in Parkinson's disease models, and suggests that the miR-135a-5p/Mst1 axis could be a potential therapeutic target for PD treatment.

CELLULAR SIGNALLING (2022)

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Article Neurosciences

Relationship Between Plasma Lipopolysaccharides, Gut Microbiota, and Dementia: A Cross-Sectional Study

Naoki Saji et al.

Summary: This study found associations between plasma lipopolysaccharide (LPS) concentration and cognitive decline, as well as cerebral small vessel disease (SVD). Plasma LPS concentration was also correlated with beneficial gut microbial metabolites. This suggests that plasma LPS may be a risk factor for cognitive decline.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Neurosciences

Effect of TDP43-CTFs35 on Brain Endothelial Cell Functions in Cerebral Ischemic Injury

Xiaotian Xu et al.

Summary: Pathological changes in the brain endothelium play a crucial role in the progression of ischemic stroke. This study showed that TDP43-CTFs35 inhibits the activity of the Hippo signaling pathway, leading to impaired brain endothelial cell migration and tight junction protein expression. These findings provide new insights into the regulation of brain vascular endothelial cells.

MOLECULAR NEUROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Positive Effect of α-Asaronol on the Incidence of Post-Stroke Epilepsy for Rat with Cerebral Ischemia-Reperfusion Injury

Lan Jiang et al.

Summary: This study confirmed that the co-administration of alpha-asaronol and n-butylphthalide has a further improvement on neurological function and reduction of brain infarct volume for rats with cerebral ischemia-reperfusion injury. It also found that alpha-asaronol could decrease the incidence of post-stroke epilepsy compared to n-butylphthalide alone. Overall, this research provides valuable data for the follow-up prodrug research of alpha-asaronol and n-butylphthalide.

MOLECULES (2022)

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Article Multidisciplinary Sciences

STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy

Jared T. Hinkle et al.

Summary: This study reveals that pathological alpha Syn aggregates in idiopathic Parkinson's disease can cause STING-dependent neuroinflammation and dopaminergic neurodegeneration. Microglial STING activation plays a crucial role in the development of alpha-synudeinopathies, including Parkinson's disease.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Geriatrics & Gerontology

Neurons Release Injured Mitochondria as Help-Me Signaling After Ischemic Stroke

Li Gao et al.

Summary: Mitochondrial dysfunction is a major cause of neuronal death after stroke, and intercellular mitochondrial transfer shows promise as a potential therapeutic approach. Neurons release more mitochondria when exposed to challenges like acidosis, hydrogen peroxide, NMDA, or glutamate, which are then engulfed by adjacent astrocytes. This transfer may serve as a signaling mechanism to mediate the interaction between neurons and astrocytes.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Physiology

Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke

Christian J. Hoffmann et al.

Summary: This study demonstrated the differential control of paracrine and endocrine Igf1 and Igfbp3 by Zfp580 after stroke, suggesting that inhibition of Zfp580 might be a new treatment target leading to increased activity of Igf1 to improve stroke outcome.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Medicine, General & Internal

The Assessment of Endovascular Therapies in Ischemic Stroke: Management, Problems and Future Approaches

Tadeusz J. Popiela et al.

Summary: Ischemic stroke is a major global cause of mortality, with treatment options including intravenous rt-PA and mechanical thrombectomy. However, improvements in diagnostic tools and reducing treatment time are necessary to enhance patient outcomes, as well as further research into the cellular mechanisms and mitochondrial effects of reperfusion.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Neurosciences

Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein

Stephanie Lohmann et al.

Summary: This study investigates the long-term effects of ischemic stroke on the pathogenesis of Parkinson's disease. The results show that ischemia-induced neuronal loss and inflammation increase again 360 days post surgery, accompanied by an increase in alpha-synuclein aggregation and late loss of dopaminergic neurons in the substantia nigra.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

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Article Neurosciences

Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis

Yingzhen Zhang et al.

Summary: This study investigated the role of endothelin-1 (ET-1) in amyotrophic lateral sclerosis (ALS) and its effect on motor neurons. The researchers found that the expression of ET-1 was up-regulated in the spinal cord of ALS mice, primarily in astrocytes, while the expression of ET-A and ET-B receptors decreased. ET-1 was found to have a toxic effect on motor neurons, which could be rescued by selective receptor antagonists. Proteomic analysis revealed differential expression of multiple proteins after ET-1 treatment in ALS cell models. These findings suggest that targeting ET-1 could be a potential therapeutic strategy for ALS.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Neurosciences

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

Emma Gerrits et al.

Summary: In this study, blood-brain barrier dysfunction and severely affected neurovasculature were demonstrated in FTD-GRN. Disease-associated subtypes of astrocytes and endothelial cells were identified in FTD-GRN. The study suggests that the neurovascular unit is severely affected in FTD-GRN.

NATURE NEUROSCIENCE (2022)

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Article Clinical Neurology

Pathological substrate of memory impairment in multiple system atrophy

Yasuo Miki et al.

Summary: This study investigated how abnormal alpha-synuclein in the hippocampus leads to memory impairment in multiple system atrophy (MSA). The results suggest that increased alpha-synuclein oligomers may be a pathological cause of memory impairment in MSA.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2022)

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Article Neurosciences

MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease

Hui Wang et al.

Summary: This study suggests that MST1 is involved in the occurrence and development of AD. Overexpression of MST1 induces AD-like phenotype and accelerates cognitive decline and neuronal apoptosis in 5xFAD mice. MST1 promotes neuronal apoptosis by interacting with p53.

PROGRESS IN NEUROBIOLOGY (2022)

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Review Medicine, General & Internal

Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis

Yangni Li et al.

Summary: This study assessed the association between IGF-1 and the risk and outcome of ischemic stroke. The meta-analysis results showed that higher serum levels of IGF-1 were significantly correlated with a lower risk of ischemic stroke and better outcome.

BMJ OPEN (2022)

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Review Geriatrics & Gerontology

Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease

Mengyuan Guo et al.

Summary: This review discusses the pathogenesis of Parkinson's disease (PD) and the potential role of hypoxia in its development. By describing the risk factors for PD and the influence of hypoxia on these factors, we emphasize the critical role of hypoxia in the pathogenesis of PD. Our study provides new insights for exploring the pathogenesis and therapeutic targets of PD.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Pharmacology & Pharmacy

Endothelial Antibody Factory at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases

Reynald Thinard et al.

Summary: This study developed a novel approach to facilitate the penetration of antibody fragments into the brain parenchyma by leveraging the homing properties of endothelial progenitor cells. The results showed that the production and secretion of antibody fragments at the blood-brain barrier level could lead to their migration to the brain parenchyma where they might exert a therapeutic effect.

PHARMACEUTICS (2022)

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Article Cell Biology

Vascular Endothelial Growth Factor Receptor-1 Modulates Hypoxia-Mediated Endothelial Senescence and Cellular Membrane Stiffness via YAP-1 Pathways

Ramcharan Singh Angom et al.

Summary: Hypoxia leads to senescence in endothelial cells (ECs), with VEGFR-1 and YAP-1 playing important roles in this process. Senescent ECs exhibit unique morphological and nanomechanical signatures.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Pharmacology & Pharmacy

Hallmarks of neurodegenerative disease: A systems pharmacology perspective

Peter Bloomingdale et al.

Summary: Neurodegenerative diseases are a significant public health concern with complex etiology, hindered by drug development failures. Quantitative systems pharmacology models could aid in understanding pharmacological strategies and reducing drug attrition rates.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2022)

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Review Cell Biology

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies

Joseph Phan et al.

Summary: Stroke is the most common cause of epilepsy, which can lead to poststroke epilepsy. The diagnosis is usually made using imaging modalities, blood biomarkers, and electroencephalography.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Environmental Sciences

Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons

Zhuo-Fan Liu et al.

Summary: Excessive manganese exposure can lead to manganese toxicity, which can be alleviated by melatonin through regulating the Mst1-JNK signaling pathway, reducing manganese-induced mitochondrial fragmentation, and maintaining mitochondrial network.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Geriatrics & Gerontology

Ischemia as a common trigger for Alzheimer's disease

Karin Elman-Shina et al.

Summary: Alzheimer's disease is characterized by the accumulation of beta-amyloid derivatives and cognitive decline. Vascular-related pathology is one of the common etiologies, and brain ischemia plays a role in the development of AD. Hyperbaric oxygen therapy has shown potential in reversing brain ischemia and improving brain function.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Cell Biology

Willin/FRMD6 Mediates Mitochondrial Dysfunction Relevant to Neuronal Aβ Toxicity

Doris Chen et al.

Summary: This study identifies Willin/FRMD6 as a potential risk gene for Alzheimer's disease (AD), and demonstrates the direct effects of A beta on its expression. The study also reveals mitochondrial oxidative stress as a novel mechanism underlying the role of Willin/FRMD6 in AD pathogenesis. Additionally, the study shows that knockdown of Willin/FRMD6 leads to mitochondrial dysfunction and upregulation of ERK1/2 signaling, which are key early features of AD. Increasing Willin/FRMD6 expression may serve as a therapeutic strategy for protecting against A beta-induced mitochondrial and neuronal dysfunction.

CELLS (2022)

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Review Clinical Neurology

Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases

Juanmei Gao et al.

Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating the balance of neural stem/progenitor cells (NSCs) proliferation and differentiation, which is essential for the development and maintenance of the nervous system. Recent findings suggest that components of the Wnt/beta-catenin signaling pathway are involved in the regulation of functional brain circuits, providing potential therapeutic targets for neurological diseases.

NEUROSCIENTIST (2021)

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Review Biology

Hypoxia Signaling in Parkinson's Disease: There Is Use in Asking What HIF?

Laura Leston Pinilla et al.

Summary: Parkinson's disease is a neurodegenerative disorder associated with reductions in oxygen supply to neurons. Hypoxia-induced cellular changes can exacerbate neurodegeneration, highlighting the potential role of HIF-1 alpha in regulating these processes. Modulating HIF-1 alpha signaling presents a promising novel therapeutic approach for Parkinson's disease.

BIOLOGY-BASEL (2021)

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Review Cell Biology

Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies

Tao Song et al.

Summary: Evidence suggests that metabolic changes in the brain associated with neuroinflammation, oxidative stress, and mitochondrial dysfunction play a key role in the pathophysiology of MCI and AD. Studies showed decreased levels of N-acetyl aspartate and creatine, increased myo-inositol, decreased glutathione, and disrupted energy metabolism. The hippocampus displayed the most significant alterations in these metabolites.

AGEING RESEARCH REVIEWS (2021)

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Article Oncology

Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis

Pei Li et al.

Summary: Linc00887 inhibits the progression of cervical cancer by sponging miR-454-3p and activating the FRMD6-Hippo signaling pathway, as confirmed through in vitro and in vivo experiments.

CANCER CELL INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

A beneficial role for elevated extracellular glutamate in Amyotrophic Lateral Sclerosis and cerebral ischemia

Kathryn A. Schiel

Summary: The hypothesis suggests that increased extracellular glutamate in ALS and cerebral ischemia might be beneficial by stimulating glutamate utilization as metabolic fuel. The role of extracellular glutamate in ischemia is debated, with its potential for excitotoxicity in early in vitro studies in contrast to its oxidation in later in vivo studies. The activity of NMDA glutamate receptors may determine whether extracellular glutamate is detrimental or beneficial.

BIOESSAYS (2021)

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Article Neurosciences

The neuroprotective effects of Insulin-Like Growth Factor 1 via the Hippo/YAP signaling pathway are mediated by the PI3K/AKT cascade following cerebral ischemia/reperfusion injury

Pian Gong et al.

Summary: The study demonstrates that IGF-1 exerts neuroprotective effects following ischemic stroke by activating the Hippo/YAP signaling pathway, leading to improved cell viability in vitro and reduced neurological deficits, brain edema, neuronal death and apoptosis, and cerebral infarct volume in vivo.

BRAIN RESEARCH BULLETIN (2021)

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Review Developmental Biology

Neuronal Hippo signaling: From development to diseases

Manas Ranjan Sahu et al.

Summary: The Hippo signaling pathway plays crucial roles in various stages of neuronal development, including proliferation, migration, differentiation, and apoptosis. Overactivation of the pathway may lead to neurodegenerative diseases, but it could also be targeted for therapeutic purposes. Recent studies have highlighted the regenerative potential of this pathway in neuronal repair.

DEVELOPMENTAL NEUROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features

Melissa Jasmin et al.

Summary: The netrin-1/DCC ligand/receptor pair plays key roles in CNS development, and although they are expressed in the adult brain, their function in mature neurons is not well understood. Research shows that netrin-1 plays a critical role in the fate of adult dopamine neurons, and targeting netrin-1 signaling may have therapeutic potential in Parkinson's disease. Studies in animal models suggest that overexpression of netrin-1 or administration of recombinant netrin-1 can be neuroprotective and neurorestorative in PD.

EMBO JOURNAL (2021)

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Article Neurosciences

Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old

Thomas G. Beach et al.

Summary: The study found that comorbid neurodegenerative and cerebrovascular diseases are common in Alzheimer's disease dementia (ADD) patients, not only in the elderly but also in early-onset ADD patients. As age increases, the prevalence of certain comorbidities also increases.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Article Cell Biology

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

Xianmei Pan et al.

Summary: The study reveals the significant role of YAP in vascular senescence, with inhibition or overexpression of YAP affecting the aging process in both cells and vascular tissues. Furthermore, YAP-induced senescence is associated with mTOR pathway activation and autophagic flux blockage, which can be relieved by YAP inhibition.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease

Ryszard Pluta et al.

Summary: Recent evidence suggests that amyloid and tau protein play vital roles in post-ischemic neurodegeneration of CA1 pyramidal neurons in the hippocampus. Studies have revealed dysregulation of Alzheimer's disease-related genes in hippocampus neurodegeneration after ischemia, indicating similarities to Alzheimer's disease in gene expression. Understanding the interplay between Alzheimer's disease-associated proteins and genes in post-ischemic neurodegeneration of the hippocampus is crucial for therapeutic development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Changes in Smad1/5/9 expression and phosphorylation in astrocytes of the rat hippocampus after transient global cerebral ischemia

Takayuki Nakajima et al.

Summary: This study investigated the expression and phosphorylation of Smad1/5/9 in the hippocampus after global cerebral ischemia in rats, finding that activins and bone morphogenetic proteins may be involved in the phosphorylation of Smad1/5/9 after ischemia. Additionally, transforming growth factor-β1 was identified as a key molecule for ischemia-induced Smad1/5/9 phosphorylation in astrocytes.

JOURNAL OF CHEMICAL NEUROANATOMY (2021)

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Review Geriatrics & Gerontology

Brain Ischemia as a Prelude to Alzheimer's Disease

Ryszard Pluta et al.

Summary: Transient ischemic brain injury results in massive neuronal death in the hippocampus and progressive atrophy of brain structures. Post-ischemic brain neurodegeneration can continue well beyond the acute stage and is associated with the deposition of folding proteins like amyloid and tau protein. Studies have shown dysregulation of Alzheimer's disease-associated genes in the development of post-ischemic brain neurodegeneration, suggesting a common pathway with Alzheimer's disease.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Review Nutrition & Dietetics

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

Clayton Vasey et al.

Summary: Melatonin plays a crucial role in regulating sleep and circadian rhythms, with dysregulation potentially leading to various disorders. However, there is still a lack of extensive clinical research on the therapeutic use of melatonin in the past 5 years.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

YAP and TAZ Mediators at the Crossroad between Metabolic and Cellular Reprogramming

Giorgia Di Benedetto et al.

Summary: Cellular reprogramming involves converting specialized cells into another type or inducing pluripotent stem cells, requiring modifications in the epigenetic asset and gene regulatory networks. The process involves a metabolic rearrangement similar to tumorigenesis and relies on a network of signaling pathways with a crucial role played by components of the Hippo pathway, YAP and TAZ.

METABOLITES (2021)

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Article Genetics & Heredity

Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism

Maya Chopra et al.

Summary: Loss of ANKRD17 leads to a neurodevelopmental disorder characterized by developmental delay, intellectual disability, growth failure, speech impairment, along with other features like feeding difficulties, epilepsy, ophthalmological abnormalities, and joint hypermobility. Analysis suggests that damaging ANKRD17 variants disrupt the stability of the protein and contribute to the observed phenotypes.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

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Article Genetics & Heredity

The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila

Qingliang Sang et al.

Summary: The Hippo signaling pathway plays a critical role in tissue growth and organ size control, with its evolutionarily conserved roles found in various biological processes. In the study, the Drosophila membrane-associated ZO-1 protein Pyd was identified as an upstream regulator of the Hippo pathway to specify photoreceptor subtypes. Pyd was shown to repress Su(dx)'s activity in the Hippo pathway, revealing a new mechanism in post-mitotic neuronal fate specification.

PLOS GENETICS (2021)

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Article Pharmacology & Pharmacy

Inhibiting YAP in Endothelial Cells From Entering the Nucleus Attenuates Blood-Brain Barrier Damage During Ischemia-Reperfusion Injury

Shuaishuai Gong et al.

Summary: The study demonstrated that YAP plays a crucial role in maintaining BBB integrity in ischemic stroke, suggesting its potential as a therapeutic target for modulating BBB integrity in cerebrovascular diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer's Disease

Doris Chen et al.

Summary: FRMD6, also known as Willin, is an upstream regulator of Hippo signaling that modulates actin cytoskeleton dynamics and plays important roles in the nervous system, including neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. Recent studies suggest a potential role for Willin/FRMD6 in Alzheimer's disease through its actions in cellular perturbations related to the pathogenesis of AD.

CELLS (2021)

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Review Cell Biology

Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer's Disease Pathogenesis?

Lucrezia Bruno et al.

Summary: Microglial activation has been linked to the pathogenesis of Alzheimer's disease and other neurodegenerative diseases. Microglia are able to sense and respond to the mechanical properties of their microenvironment. The Hippo pathway may serve as a mechanosensing pathway in microglia and could be a potential therapeutic target pathway for preventing microglial-induced neurodegeneration in AD.

CELLS (2021)

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Review Neurosciences

MicroRNA Dysregulation in Parkinson's Disease: A Narrative Review

Yong Hui Nies et al.

Summary: Parkinson's disease is a severely debilitating neurodegenerative disease that affects the motor system, with mechanisms of pathogenesis still unclear. MicroRNAs play a crucial role in the regulation of PD-associated genes, dopaminergic neuron survival, and inflammation, potentially serving as diagnostic biomarkers and therapeutic tools for PD.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Cell Biology

YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling

Xingxing Xu et al.

Summary: In this study, YAP was found to be downregulated and inactivated in astrocytes of aging and AD model mice, leading to premature senescence of astrocytes. The expression of CDK6 was decreased in YAP knockout astrocytes, and overexpression of CDK6 partially rescued YAP knockout-induced senescence of astrocytes. Activation of YAP signaling by XMU-MP-1 partially rescued astrocyte senescence and improved cognitive function in AD model mice and aging mice.

AGING CELL (2021)

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Article Clinical Neurology

Seizures after Ischemic Stroke: A Matched Multicenter Study

Carolina Ferreira-Atuesta et al.

Summary: Post-stroke seizures are associated with stroke severity, etiology, and location, while early electroencephalogram findings are not predictive of epilepsy. There was no association found between reperfusion treatment and the risks of acute symptomatic seizures or post-stroke epilepsy in the study.

ANNALS OF NEUROLOGY (2021)

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Article Medicine, Research & Experimental

Combined Preconditioning Reduces the Negative Influence of Cerebral Ischemia on the Morphofunctional Condition of CNS

O. S. Levchenkova et al.

Summary: The study found that combined preconditioning has a neuroprotective effect on rats after bilateral ligation of the common carotid artery, improving neuronal survival rates and preventing the formation of necrotic and apoptotic neurons. This was also shown to increase locomotor activity and exploratory behavior in animals.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

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Article Neurosciences

Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy

Susanne Schoch et al.

Summary: SLK plays a critical role in the development of cortical neurons in mice, specifically in the elaboration of higher dendrites and maintaining the balance between excitation and inhibition. Knockdown of SLK leads to loss of inhibitory synapses and functional inhibition in mouse neurons, with potential relevance to human cortical malformations.

JOURNAL OF NEUROSCIENCE (2021)

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Article Neurosciences

Mitochondrial Quality Control in Cerebral Ischemia-Reperfusion Injury

Mimi Wu et al.

Summary: Ischemic stroke is a major cause of death and disability worldwide. Reperfusion therapy is standard for ischemic stroke, but can exacerbate neuronal damage through mitochondrial dysfunction. Mitochondrial quality control and mitophagy play crucial roles in preventing neuronal damage and maintaining a healthy mitochondrial network in cerebral I/R injury.

MOLECULAR NEUROBIOLOGY (2021)

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Review Cell Biology

The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type

Ryszard Pluta et al.

Summary: Recent studies indicate that post-ischemic brain neurodegeneration is associated with altered tau protein, resembling Alzheimer's disease pathology. Changes in tau protein due to cerebral ischemia are linked to various pathological mechanisms such as oxidative stress, apoptosis, and excitotoxicity.

CELLS (2021)

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Review Cell Biology

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Elena V. Mitroshina et al.

Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Clinical Neurology

Seizures and epilepsy in patients with ischaemic stroke

Johann Philipp Zoellner et al.

Summary: With the advancement in stroke treatments, the diagnosis and treatment of post-stroke seizures (PSS) and epilepsy have become more crucial. Various factors, including antiseizure medication, individual patient factors, and potential interactions between stroke and antiseizure treatments, need consideration in PSS treatment. Current research focuses on preventing and understanding PSS, with advances in stroke imaging potentially leading to biomarkers for predicting PSS.

NEUROLOGICAL RESEARCH AND PRACTICE (2021)

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Article Neuroimaging

Focal corticarl dysplasia in epilepsy is associated with GABA increase

Tao Gong et al.

Summary: This study utilized MRI and HERMES to detect metabolic alterations in patients with FCD-associated epilepsy, revealing a significant increase in GABA levels in FCD foci. This suggests that GABA may play a central role in the pathophysiology of FCD patients with epilepsy.

NEUROIMAGE-CLINICAL (2021)

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Review Developmental Biology

The Role of Hippo Signaling Pathway in the Development of the Nervous System

Xifan Li et al.

Summary: The Hippo signaling pathway plays a crucial role in nervous system development, regulating nerve cell proliferation, differentiation, and promoting the development of synapse, corpus callosum, and cortex. The balance of various aspects of the nervous system is vital for normal physiological conditions, and defects in these aspects may lead to nervous system diseases.

DEVELOPMENTAL NEUROSCIENCE (2021)

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Review Cell Biology

Hippo signaling: bridging the gap between cancer and neurodegenerative disorders

Neha Gogia et al.

Summary: Regulation of organ size during development requires a balance between cell proliferation, growth, and cell death. The Hippo signaling pathway plays a crucial role in controlling both cell proliferation and cell death. Neurodegenerative diseases result from progressive death of neuronal population, with no available cure to date.

NEURAL REGENERATION RESEARCH (2021)

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Article Cell Biology

Proinflammation effect of Mst1 promotes BV-2 cell death via augmenting Drp1-mediated mitochondrial fragmentation and activating the JNK pathway

Hong Tian et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Clinical Neurology

From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation

Romain Goulay et al.

TRANSLATIONAL STROKE RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Protective effect of hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α

Mehrnaz Mehrabani et al.

BIOCHEMISTRY AND CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Laminin-Inspired Cell-Instructive Microenvironments for Neural Stem Cells

Daniela Barros et al.

BIOMACROMOLECULES (2020)

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Review Pharmacology & Pharmacy

Protective Effects and Mechanisms of Action of Ulinastatin against Cerebral Ischemia-Reperfusion Injury

Bing Lv et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Biochemistry & Molecular Biology

The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury

Xiaolu Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Proteomic and Genomic Changes in Tau Protein, Which Are Associated with Alzheimer's Disease after Ischemia-Reperfusion Brain Injury

Marzena Ulamek-Koziol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway

Dingzhou Zhou et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Editorial Material Neurosciences

The Dual Role of Microglia in the Progression of Alzheimer's Disease

Kate M. Onuska

JOURNAL OF NEUROSCIENCE (2020)

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Article Medicine, Research & Experimental

The tumor suppressive effect of long non-coding RNA FRMD6-AS2 in uteri corpus endometrial carcinoma

Jing Wang et al.

LIFE SCIENCES (2020)

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Article Multidisciplinary Sciences

YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology

Hikari Tanaka et al.

NATURE COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer

Chenxi Zhao et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Clinical Neurology

PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice

Qingxiu Zhang et al.

TRANSLATIONAL STROKE RESEARCH (2020)

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Review Clinical Neurology

Migraine Aura: Updates in Pathophysiology and Management

Joshua Lai et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2020)

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Article Biochemistry & Molecular Biology

Hippo/YAP Pathway Plays a Critical Role in Effect of GDNF Against Aβ-Induced Inflammation in Microglial Cells

Jie Qing et al.

DNA AND CELL BIOLOGY (2020)

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Review Immunology

The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System

Jinbo Cheng et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Melatonin Regulates Cisplatin Resistance and Glucose Metabolism Through Hippo Signaling in Hepatocellular Carcinoma Cells

Lina Mi et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Cell Biology

A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration

Madison Irwin et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Clinical Neurology

Ischemic injury precipitates neuronal vulnerability in Parkinson's disease: Insights from PINK1 mouse model study and clinical retrospective data

Paola Imbriani et al.

PARKINSONISM & RELATED DISORDERS (2020)

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Review Pharmacology & Pharmacy

Pathophysiology of Ischemic Stroke: Role of Oxidative Stress

Sofia Orellana-Urzua et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Oncology

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Hirohito Yamaguchi et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Cell Biology

D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway

Xingxing Xu et al.

Aging-US (2020)

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Article Pathology

Neuropathology of epilepsy

Suzanne Tran et al.

ANNALES DE PATHOLOGIE (2020)

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Review Cell Biology

The diversity of neuronal phenotypes in rodent and human autonomic ganglia

Uwe Ernsberger et al.

CELL AND TISSUE RESEARCH (2020)

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Review Neurosciences

Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo

Neha Gogia et al.

NEUROBIOLOGY OF DISEASE (2020)

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Review Biochemistry & Molecular Biology

The Diverse Roles of TAO Kinases in Health and Diseases

Chih-Yeu Fang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease

Eun Hee Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Cell Biology

Emerging role of the Hippo pathway in autophagy

Dongying Wang et al.

CELL DEATH & DISEASE (2020)

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Review Neurosciences

The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function

Juan Li et al.

NEURAL PLASTICITY (2020)

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Article Biochemistry & Molecular Biology

A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β (Ser9)-mediated Nrf2 activation

Sha Liao et al.

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Hedging Against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing

Nathan Moreau et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Endocrinology & Metabolism

An overview of biological research on hypoxia-inducible factors (HIFs)

Zhe Liu et al.

ENDOKRYNOLOGIA POLSKA (2020)

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Article Clinical Neurology

Phosphorylation of Tau and alpha-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson's Disease

Shanshan Hu et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)

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Article Clinical Neurology

Why do motor neurons degenerate? Actualization in the pathogenesis of amyotrophic lateral sclerosis

J. Riancho et al.

NEUROLOGIA (2019)

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Article Clinical Neurology

Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways

Yu Shuang Tian et al.

JOURNAL OF NEUROSURGERY (2019)

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Article Medicine, Research & Experimental

Therapeutic effects of melatonin on cerebral ischemia reperfusion injury: Role of Yap-OPA1 signaling pathway and mitochondrial fusion

Na Wei et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Gastroenterology & Hepatology

YAP and the Hippo pathway in cholangiocarcinoma

Takaaki Sugihara et al.

JOURNAL OF GASTROENTEROLOGY (2019)

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Article Biochemistry & Molecular Biology

MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells

Mehtab Khan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Clinical Neurology

Alzheimer's Disease Including Focal Presentations

Nicolas Villain et al.

SEMINARS IN NEUROLOGY (2019)

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Review Neurosciences

The Role of High Mobility Group Box 1 in Ischemic Stroke

Yingze Ye et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Review Neurosciences

Dual Functions of Microglia in Ischemic Stroke

Chuan Qin et al.

NEUROSCIENCE BULLETIN (2019)

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Article Biochemistry & Molecular Biology

Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice

Katarzyna O. Rojek et al.

PLOS BIOLOGY (2019)

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Article Clinical Neurology

Exploration of MST1-Mediated Secondary Brain Injury Induced by Intracerebral Hemorrhage in Rats via Hippo Signaling Pathway

Peng Zhang et al.

TRANSLATIONAL STROKE RESEARCH (2019)

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Article Oncology

Phosphorylation of 14-3-3ζ links YAP transcriptional activation to hypoxic glycolysis for tumorigenesis

Yu Jia et al.

ONCOGENESIS (2019)

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Review Cell Biology

GPCR-Hippo Signaling in Cancer

Jiaqian Luo et al.

CELLS (2019)

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Article Neurosciences

Neuron-Glia Signaling in Synapse Elimination

Daniel K. Wilton et al.

Annual Review of Neuroscience (2019)

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Review Cell Biology

FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response

Candida Fasano et al.

CELLS (2019)

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Article Neurosciences

Combined Ischemic Preconditioning and Resveratrol Improved Blood-brain Barrier Breakdown via Hippo/YAP/TAZ Signaling Pathway

Ganji Hong et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2019)

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Article Immunology

TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain

Xin Wang et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Behavioral Sciences

Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury

Pian Gong et al.

BEHAVIOURAL BRAIN RESEARCH (2019)

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Review Medicine, General & Internal

Parkinson's Disease and Parkinsonism

Michael T. Hayes

AMERICAN JOURNAL OF MEDICINE (2019)

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Review Oncology

Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities

Philamer C. Calses et al.

TRENDS IN CANCER (2019)

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Article Cell Biology

Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

Wazir Abdullahi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

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Article Clinical Neurology

MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF-kB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice

Jie Qu et al.

BEHAVIOURAL NEUROLOGY (2018)

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Review Oncology

Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity

Yuhang Zhou et al.

CANCER LETTERS (2018)

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Article Cell Biology

PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia

Wenying Angela Liu et al.

GENES & DEVELOPMENT (2018)

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Article Neurosciences

Lentivirus-Mediated HDAC3 Inhibition Attenuates Oxidative Stress in APPswe/PS1dE9 Mice

Linjie Yu et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Cell Biology

Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling

Xiaojun Li et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Multidisciplinary Sciences

Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases

Anja Kahl et al.

SCIENTIFIC REPORTS (2018)

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Review Geriatrics & Gerontology

Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System

Sheng Chen et al.

AGING AND DISEASE (2018)

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Article Medicine, Research & Experimental

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Dong Hwan Ho et al.

EXPERIMENTAL NEUROBIOLOGY (2018)

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Review Genetics & Heredity

The Hippo Signaling Network and Its Biological Functions

Jyoti R. Misra et al.

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

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Review Cell Biology

Interplay between YAP/TAZ and Metabolism

Ja Hyun Koo et al.

CELL METABOLISM (2018)

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Article Multidisciplinary Sciences

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Tyler J. Bussian et al.

NATURE (2018)

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Article Medicine, General & Internal

Monitoring Value of Multimodal Magnetic Resonance Imaging in Disease Progression of Amyotrophic Lateral Sclerosis: A Prospective Observational Study

Dong-Chao Shen et al.

CHINESE MEDICAL JOURNAL (2018)

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Article Medicine, General & Internal

Parkinson's disease might increase the risk of cerebral ischemic lesions

In-Uk Song et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2017)

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Review Biochemistry & Molecular Biology

Melatonin and Hippo Pathway: Is There Existing Cross-Talk?

Federica Lo Sardo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Neurosciences

Cognitive Deficits after Cerebral Ischemia and Underlying Dysfunctional Plasticity: Potential Targets for Recovery of Cognition

Holly M. Stradecki-Cohan et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Article Biochemistry & Molecular Biology

Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism

Liangshuai Yuan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Review Biochemistry & Molecular Biology

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Antero Salminen et al.

JOURNAL OF NEUROCHEMISTRY (2017)

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Article Neurosciences

Role of glial cell line-derived neurotrophic factor in the pathogenesis and treatment of mood disorders

Anton S. Tsybko et al.

REVIEWS IN THE NEUROSCIENCES (2017)

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Article Biochemistry & Molecular Biology

Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP

Dawei Zhang et al.

SCIENCE SIGNALING (2017)

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Article Multidisciplinary Sciences

Neuroprotective Effects of CGP3466B on Apoptosis Are Modulated by Protein-L-isoaspartate (D-aspartate) O-methyltransferase/Mst1 Pathways after Traumatic Brain Injury in Rats

Feng Liang et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP

Dawei Zhang et al.

SCIENCE SIGNALING (2017)

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Article Oncology

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

Y. Gao et al.

ONCOGENESIS (2017)

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Article Biotechnology & Applied Microbiology

miR-135b Plays a Neuroprotective Role by Targeting GSK3β in MPP+-Intoxicated SH-SY5Y Cells

Jianlei Zhang et al.

DISEASE MARKERS (2017)

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Article Medicine, Research & Experimental

Effect of Melilotus officinalis extract on the apoptosis of brain tissues by altering cerebral thrombosis and inflammatory mediators in acute cerebral ischemia

Gui-cun Zhao et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Review Clinical Neurology

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

Valeria Calsolaro et al.

ALZHEIMERS & DEMENTIA (2016)

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Article Immunology

Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury

Siqi Zhao et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

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Article Neurosciences

Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway

Yishu Yang et al.

BRAIN RESEARCH (2016)

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Article Pharmacology & Pharmacy

Modulation of neuronal excitability by immune mediators in epilepsy

Valentina Iori et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

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Article Developmental Biology

YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation

Zhihui Huang et al.

DEVELOPMENT (2016)

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Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

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Article Oncology

Expression of netrin-1 by hypoxia contributes to the invasion and migration of prostate carcinoma cells by regulating YAP activity

Haiwen Chen et al.

EXPERIMENTAL CELL RESEARCH (2016)

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Review Cell Biology

Mechanisms of Hippo pathway regulation

Zhipeng Meng et al.

GENES & DEVELOPMENT (2016)

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Article Neurosciences

Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex

Zhihui Huang et al.

JOURNAL OF NEUROSCIENCE (2016)

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Article Neurosciences

Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

Xiaoyu Yang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

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Article Developmental Biology

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development

Yelda Serinagaoglu et al.

DEVELOPMENTAL BIOLOGY (2015)

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Article Cell Biology

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wenqi Wang et al.

NATURE CELL BIOLOGY (2015)

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Article Geriatrics & Gerontology

Subcortical structures in amyotrophic lateral sclerosis

Henk-Jan Westeneng et al.

NEUROBIOLOGY OF AGING (2015)

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Article Multidisciplinary Sciences

Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability

Qi Qi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Clinical Neurology

Current Therapeutic Options in Sturge-Weber Syndrome

Anne Comi

SEMINARS IN PEDIATRIC NEUROLOGY (2015)

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Article Multidisciplinary Sciences

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Zhipeng Meng et al.

NATURE COMMUNICATIONS (2015)

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Article Clinical Neurology

Impairment of Paravascular Clearance Pathways in the Aging Brain

Benjamin T. Kress et al.

ANNALS OF NEUROLOGY (2014)

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Article Behavioral Sciences

Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epilepsy

Zlatina Petkova et al.

EPILEPSY & BEHAVIOR (2014)

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Article Neurosciences

BMP2-SMAD Signaling Represses the Proliferation of Embryonic Neural Stem Cells through YAP

Minghui Yao et al.

JOURNAL OF NEUROSCIENCE (2014)

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Article Multidisciplinary Sciences

Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts

Susana Moleirinho et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS

Jae Keun Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Cell Biology

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

P. Sanphui et al.

CELL DEATH & DISEASE (2013)

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Review Biochemistry & Molecular Biology

Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling

Alexander Hergovich

CELL AND BIOSCIENCE (2013)

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Review Oncology

The Hippo pathway and human cancer

Kieran F. Harvey et al.

NATURE REVIEWS CANCER (2013)

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Article Biochemistry & Molecular Biology

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Fa-Xing Yu et al.

CELL (2012)

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Review Chemistry, Medicinal

Targeting Oxidative Stress Component in the Therapeutics of Epilepsy

Faizul Azam et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)

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Article Neurosciences

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

Sandra Moreira Rocha et al.

NEUROBIOLOGY OF DISEASE (2012)

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Article Neurosciences

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

Lei Xiao et al.

JOURNAL OF NEUROSCIENCE (2011)

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Article Multidisciplinary Sciences

Forced Notch Signaling Inhibits Commissural Axon Outgrowth in the Developing Chick Central Nerve System

Ming Shi et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Activation of JNK Signaling Mediates Amyloid-β-Dependent Cell Death

Meghana Tare et al.

PLOS ONE (2011)

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Article Clinical Neurology

Gray matter perfusion correlates with disease severity in ALS

Randall R. Rule et al.

NEUROLOGY (2010)

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Article Biochemistry & Molecular Biology

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

Zengqiang Yuan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Neurosciences

Progressive Decrease in the Level of YAPdeltaCs, Prosurvival Isoforms of YAP, in the Spinal Cord of Transgenic Mouse Carrying a Mutant SOD1 Gene

Nobutoshi Morimoto et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2009)

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Review Neurosciences

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

Manuel Yepes et al.

TRENDS IN NEUROSCIENCES (2009)

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Article Neurosciences

Bim is elevated in Alzheimer's disease neurons and is required for β-amyloid-induced neuronal apoptosis

Subhas C. Biswas et al.

JOURNAL OF NEUROSCIENCE (2007)

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Review Biochemistry & Molecular Biology

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis

L. Van den Bosch et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)

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Article Biochemistry & Molecular Biology

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

Maria K. Lehtinen et al.

CELL (2006)

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Article Biochemistry & Molecular Biology

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP

JB Huang et al.

CELL (2005)

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Article Biochemistry & Molecular Biology

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

EH Chan et al.

ONCOGENE (2005)

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Article Biochemistry & Molecular Biology

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

M Praskova et al.

BIOCHEMICAL JOURNAL (2004)

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Article Biochemistry & Molecular Biology

Mapping of MST1 kinase sites of phosphorylation - Activation and autophosphorylation

H Glantschnig et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Neurosciences

The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system

AJ Herrera et al.

NEUROBIOLOGY OF DISEASE (2000)

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An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases

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