☆ 4.7 Review

Masitinib: The promising actor in the next season of the Amyotrophic Lateral Sclerosis treatment series

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Clinical Neurology

A randomized placebo-controlled phase 3 study of mesenchymal stem cells induced to secrete high levels of neurotrophic factors in amyotrophic lateral sclerosis

Merit E. Cudkowicz et al.

Summary: This study evaluated the efficacy of mesenchymal stem cells induced to secrete neurotrophic factors in slowing the progression of ALS. The results suggest that this therapy may have a positive effect on patients with less severe disease, but did not reach statistical significance on the primary endpoint.

MUSCLE & NERVE (2022)

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Article Multidisciplinary Sciences

Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation

Narges Daneshafrooz et al.

Summary: In this study, a meta-analysis was conducted to identify and validate potential molecular biomarkers associated with the onset and progression of amyotrophic lateral sclerosis (ALS). The results revealed that let-7f-5p and miR-338-3p may serve as robust plasma biomarkers for the diagnosis and potential therapeutic targets of ALS.

SCIENTIFIC REPORTS (2022)

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Article Clinical Neurology

Efficacy and Safety of Masitinib in Progressive Forms of Multiple Sclerosis A Randomized, Phase 3, Clinical Trial

Patrick Vermersch et al.

Summary: The study demonstrated that masitinib has benefits for patients with progressive MS, particularly for those with PPMS and nSPMS. Further phase 3 studies will be initiated to substantiate these findings.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2022)

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Article Biochemistry & Molecular Biology

Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis

Belgin Sever et al.

Summary: Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating neurodegenerative disorder with limited treatment options. Recent studies have identified multiple pathological mechanisms, including oxidative stress, mitochondrial dysfunction, and excitotoxicity, providing potential directions for future ALS treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Clinical Neurology

Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial

Sabrina Paganoni et al.

Summary: Early use of PB/TURSO can prolong tracheostomy/ventilation-free survival in ALS patients and delay the first hospitalization.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2022)

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Article Clinical Neurology

Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes

Sabrina Paganoni et al.

Summary: This study utilized the RPSFTM survival analysis method to analyze data from the CENTAUR trial in ALS, and the results showed a significant survival benefit of PB and TURSO compared to placebo. The findings of this study may contribute to the clinical application of observed survival outcomes in future ALS crossover trials.

MUSCLE & NERVE (2022)

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Article Multidisciplinary Sciences

Large-scale analysis of MicroRNA expression in motor neuron-like cells derived from human umbilical cord blood mesenchymal stem cells

Davood Sanooghi et al.

Summary: This study investigated the regulation of miRNAs during the differentiation of human umbilical cord blood mesenchymal stem cells (CB-MSCs) into motor neuron-like cells. The results showed that miR-9-5p and miR-324-5p were significantly up-regulated during the early stage of differentiation, while miR-137 and miR-let-7b were down-regulated in the absence of retinoic acid (RA) and sonic hedgehog (Shh). Additionally, several novel miRNAs involved in cholinergic, Hedgehog, MAPK, and JAK-STAT signaling pathways were detected. Further studies are needed to validate the functions of these miRNAs during motor neuron generation and maturation.

SCIENTIFIC REPORTS (2022)

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Article Clinical Neurology

Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis A Randomized Clinical Trial

Ryosuke Oki et al.

Summary: This study aimed to validate the efficacy and safety of ultrahigh-dose methylcobalamin for patients with early-stage ALS. The results showed that methylcobalamin was effective in slowing functional decline in ALS patients, and it was safe to use during the 16-week treatment period.

JAMA NEUROLOGY (2022)

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Article Medicine, General & Internal

Acute polyneuropathy as the main manifestation of primary Sjogren's syndrome: A case report

Arsh Haj Mohamad Ebrahim Ketabforoush et al.

Summary: In this case report, we describe a patient with Sjogren's syndrome who presented with an acute motor-predominant polyneuropathy resembling Guillain-Barre syndrome. Further investigation revealed sicca symptoms that had been present for months. A thorough history should be taken to avoid missed diagnosis.

CLINICAL CASE REPORTS (2022)

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Article Chemistry, Medicinal

Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib

Bethany D. Latham et al.

Summary: This study identifies that the metabolic activation of masitinib is primarily catalyzed by P450 3A4 and 2C8 enzymes, with minor contributions from P450 3A5 and 2D6. These findings provide further insight into the pathways involved in the generation of reactive, potentially toxic metabolites of masitinib.

CHEMICAL RESEARCH IN TOXICOLOGY (2022)

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Review Medicine, Research & Experimental

Modulation of autophagy by melatonin via sirtuins in stroke: From mechanisms to therapies

Fereshteh Azedi et al.

Summary: Sirtuins play an important role in the neural cell fate following stroke, and mechanisms related to stroke include oxidative stress, apoptosis, necrosis, and autophagy. Recent studies have shown that melatonin can modulate autophagy by changing sirtuin pathways, thus affecting stroke treatment.

LIFE SCIENCES (2022)

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Article Medicine, General & Internal

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

Timothy M. Miller et al.

Summary: This study examined the use of tofersen in patients with SOD1 ALS and found that it can reduce protein concentrations in the cerebrospinal fluid and plasma, but does not improve clinical outcomes and is associated with adverse events. Further investigation is needed to evaluate the effects of early initiation of tofersen.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Clinical Neurology

Risk factors for amyotrophic lateral sclerosis: A regional United States case-control study

Angeline S. Andrew et al.

Summary: The study found that head trauma, electrical burns, and hobbies involving lead are associated with an increased risk of ALS. Environmental factors may play a role in the onset of ALS, highlighting the need for future research to assess causality, biological mechanisms, and find prevention or treatment opportunities.

MUSCLE & NERVE (2021)

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Article Clinical Neurology

Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis

Sabrina Paganoni et al.

Summary: In the CENTAUR trial for ALS, orally administered PB-TURSO significantly slowed functional decline and a long-term survival analysis showed that participants receiving PB-TURSO treatment had a median survival 6.5 months longer than those on placebo. These results suggest that PB-TURSO has both functional and survival benefits in ALS.

MUSCLE & NERVE (2021)

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Review Biochemistry & Molecular Biology

Immune Signaling Kinases in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

Raquel Garcia-Garcia et al.

Summary: ALS and FTD are the most common neurodegenerative diseases in adults, sharing clinical, genetic, and pathological similarities, characterized by progressive neuronal loss and chronic inflammation mediated by immune signaling kinases. The role of immune signaling kinases in determining neuroprotective or neurodegenerative states in ALS and FTD is crucial for understanding the underlying mechanisms of these disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Medicinal

Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis

HaEun Cho et al.

Summary: ALS, also known as Lou Gehrig's disease, is a deadly neurodegenerative disease that affects muscle control. Common clinical symptoms include muscle weakness, behavioral changes, speech dysfunction, and cognitive difficulties. Research suggests that mutations in genes such as SOD1 and C9orf72, as well as excessive ROS, may contribute to ALS. The newly approved antioxidant drug, edaravone, has shown potential in slowing disease progression by reducing ROS and protecting neurons.

PHARMACEUTICALS (2021)

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Article Clinical Neurology

Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis

Andrew Hannaford et al.

Summary: The study found that the Gold Coast criteria had high sensitivity in the diagnosis of ALS, with consistent accuracy across different subgroups based on disease origin, duration, and functional impairments. In atypical ALS phenotypes, the Gold Coast criteria showed higher sensitivity and specificity.

ANNALS OF NEUROLOGY (2021)

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Article Clinical Neurology

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study) : a randomised, double-blind, placebo-controlled phase 3 trial

Merit Cudkowicz et al.

Summary: The study found that levosimendan was not superior to placebo in maintaining respiratory function in a broad population with amyotrophic lateral sclerosis. While generally well tolerated, levosimendan had a higher frequency of adverse events such as increased heart rate and headache compared to placebo. Further evaluation is needed to determine if there is a clinically relevant subgroup that may respond to the drug.

LANCET NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress

Swetha Medchalmi et al.

Summary: Mutations in OPTN, such as the 2-bp insertion, can lead to aberrant protein sequences, causing diseases like glaucoma and ALS. This mutation induces cell death, localizes mainly in the nucleus, and activates ER stress through Tbk1.

FEBS JOURNAL (2021)

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Review Clinical Neurology

Therapeutic news in ALS

P. Corcia et al.

Summary: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron death, with limited treatment options available. Despite 30 years of trials, no curative drug has been found for ALS.

REVUE NEUROLOGIQUE (2021)

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Article Clinical Neurology

MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design

Bjorn Oskarsson et al.

Summary: ALS is a neurodegenerative disease characterized by motor neuron loss, for which therapeutic breakthroughs have been limited. MN-166 has shown neuroprotective effects in models of ALS through various mechanisms, and early studies suggest potential benefits for ALS patients. COMBAT-ALS is an ongoing study aiming to evaluate the efficacy of MN-166 on function, muscle strength, quality of life, and survival in ALS patients.

NEURODEGENERATIVE DISEASE MANAGEMENT (2021)

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Article Clinical Neurology

Gold Coast diagnostic criteria: Implications for ALS diagnosis and clinical trial enrollment

Steve Vucic et al.

Summary: The diagnostic criteria for ALS have been simplified with the Gold Coast criteria, which have increased sensitivity, maintained accuracy, and differentiated atypical phenotypes. It is proposed that these criteria should be incorporated into routine practice and clinical trial settings.

MUSCLE & NERVE (2021)

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Article Clinical Neurology

Long-term survival analysis of masitinib in amyotrophic lateral sclerosis

Jesus S. Mora et al.

Summary: The study found that oral masitinib may prolong survival in ALS patients by over 2 years compared to placebo, especially if treatment starts early and in patients with slower disease progression.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2021)

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Article Genetics & Heredity

In vitro characterization of human bone marrow mesenchymal stem cell-derived motor neurons induced by epigenetic modifiers

Davood Sanooghi et al.

Summary: The study focuses on the differentiation of hBM-MSCs into MN-like cells using Shh and RA, evaluating the expression of MN-related genes and epigenetic regulatory genes. Results show significant upregulation of ChAT, Islet-1, EZH-2, and P300 in induced cells compared to controls, indicating the importance of epigenetic modifiers in regulating motor neuron differentiation. No significant change was observed in MNX-1 expression between treated and control groups.

EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS (2021)

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Article Clinical Neurology

Effect of edaravone therapy in Korean amyotrophic lateral sclerosis (ALS) patients

Jin-Mo Park et al.

NEUROLOGICAL SCIENCES (2020)

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Review Pharmacology & Pharmacy

Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)

Elena Abati et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

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Article Biochemistry & Molecular Biology

Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy

Yanming Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Clinical Neurology

Amyotrophic lateral sclerosis: a clinical review

P. Masrori et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Review Pathology

Common mutations of interest in the diagnosis of amyotrophic lateral sclerosis: how common are common mutations in ALS genes?

Benedetta Perrone et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2020)

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Article Neurosciences

Effects of Chronic Masitinib Treatment in APPswe/PSEN1dE9 Transgenic Mice Modeling Alzheimer's Disease

Tengfei Li et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Medicine, Research & Experimental

Importance of the serum biochemical parameters as potential biomarkers for rapid diagnosis and evaluating preclinical stage of ALS

Duygu Aydemir et al.

MEDICAL HYPOTHESES (2020)

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Review Clinical Neurology

ALS : Management Problems

Jonathan R. Brent et al.

NEUROLOGIC CLINICS (2020)

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Article Medicine, General & Internal

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

Timothy Miller et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Immunology

Ibudilast, a Phosphodiesterase Inhibitor and Toll-Like Receptor-4 Antagonist, Improves Hemorrhagic Shock and Reperfusion-Induced Left Ventricular Dysfunction by Reducing Myocardial Tumor Necrosis Factor α

Nan-Chun Wu et al.

TRANSPLANTATION PROCEEDINGS (2020)

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Review Pharmacology & Pharmacy

Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis

Pablo Bascunana et al.

DRUGS IN R&D (2020)

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Review Neurosciences

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis

Terry R. Suk et al.

MOLECULAR NEURODEGENERATION (2020)

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Article Medicine, General & Internal

Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis

Sabrina Paganoni et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Neurosciences

Muscle fiber-type specific terminal Schwann cell pathology leads to sprouting deficits following partial denervation in SOD1G93A mice

Julia M. Harrison et al.

NEUROBIOLOGY OF DISEASE (2020)

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Review Neurosciences

The role of mitochondria in amyotrophic lateral sclerosis

Emma F. Smith et al.

NEUROSCIENCE LETTERS (2019)

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Article Neurosciences

Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders

Alireza Mohammadi et al.

MOLECULAR NEUROBIOLOGY (2019)

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Article Biochemistry & Molecular Biology

The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing

Maeve Tischbein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Review Clinical Neurology

Epidemiology of amyotrophic lateral sclerosis: an update of recent literature

Elisa Longinetti et al.

CURRENT OPINION IN NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques

Mehdi A. J. van den Bos et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Clinical Neurology

Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial

Ammar Al-Chalabi et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

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Review Neurosciences

Revisiting the role of the innate immune complement system in ALS

Sandra E. Parker et al.

NEUROBIOLOGY OF DISEASE (2019)

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Editorial Material Biochemistry & Molecular Biology

Lou Gehrig's Disease (ALS): UBQLN2 Mutations Strike Out of Phase

Nicole Higgins et al.

STRUCTURE (2019)

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Article Neurosciences

Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase

Fereshteh Azedi et al.

BRAIN RESEARCH (2019)

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Article Cell Biology

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Oliver H. Tam et al.

CELL REPORTS (2019)

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Article Cell Biology

Small molecule of sphingosine as a rescue of dopaminergic cells: A cell therapy approach in neurodegenerative diseases therapeutics

Shima Tavakol et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Clinical Neurology

Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study

Ryuji Kaji et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

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Review Public, Environmental & Occupational Health

Amyotrophic Lateral Sclerosis Descriptive Epidemiology: The Origin of Geographic Difference

Giancarlo Logroscino et al.

NEUROEPIDEMIOLOGY (2019)

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Review Clinical Neurology

Decision-making among patients and their family in ALS care: a review

Geraldine Foley et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2018)

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Review Nutrition & Dietetics

How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

Kazutoshi Watanabe et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2018)

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Article Biochemistry & Molecular Biology

Amyotrophic lateral sclerosis: The complement and inflammatory hypothesis

Anne-Lene Kjaeldgaard et al.

MOLECULAR IMMUNOLOGY (2018)

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Article Clinical Neurology

Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS

Michael Benatar et al.

NEUROLOGY (2018)

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Review Immunology

Altered Functions and interactions of Glaucoma-Associated Mutants of Optineurin

Ghanshyam Swarup et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma

Reka P. Toth et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Prevalence of Amyotrophic Lateral Sclerosis - United States, 2014

Paul Mehta et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2018)

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Article Medicine, Research & Experimental

Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS

Emiliano Trias et al.

JCI INSIGHT (2018)

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Article Biochemistry & Molecular Biology

Evaluation of of motor neuron differentiation potential of human umbilical cord blood- derived mesenchymal stem cells, in vitro

Behnam Yousefi et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2017)

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Article Medicine, General & Internal

Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study

Olivier Lortholary et al.

LANCET (2017)

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Review Medicine, General & Internal

Amyotrophic lateral sclerosis

Michael A. van Es et al.

LANCET (2017)

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Editorial Material Clinical Neurology

Edaravone: a new treatment for ALS on the horizon?

Orla Hardiman et al.

LANCET NEUROLOGY (2017)

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Article Clinical Neurology

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

Koji Abe et al.

LANCET NEUROLOGY (2017)

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Article Clinical Neurology

Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability

James D. Berry et al.

MUSCLE & NERVE (2017)

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Review Cell Biology

The interaction of genetics and environmental toxicants in amyotrophic lateral sclerosis: results from animal models

Roger B. Sher

NEURAL REGENERATION RESEARCH (2017)

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Review Cell Biology

Current view and perspectives in amyotrophic lateral sclerosis

Stephane Mathis et al.

NEURAL REGENERATION RESEARCH (2017)

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Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial

Richard Smith et al.

NEUROTHERAPEUTICS (2017)

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Review Neurosciences

Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

Ming-Dong Wang et al.

NEUROTOXICOLOGY (2017)

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Article Clinical Neurology

Clinical features of amyotrophic lateral sclerosis and their prognostic value

C. Tard et al.

REVUE NEUROLOGIQUE (2017)

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Article Clinical Neurology

Genetics of amyotrophic lateral sclerosis

P. Corcia et al.

REVUE NEUROLOGIQUE (2017)

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Review Geriatrics & Gerontology

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

Dmitry Petrov et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

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Article Clinical Neurology

Home care organization impacts patient management and survival in ALS

Sylvie Lavernhe et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2017)

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Article Clinical Neurology

Introduction to supplement: the current status of treatment for ALS

Robert G. Miller et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2017)

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Review Immunology

Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic implications

Jia Liu et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Clinical Neurology

Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials

Syed I. Khalid et al.

FRONTIERS IN NEUROLOGY (2017)

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Review Pharmacology & Pharmacy

Effects of Carotenoids on Health: Are All the Same? Results from Clinical Trials

Arrigo F. G. Cicero et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

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Article Clinical Neurology

C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia

Yoshitsugu Aoki et al.

BRAIN (2017)

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Article Clinical Neurology

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

A. E. Elia et al.

EUROPEAN JOURNAL OF NEUROLOGY (2016)

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Article Anesthesiology

The Effects of the Toll-Like Receptor 4 Antagonist, Ibudilast, on Sevoflurane's Minimum Alveolar Concentration and the Delayed Remifentanil-Induced Increase in the Minimum Alveolar Concentration in Rats

Daniel Ruiz-Perez et al.

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Current Therapy of Drugs in Amyotrophic Lateral Sclerosis

Haiyan Lu et al.

CURRENT NEUROPHARMACOLOGY (2016)

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Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting

Elisse C. Browne et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Enhancing Approaches to the Identification and Management of Pseudobulbar Affect

David W. Crumpacker

JOURNAL OF CLINICAL PSYCHIATRY (2016)

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Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Emiliano Trias et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Immunology

Complement activation at the motor end-plates in amyotrophic lateral sclerosis

Nawal Bahia El Idrissi et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Review Clinical Neurology

Amyotrophic lateral sclerosis and motor neuron syndromes in Asia

N. Shahrizaila et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

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Article Biochemistry & Molecular Biology

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

Wenzhang Wang et al.

NATURE MEDICINE (2016)

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Review Clinical Neurology

Pathophysiological and diagnostic implications of cortical dysfunction in ALS

Nimeshan Geevasinga et al.

NATURE REVIEWS NEUROLOGY (2016)

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Article Clinical Neurology

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

Rosa Luisa Potenza et al.

NEUROTHERAPEUTICS (2016)

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Article Biochemistry & Molecular Biology

Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone

Akio Fujisawa et al.

REDOX REPORT (2016)

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Article Multidisciplinary Sciences

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040

Karissa C. Arthur et al.

NATURE COMMUNICATIONS (2016)

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Review Neurosciences

Genotype-phenotype correlations of amyotrophic lateral sclerosis

Hong-Fu Li et al.

TRANSLATIONAL NEURODEGENERATION (2016)

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Review Medicine, Research & Experimental

Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS

Junghee Lee et al.

EXPERIMENTAL NEUROBIOLOGY (2016)

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Article Multidisciplinary Sciences

Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats

Masamichi Okubo et al.

PLOS ONE (2016)

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Review Clinical Neurology

Natural history and clinical features of sporadic amyotrophic lateral sclerosis in China

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An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

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Levosimendan Enhances Force Generation of Diaphragm Muscle from Patients with Chronic Obstructive Pulmonary Disease

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Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase

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Electrodiagnostic criteria for diagnosis of ALS

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Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

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Clinical characteristics and survival pattern of 1153 patients with amyotrophic lateral sclerosis: Experience over 30 years from India

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Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

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Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia

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