☆ 4.7 Review

The macrophage polarization in inflammatory dermatosis and its potential drug candidates

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Allergy

Hsa_circ_0004287 inhibits macrophagemediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis

Lan Yang et al.

Summary: This study identified a functional unknown circRNA hsa_circ_0004287 that is upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients and mainly expressed by macrophages under inflammatory conditions. Hsa_circ_0004287 reduces the stability of its host gene MALAT1 and inhibits M1 macrophage activation, thereby alleviating skin inflammation in AD and psoriasis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells

Qiu-kai Lu et al.

Summary: Apremilast effectively ameliorated the pathological manifestations of systemic sclerosis by suppressing the recruitment and activation of inflammatory cells, and reducing the secretion of inflammatory cytokines. Apremilast could also dose-dependently inhibit the activation of M1 and T cells by promoting the phosphorylation of CREB.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Nutrition & Dietetics

Faeces from malnourished colorectal cancer patients accelerate cancer progression

Xu Chao et al.

Summary: This study investigates the role of gut microbiota in colorectal cancer (CRC) under malnutrition conditions. The researchers found significant variations in the gut microbiota among patients with different nutritional statuses. Specific microbiota species were identified as potential diagnostic biomarkers for malnutrition and indicators of poor prognosis in CRC. Furthermore, the study demonstrated that after fecal microbiota transplantation, B cells and macrophages were recruited to activate specific tumor immunity in CRC. These findings highlight the importance of gut microbiota in CRC progression and its potential as a diagnostic tool.

CLINICAL NUTRITION (2022)

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Seungmagalgeun-Tang, a Traditional Herbal Formula, Alleviates Skin Inflammation and Depression-Like Behavior in Atopic Dermatitis Mice under Sleep Deprivation Conditions

Ly Thi Huong Nguyen et al.

Evidence-based Complementary and Alternative Medicine (2022)

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Review Immunology

Metabolic Regulation of Macrophage Activation

Ourania Kolliniati et al.

Summary: Macrophages, as central mediators of innate immune responses, adapt to different environments and nutritional resources by utilizing energy at both normoxic and hypoxic conditions and modulating signaling pathways to shape different activation phenotypes. Systemic changes in diseases can also affect macrophage metabolism, resulting in altered activation phenotypes in adipose tissue or in the periphery.

JOURNAL OF INNATE IMMUNITY (2022)

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Article Cell Biology

Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes

Catherine B. Anders et al.

Summary: The study utilized an ex vivo model to generate 6 distinct functional phenotypes of macrophages, profiling them based on cell surface markers, secreted proteins, gene expression, and metabolites. The research identified unique metabolic profiles for each phenotype, grouping them into inflammatory and wound resolution categories, with key differences observed in metabolic pathways. Ultimately, the integration of metabolomics provided a comprehensive understanding of macrophage diversity and functional plasticity.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Two glycoproteins from medicinal insect Periplaneta americana (L.) promote diabetic wound healing via macrophage polarization modulation

Lan Pang et al.

Summary: This study isolated and characterized two glycoproteins from the medicinal insect Periplaneta americana. The glycoproteins showed potential in promoting wound healing, as evidenced by their anti-inflammatory effects and ability to accelerate wound healing in diabetic mice.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Schwann cells contribute to keloid formation

Martin Direder et al.

Summary: This study identifies a unique population of Schwann cells in keloids and highlights the interaction between Schwann cells and macrophages in keloid formation.

MATRIX BIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis

Tingjun Tao et al.

Summary: This study aimed to investigate the inhibitory effects of shikonin combined with methotrexate on psoriasis progression by regulating macrophage polarization. The results showed that this combination treatment reduced erythema and PASI scores, decreased backer score and epidermal thickness, and regulated macrophage polarization, providing protective effects against psoriasis.

BIOENGINEERED (2022)

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Article Dermatology

Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin

Leonie Gather et al.

Summary: This study found that there is an increase in the number of macrophages in aged human skin, with a more proinflammatory phenotype. Additionally, the aging microenvironment drives the proinflammatory phenotype of skin macrophages, which negatively affects the expression of extracellular matrix proteins by fibroblasts.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Chemistry, Medicinal

Pharmacological effects of Eleutherococcus senticosus on the neurological disorders

Xi-Tao Li et al.

Summary: This review summarizes the traditional uses and therapeutic effects of Eleutherococcus senticosus in the treatment of fatigue, depression, Alzheimer's disease, Parkinson's disease, and cerebral ischemia, and discusses the underlying mechanisms involved.

PHYTOTHERAPY RESEARCH (2022)

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Article Plant Sciences

Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models

Lan Wang et al.

Summary: This study developed a modified Huang-Lian-Jie-Du Decoction (MHLJDD) and demonstrated its potential efficacy in treating atopic dermatitis (AD) using mouse models. MHLJDD improved AD-like symptoms, including skin thickening, dryness, and inflammation, and regulated gut microbiota.

PHYTOMEDICINE (2022)

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Article Biochemistry & Molecular Biology

Anti-atopic dermatitis effects of Parasenecio auriculatus via simultaneous inhibition of multiple inflammatory pathways

Yujin Kwon et al.

Summary: The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. This study identified a plant extract (PE) with anti-inflammatory effects on multiple cell types involved in AD development. The PE suppressed degranulation and cytokine production, regulated FceRI and TLR4 signaling, and improved skin structure in an AD mouse model. The findings suggest that this PE could be a potential treatment for AD.

BMB REPORTS (2022)

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Article Biochemistry & Molecular Biology

Lycopus lucidus Turcz Water Extract Ameliorates the Metabolic Disorder by Up-Regulated Major Urinary Protein Expression in High-Fat Diet-Induced Obesity

Youngji Han et al.

Summary: This study found that Lycopus lucidus Turcz (LT) can improve obesity by increasing energy expenditure and promoting fatty oxidation. LT can also improve dyslipidemia, hepatic steatosis, and insulin resistance, and reduce inflammation and collagen accumulation.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription

Jing Wang et al.

Summary: This study reveals that KLF4 can inhibit fibrosis by suppressing the transdifferentiation of fibroblasts into myofibroblasts. The downregulation of KLF4 in hypertrophic scars suggests its potential regulatory role in scar formation. Additionally, KLF4 is associated with BMP4 in inhibiting skin fibrosis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy

Shunqin Zhu et al.

Summary: Artemisinin and its derivatives are potential anticancer drugs that induce cancer cell apoptosis, promote cell cycle arrest and autophagy, and inhibit cancer cell invasion and migration. They also increase intracellular Reactive Oxygen Species (ROS) levels, leading to ferroptosis, a new form of cell death considered as a cancer suppressor and a novel mechanism for cancer therapy.

CURRENT MEDICINAL CHEMISTRY (2021)

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Article Immunology

TLR7 endogenous ligands remodel glycolytic macrophages and trigger skin-to-joint crosstalk in psoriatic arthritis

Katrien Van Raemdonck et al.

Summary: This study reveals that miR-Let7b activates TLR7 and induces skin inflammation, exacerbating joint inflammation in a PsA-like preclinical model. TLR7 agonist R837 promotes metabolic reprogramming in macrophages and enhances the expression of IL-1 beta, IL-6, and IL-12, facilitating myeloid-to-T-cell crosstalk in mice. Inhibiting glycolysis reverses TLR7-driven inflammation in myeloid and lymphoid cells, suggesting a potential therapeutic target for PsA.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

The therapeutic effects of naringenin on bronchial pneumonia in children

Wenjing Yao et al.

Summary: Naringenin shows potential as a treatment for bronchial pneumonia in children due to its anti-inflammatory and antimicrobial activities, improving health conditions of patients.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

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Review Biochemistry & Molecular Biology

Luteolin as a modulator of skin aging and inflammation

Fabian Gendrisch et al.

Summary: Luteolin, a flavonoid found in plants, possesses antioxidant and anti-inflammatory activities, modulating various inflammatory processes in the skin. It shows promise in the development of formulations for treating inflammatory skin diseases.

BIOFACTORS (2021)

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Article Pharmacology & Pharmacy

Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis

Zi-Xuan Wang et al.

Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Plant Sciences

Naoxintong restores ischemia injury and inhibits thrombosis via COX2-VEGF/NFκB signaling

Zhihao Wang et al.

Summary: The study found that NXT treatment could reduce ischemic vascular injury, increase cell viability, and decrease apoptosis. RNA-seq analysis identified 183 differentially expressed genes (DEGs) in NXT treated cells, with COX2 being identified as an important target for NXT in restoring vascular injury.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway

Hui Li et al.

Summary: Naringenin (Nar) exerts cytoprotective effects against homocysteine-induced endothelial damage (ED) by activating AMPK alpha/Sirt1 signaling pathway, restoring mitochondrial Ca2+ balance, reducing reactive oxygen species (ROS) production, and increasing nitric oxide (NO) generation, ultimately ameliorating ED.

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Medicine, Research & Experimental

Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease

I-Jung Lee et al.

Summary: Huang Lian Jie Du Tang is used to treat Parkinson's disease and this study found that it can mitigate paraquat-induced cell death by regulating mitophagy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Chemistry, Medicinal

Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice

Jung Eun Seol et al.

Summary: Echinochrome A injection significantly decreased transepidermal water loss, attenuated tissue inflammatory changes and collagen degradation, and reduced the relative expression of matrix metalloproteinase, tryptase, and chymase. Overall, these results suggest that Ech A protects against UVB-induced photoaging by lowering collagen degradation and inflammatory cell infiltration in both functional and histological aspects.

MARINE DRUGS (2021)

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Article Chemistry, Medicinal

Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression

Hyeong Rok Yun et al.

Summary: The study demonstrated the anti-inflammatory effects of Echinochrome A (Ech A) extracted from sea urchins in alleviating atopic dermatitis (AD) like skin lesions in an NC/Nga mouse model. Ech A treatment improved clinical symptoms of AD, reduced water loss, enhanced stratum corneum hydration, and suppressed inflammatory response and cytokine expression in skin lesions.

MARINE DRUGS (2021)

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Article Oncology

Lycopus lucidus Turcz ameliorates DNCB-induced atopic dermatitis in BALB/c mice

Ga-Yul Min et al.

Summary: The study found that Lycopus lucidus Turcz (LLT) has a beneficial effect on dermatitis by inhibiting infiltration of inflammatory cells in skin tissue and suppressing the expression of pro-inflammatory cytokines. LLT also showed anti-inflammatory properties in both keratinocyte and macrophage cell models. Ultimately, LLT may be a promising candidate for the treatment of inflammatory dermatitis.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

Quercetin exerts antidepressant and cardioprotective effects in estrogen receptor α-deficient female mice via BDNF-AKT/ERK1/2 signaling

Guoli Wang et al.

Summary: The study found that quercetin can simultaneously reverse depression-like and cardiac dysfunction induced by ER alpha deficiency in female mice, possibly exerting antidepressant and cardioprotective effects through the activation of the BDNF-TrkB-AKT/ERK1/2 pathway.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Emodin-A natural anthraquinone derivative with diverse pharmacological activities

Ruchi Badoni Semwal et al.

Summary: Emodin is a natural anthraquinone derivative that acts as a protein tyrosine kinase inhibitor and an anticancer drug, showing activity against various tumor cells. It is increasingly being studied for its potential in combination chemotherapy and its broad range of therapeutic activities.

PHYTOCHEMISTRY (2021)

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Article Medicine, Research & Experimental

TRPA1 deficiency alleviates inflammation of atopic dermatitis by reducing macrophage infiltration

Dan Zeng et al.

Summary: The study aimed to investigate the role of TRPA1 in the pathogenesis of AD. Experimental AD-like skin lesions were induced in mice using 2,4-dinitrochlorobenzene. Mice lacking TRPA1 showed lower dermatitis severity, epidermal hyperplasia, and inflammatory markers compared to wild-type mice. Treatment with a TRPA1 antagonist also alleviated AD-like symptoms in mice.

LIFE SCIENCES (2021)

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Article Cell Biology

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

Jiahao He et al.

Summary: The study identified that Piezo1 channel is overexpressed in myofibroblasts of hypertrophic scar (HS) tissues and plays a regulatory role in fibroblasts, thus participating in HS formation. Piezo1 activity enhances various cellular biological behaviors in response to mechanical stretch in dermal fibroblasts, including proliferation, motility, and differentiation. Additionally, blocking Piezo1 with GsMTx4 peptide injection protected rats from stretch-induced HS formation, suggesting Piezo1 as a potential therapeutic target for HS.

CELL DEATH & DISEASE (2021)

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Article Medical Laboratory Technology

Macrophage polarization and diabetic wound healing

Amanda E. Louiselle et al.

Summary: Research has shown that the polarization state of macrophages plays a crucial role in diabetic wound healing, with normal wounds transitioning to pro-healing M2 macrophages while diabetic wounds continue to exhibit pro-inflammatory M1 macrophage polarization. Targeting factors that promote M2 macrophage polarization and treatments aimed at reducing hyperglycemia and pro-inflammatory cytokines may be key in improving diabetic wound healing outcomes.

TRANSLATIONAL RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Profiles of Innate Immune Cell Infiltration and Related Core Genes in Psoriasis

Xiaoting Gong et al.

Summary: This study utilized the CIBERSORT algorithm to identify the infiltration of innate immune cells and related core genes in psoriatic plaques, revealing significant differences in the innate immune cell composition between psoriatic skin and control skin. The study also found that certain genes were associated with disease severity and treatment response, providing novel insights for clinical decision-making and mechanism study in psoriasis.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Pharmacology & Pharmacy

Gastroprotective Effects of Periplaneta americana L. Extract Against Ethanol-Induced Gastric Ulcer in Mice by Suppressing Apoptosis-Related Pathways

Shu Fu et al.

Summary: Experimental results showed that the 20% ethanol extract of Periplaneta americana L. exerted gastroprotective effects by protecting gastric mucosa, suppressing inflammatory cytokines, and downregulating the MyD88/NF-κB pathway.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

Macrophage Polarization and Its Role in Liver Disease

Cheng Wang et al.

Summary: Macrophages play a crucial role in liver diseases, with their polarization being significantly important in the initiation and progression of liver diseases. Macrophage polarization involves various molecular mechanisms, including multiple signaling pathways. Further research on macrophage polarization is essential for understanding and treating liver diseases effectively.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Peripheral cells from patients with systemic sclerosis disease co-expressing M1 and M2 monocyte/macrophage surface markers: Relation to the degree of skin involvement

Mona Embarek Mohamed et al.

Summary: The monocyte/macrophage lineage cells play a role in the pathogenesis of systemic sclerosis (SSc) disease. Different cell phenotypes within this lineage were identified in peripheral blood of SSc patients, and they were significantly associated with clinical findings.Cells with M1, M2, and mixed M1/M2 phenotypes were higher in SSc patients, and some were associated with specific clinical manifestations like pitting scars, arthritis, and myalgia.

HUMAN IMMUNOLOGY (2021)

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Article Chemistry, Medicinal

Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma

Gyu-Tae Park et al.

Summary: The study demonstrates that Echinochrome A treatment can alleviate bleomycin-induced scleroderma by normalizing dermal thickness and suppressing collagen deposition, reducing the number of activated myofibroblasts and macrophages in the affected skin, and decreasing serum levels of inflammatory cytokines. EchA shows promise for treating scleroderma by exerting anti-fibrosis and anti-inflammatory effects.

MARINE DRUGS (2021)

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Article Biochemistry & Molecular Biology

Periplaneta americana Oligosaccharides Exert Anti-Inflammatory Activity through Immunoregulation and Modulation of Gut Microbiota in Acute Colitis Mice Model

Kaimin Lu et al.

Summary: The study found that oligosaccharides from Periplaneta americana have potent antioxidant activities, significantly alleviate the symptoms of colitis, and protect the integrity of the intestines. OPA exhibited anti-inflammatory activity by regulating Th1/Th2, reducing oxidative stress, preserving intestinal barrier integrity, and increasing microbial diversity to protect the gut.

MOLECULES (2021)

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Article Food Science & Technology

The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer

Lin Zhou et al.

Summary: The study found that the main active components of chenpi (nobiletin, naringenin, hesperetin) regulate five core targets (AKT1, TP53, IL6, VEGFA, MMP9), can prevent COPD and its progression to lung cancer by being involved in the PI3K-Akt signaling pathway and MAPK signaling pathway. Molecular docking indicated that hesperetin had better binding activity for core targets. In mouse lung cancer with COPD, treatment with hesperetin dose-dependently improved lung tissue injury in COPD, suppressed the protein expression of AKT1, IL6, VEGFA, MMP9, and up-regulated the protein expression of TP53.

FOOD & NUTRITION RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Immunology of Acute and Chronic Wound Healing

Kamila Raziyeva et al.

Summary: Skin wounds significantly impact the global healthcare system, with acute and chronic wounds being the two main types. The immune response is crucial for acute wound healing, but dysregulation can lead to chronic wounds characterized by persistent inflammation and delayed healing. Current research focuses on immunomodulatory therapeutic strategies to improve wound healing, targeting factors such as macrophage phenotype and inflammatory mediators.

BIOMOLECULES (2021)

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Article Immunology

Lycopus lucidus Turcz Exerts Neuroprotective Effects Against H2O2-Induced Neuroinflammation by Inhibiting NLRP3 Inflammasome Activation in Cortical Neurons

Hyunseong Kim et al.

Summary: LLT effectively protected cultured rat cortical neurons from H2O2-induced neuronal injury by inhibiting NLRP3 inflammasome activation. Specifically, it reduced caspase-1 activation and regulated the secretion of IL-1 beta/IL-18, enhancing axonal elongation and synaptic connectivity in rat primary cortical neurons. This study demonstrates the potential of LLT as a promising therapeutic for neurological diseases by suppressing inflammation and promoting neuroprotection and neuron repair.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Review Cell Biology

Metabolic orchestration of the wound healing response

Sabine A. Eming et al.

Summary: Macrophages play a central role in wound healing, with inflammatory macrophages responding to initial wound stimuli and alternatively activated macrophages essential for wound closure. Metabolic changes in macrophages have significant effects on their functional states, and the metabolic interplay between macrophages and fibroblasts is crucial for wound healing.

CELL METABOLISM (2021)

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Review Rheumatology

Contribution of monocytes and macrophages to the pathogenesis of systemic sclerosis: recent insights and therapeutic implications

Alain Lescoat et al.

Summary: Recent studies have highlighted the critical role of monocytes and macrophages in the pathogenesis of systemic sclerosis (SSc), showing increased monocyte adhesion and the presence of new macrophage subpopulations. Impaired pro-resolving capacities of macrophages may also contribute to the inflammatory and autoimmune features of SSc, making macrophages a potential target for therapeutic interventions. Investigative drugs targeting macrophage polarization have shown promising results in preclinical models and clinical trials, suggesting a potential novel approach for the treatment of SSc and other fibro-inflammatory disorders.

CURRENT OPINION IN RHEUMATOLOGY (2021)

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Review Dermatology

Multiple roles of macrophage in skin

Kozo Nakai

Summary: Research on macrophages has revealed a significant diversity in classification and function, especially in the field of cardiology. However, studies in the field of dermatology are still relatively lacking.

JOURNAL OF DERMATOLOGICAL SCIENCE (2021)

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Article Plant Sciences

Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation

Jie Cheng et al.

Summary: The study demonstrated that paeoniflorin exhibits neuroprotective and antidepressant effects in mice by activating neuronal FGF-2/FGFR1 signaling pathway and inhibiting microglial activation in the hippocampus, suggesting its potential therapeutic application for depression.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Chemistry, Medicinal

Multifaceted Clinical Effects of Echinochrome

Hyoung Kyu Kim et al.

Summary: Histochrome is a natural antioxidant with echinochrome A as its active substance, which has been found effective in various disease models without adverse effects. It is used in cardiology and ophthalmology, blocking various links of free radical reactions simultaneously.

MARINE DRUGS (2021)

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Review Chemistry, Medicinal

The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases

Thomas Efferth et al.

Summary: Artemisinin and its derivatives exhibit immunosuppressive activity by inhibiting various receptor-coupled signaling pathways, leading to the inhibition of the transcription factor NF-kappa B. They downregulate numerous downstream genes involved in immune cell differentiation, apoptosis, proliferation, signal transduction, and antioxidant stress response. Additionally, artemisinins have shown therapeutic efficacy in various inflammatory and autoimmune diseases in disease-relevant animal models.

MEDICINAL RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways

Si-Min Zhang et al.

Summary: Our research showed for the first time that M2 promotes wound healing by secreting CTGF, which further mediates the proliferation and migration of fibroblasts via the AKT, ERK1/2, and STAT3 pathways.

MOLECULAR BIOLOGY REPORTS (2021)

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Review Rheumatology

Advances in epigenetics in systemic sclerosis: molecular mechanisms and therapeutic potential

Pei-Suen Tsou et al.

Summary: Systemic sclerosis (SSc) is a complex inflammatory fibrotic disease with unknown etiology and partially understood pathogenesis, carrying the highest mortality rate among rheumatic diseases. Epigenetic aberrations play a crucial role in SSc pathogenesis, affecting immune cells, endothelial cells, and fibroblasts, presenting potential new avenues for therapeutic interventions.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Pharmacology & Pharmacy

A multi-herb-combined remedy to overcome hyper-inflammatory response by reprogramming transcription factor profile and shaping monocyte subsets

Gejing De et al.

Summary: The water extract solution of Huang-Lian-Jie-Du decoction (WEH) attenuated inflammatory responses, rearranged the acute myelopoiesis related transcriptional factor profile, and protected mice from lethal septic shock by blocking multiple signaling pathways. Mixing the nine principal ingredients of WEH reproduced the protective effect, and reducing compounds within a multi-herb water extract to a seven-chemical combination exhibited superior therapeutic efficacy compared with WEH.

PHARMACOLOGICAL RESEARCH (2021)

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Review Pharmacology & Pharmacy

Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review

Zahra Memariani et al.

Summary: Cancer rates are increasing in many low- and middle-income countries due to various factors, including lifestyle changes and societal problems. Different treatment approaches like chemotherapy, surgery, and radiation therapy are used, but can have various short- and long-term side effects. Recent studies show that compounds like naringin and naringenin from citrus fruits have anti-cancer properties through different signaling pathways, and when combined with current anti-cancer agents, can show synergistic effects and help overcome multidrug resistance in cancer treatment.

PHARMACOLOGICAL RESEARCH (2021)

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Review Nutrition & Dietetics

Plant Adaptogens-History and Future Perspectives

Velislava Todorova et al.

Summary: Adaptogens are synthetic compounds or plant extracts that enhance the body's stability against physical loads, with limited clinical trials on humans despite their wide use in the past and present. There is great potential for medicinal products containing adaptogens to be registered for therapeutic purposes in the future.

NUTRIENTS (2021)

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Article Pharmacology & Pharmacy

Angelica Dahurica Regulated the Polarization of Macrophages and Accelerated Wound Healing in Diabetes: A Network Pharmacology Study and In Vivo Experimental Validation

Yonghui Hu et al.

Summary: The study utilized network pharmacology and in vivo validation to investigate how Angelica dahurica promotes faster wound healing in diabetic patients through anti-inflammatory effects, specifically by regulating the polarization of M1 and M2 subtypes of macrophages.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Physiology

Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization

Yinhe Cai et al.

Summary: Huang-Lian-Jie-Du Decoction attenuates atherosclerosis and promotes plaque stability by suppressing M1 polarization and enhancing M2 polarization.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Immunology

Potential Implications of Quercetin in Autoimmune Diseases

Pan Shen et al.

Summary: Autoimmune diseases are a global health problem characterized by immune system breakdown and dysregulation. Quercetin, a natural flavonoid found in fruits, herbs, and vegetables, has beneficial effects such as anti-inflammation, anti-oxidation, and neuroprotection. Studies have indicated that quercetin may have potential preventive and therapeutic effects on autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Transcriptional and Microenvironmental Landscape of Macrophage Transition in Cancer: A Boolean Analysis

Ugo Avila-Ponce de Leon et al.

Summary: The balance between pro- and anti-inflammatory immune responses is crucial in facing complex diseases like cancer. Macrophages play a key role in this balance in the tumor microenvironment, where cancer cells can evade attack by manipulating macrophages. Despite this, the M1 phenotype still exists and has the ability to eliminate tumor cells. The study used a Boolean modeling approach to understand how the tumor microenvironment influences macrophage behavior and found new hybrid cell populations that were previously undescribed.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Guya D. Marconi et al.

Summary: The epithelial-mesenchymal transition (EMT) is a crucial event in cell development, playing key roles in wound healing and organ fibrosis. EMT is classified into three types: type-1 EMT, type-2 EMT, and type-3 EMT, each with specific functions in embryogenesis, wound healing, and cancer progression respectively.

CELLS (2021)

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Review Respiratory System

Pulmonary hypertension phenotypes in patients with systemic sclerosis

Ashraful Haque et al.

Summary: Pulmonary hypertension commonly occurs in patients with systemic sclerosis and is associated with significant morbidity and increased mortality. Different forms of PH associated with SSc require accurate and early diagnosis for optimal treatment. Recent changes to diagnostic criteria have resulted in therapeutic uncertainty for patients with borderline pulmonary hemodynamics.

EUROPEAN RESPIRATORY REVIEW (2021)

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Review Integrative & Complementary Medicine

Therapeutic Effects of Shikonin on Skin Diseases: A Review

Zhenzhen Mu et al.

Summary: Shikonin, extracted from the dried root of Zicao, is a primary active component in traditional Chinese herbal medicine. It exhibits anti-proliferative, anti-inflammatory, and anti-angiogenic activities, as well as triggers reactive oxygen species production, suppresses exosome release, and induces apoptosis. Shikonin shows protective effects against skin diseases like psoriasis, melanoma, and hypertrophic scars, making it a potential candidate for new drug development.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

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Article Integrative & Complementary Medicine

Angelica dahurica and Rheum officinale Facilitated Diabetic Wound Healing by Elevating Vascular Endothelial Growth Factor

Yuh-Huey Chao et al.

Summary: The study indicated that treatment with Angelica dahurica and Rheum officinale could enhance wound healing in diabetic rats by altering the healing pattern toward that of nondiabetic rats.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Platelet-rich plasma regulating the repair of ultraviolet B-induced acute tissue inflammation: adjusting macrophage polarization through the activin receptor-follistatin system

Gajin Park et al.

Summary: The study shows that PRP can alleviate acute skin tissue inflammation induced by UVB and promote collagen proliferation. PRP regulates macrophage polarization to reduce inflammation and stimulate collagen regeneration.

BIOENGINEERED (2021)

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Review Materials Science, Biomaterials

Anti-inflammation biomaterial platforms for chronic wound healing

Zejun Xu et al.

Summary: With the increasing number of chronic wounds, the inflammatory stage has been identified as the rate-limiting stage of healing. Anti-inflammatory strategies have shown effectiveness in increasing the healing rate, and biomaterial platforms based on these strategies are emerging as potential therapies for accelerating chronic wound repair.

BIOMATERIALS SCIENCE (2021)

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Article Plant Sciences

Naoxintong accelerates diabetic wound healing by attenuating inflammatory response

Leyu Fang et al.

Summary: The study demonstrated that NXT can accelerate diabetic wound healing and alleviate inflammatory response, providing important evidence for the use of NXT in the treatment of chronic diabetic wound healing.

PHARMACEUTICAL BIOLOGY (2021)

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Article Mathematical & Computational Biology

Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.)

Mohammed Saleh Al Aboody

Summary: Celery, a common edible herb used in traditional medicine, has been proven to possess antioxidant, antimicrobial, and cytotoxic properties. The study showed significant antioxidant activity, potential inhibition against various strains, and greater cytotoxic effects against cancer cell lines.

BIOINFORMATION (2021)

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Review Chemistry, Medicinal

Plants Used as Antihypertensive

Tarawanti Verma et al.

Summary: Hypertension is a critical health problem that can lead to other cardiovascular diseases, and herbal medicines have been widely used for managing and treating it with minimal side effects. These herbs have anti-hypertensive effects and help the body combat various health issues.

NATURAL PRODUCTS AND BIOPROSPECTING (2021)

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Article Plant Sciences

Evaluation of the anti-inflammatory and antioxidant pharmcodynamic compoents of naoxintong capsules as a basis of broad spectrum effects

Bin Lv et al.

Summary: The study found that NXT could significantly inhibit the expression of NF-kappa B, MMP-9, and NO in cells, and six components of NXT were identified that can simultaneously inhibit these factors while exerting cytoprotective effects by interacting with the PI3K/AKT pathway. These findings suggest that the ingredients in NXT have therapeutic potential and could be a basis for future research and application.

PHARMACEUTICAL BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Histamine up-regulates oncostatin M expression in human M1 macrophages

Susanne Mommert et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Article Rheumatology

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

Brian Skaug et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Pharmacology & Pharmacy

Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice

Qinyu Wang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation

Ting He et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Hematology

Macrophages in Atherosclerosis Regression

Tessa J. Barrett

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages

Tangxiele Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms

Tienthanh Nguyen et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Surgery

Quercetin Promotes Diabetic Wound Healing via Switching Macrophages From M1 to M2 Polarization

Jia Fu et al.

JOURNAL OF SURGICAL RESEARCH (2020)

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Article Medicine, Research & Experimental

PSORI-CM02 formula alleviates imiquimod-induced psoriasis via affecting macrophage infiltration and polarization

Leng Li et al.

LIFE SCIENCES (2020)

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Review Pharmacology & Pharmacy

Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony

Lingling Zhang et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Plant Sciences

A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages

Lu Jin et al.

PHYTOMEDICINE (2020)

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Review Cell Biology

Biomarkers, oxidative stress and autophagy in skin aging

Yanpei Gu et al.

AGEING RESEARCH REVIEWS (2020)

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Review Immunology

Macrophage: A Potential Target on Cartilage Regeneration

Tiago Lazzaretti Fernandes et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Role of microRNA-21 and Its Underlying Mechanisms in Inflammatory Responses in Diabetic Wounds

Cole Liechty et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Medicine, General & Internal

Pathophysiology, Clinical Presentation, and Treatment of Psoriasis A Review

April W. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, Research & Experimental

TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis

Clara Dees et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Biochemistry & Molecular Biology

Anti-atopic dermatitis effects of hydrolyzed celery extract in mice

Denis Nchang Che et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

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Article Medicine, Research & Experimental

Knockout of E2F1 enhances the polarization of M2 phenotype macrophages to accelerate the wound healing process

Hui Xiao et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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Article Multidisciplinary Sciences

Deciphering human macrophage development at single-cell resolution

Zhilei Bian et al.

NATURE (2020)

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Article Pharmacology & Pharmacy

Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease

Alain Lescoat et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Dermatology

Anti-psoriatic properties of paeoniflorin: suppression of the NF-kappaB pathway and keratin 17

Xiaocui Bai et al.

EUROPEAN JOURNAL OF DERMATOLOGY (2020)

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Article Cell Biology

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Jing Zhang et al.

CELL METABOLISM (2020)

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Article Pharmacology & Pharmacy

Periplaneta americanaExtracts Accelerate Liver Regenerationviaa Complex Network of Pathways

Yingying Zou et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Immunology

Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis

Huiling Peng et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

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Review Pharmacology & Pharmacy

Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)

Yu-Feng Huang et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Pharmacology & Pharmacy

The birth of artemisinin

Nan Ma et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Cell & Tissue Engineering

Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Wei Liu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell Biology

Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation

Luting Zeng et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Chemistry, Multidisciplinary

Chronic wounds: Current status, available strategies and emerging therapeutic solutions

Kevin Las Heras et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Oncology

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

Senlin Zhao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Immunology

The Roles of Inflammation in Keloid and Hypertrophic Scars

Zheng-Cai Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Diosmetin and Its Glycoside, Diosmin, Improve Atopic Dermatitis-Like Lesions in 2,4-Dinitrochlorobenzene-Induced Murine Models

Sang-a Park et al.

BIOMOLECULES & THERAPEUTICS (2020)

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Article Biochemistry & Molecular Biology

Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1α/PDGF-β signaling pathway

Jun Guo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Plant Sciences

Rosehip Oil Promotes Excisional Wound Healing by Accelerating the Phenotypic Transition of Macrophages

Zhiyong Lei et al.

PLANTA MEDICA (2019)

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Article Medicine, Research & Experimental

PSORI-CM02 alleviates IMQ-induced mouse dermatitis via differentially regulating pro- and anti-inflammatory cytokines targeting of Th2 specific transcript factor GATA3

Ding-hong Wu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Dong Xu et al.

MOLECULES (2019)

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Review Pharmacology & Pharmacy

The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule

Jihong Han et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Medical Laboratory Technology

Targeting epigenetic mechanisms in diabetic wound healing

Aaron Den Dekker et al.

TRANSLATIONAL RESEARCH (2019)

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Review Pharmacology & Pharmacy

The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

Jiajie Tu et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Immunology

Pathophysiology of systemic sclerosis: current understanding and new insights

Maurizio Cutolo et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Strategy for hypertrophic scar therapy: Improved delivery of triamcinolone acetonide using mechanically robust tip-concentrated dissolving microneedle array

Shiqi Lin et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Medicine, Research & Experimental

Periplaneta Americana L. as a novel therapeutics accelerates wound repair and regeneration

Long-Jian Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Infectious Diseases

Metabolic immunomodulation of macrophage functional plasticity in nonhealing wounds

Catherine B. Anders et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2019)

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Article Clinical Neurology

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

Natalia Kolosowska et al.

NEUROTHERAPEUTICS (2019)

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Article Biotechnology & Applied Microbiology

The protective effects of lycopus lucidus turcz in diabetic retinopathy and its possible mechanisms

Jinlu Liu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Pathology

Diversity, Mechanisms, and Significance of Macrophage Plasticity

Massimo Locati et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

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Article Medicine, Research & Experimental

Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea

Xin Yuan et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Medicine, Research & Experimental

Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer

Jawun Choi et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation

Jialin Chen et al.

FASEB JOURNAL (2019)

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Article Plant Sciences

Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro

Hui-Jie Fan et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Review Pharmacology & Pharmacy

Pharmacological properties and derivatives of shikonin-A review in recent years

Chuanjie Guo et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Chemistry, Medicinal

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Narges Hedayati et al.

PHYTOTHERAPY RESEARCH (2019)

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Article Immunology

Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction

Kaveh Eghbalzadeh et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Chemistry, Medicinal

Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells

Su-Jeong Oh et al.

MARINE DRUGS (2019)

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Article Allergy

IgG4 drives M2a macrophages to a regulatory M2b-like phenotype: potential implication in immune tolerance

Rodolfo Bianchini et al.

ALLERGY (2019)

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Article Cell Biology

Vitamin D improves sunburns by increasing autophagy in M2 macrophages

Lopa M. Das et al.

AUTOPHAGY (2019)

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Review Cell Biology

M2b macrophage polarization and its roles in diseases

Le-xun Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Article Medicine, Research & Experimental

Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice

Gabriela Adamante et al.

LIFE SCIENCES (2019)

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Article Dermatology

The clinical dynamic changes of macrophage phenotype and function in different stages of human wound healing and hypertrophic scar formation

Lin Chen et al.

INTERNATIONAL WOUND JOURNAL (2019)

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Review Parasitology

Artemisinin Bioactivity and Resistance in Malaria Parasites

Arthur M. Talman et al.

TRENDS IN PARASITOLOGY (2019)

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Review Biochemistry & Molecular Biology

Macrophage polarity in cancer: A review

Masoud Najafi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Rheumatology

DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models

Zongwang Zhang et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Review Immunology

The immunological anatomy of the skin

Kenji Kabashima et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Letter Rheumatology

Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis

Stefano Soldano et al.

ANNALS OF THE RHEUMATIC DISEASES (2018)

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Article Pharmacology & Pharmacy

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

Hong Lu et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Article Dermatology

Rosacea Pathogenesis

Christine S. Ahn et al.

DERMATOLOGIC CLINICS (2018)

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Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Dermatology

Treatment with TNF-α inhibitor rectifies M1 macrophage polarization from blood CD14+monocytes in patients with psoriasis independent of STAT1 and IRF-1 activation

Shang-Hung Lin et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2018)

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Article Plant Sciences

Chemical profiling and the potential active constituents responsible for wound healing in Periploca forrestii Schltr

Lei Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

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Article Cell Biology

IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis

Yuzhu Hou et al.

PROTEIN & CELL (2018)

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Article Pharmacology & Pharmacy

Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+Regulatory T Cells

Chuanjian Lu et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Physiology

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

Paulina Krzyszczyk et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Review Pharmacology & Pharmacy

Naringenin as a potential immunomodulator in therapeutics

Wenfeng Zeng et al.

PHARMACOLOGICAL RESEARCH (2018)

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Article Chemistry, Medicinal

Antiviral and Antioxidant Properties of Echinochrome A

Sergey A. Fedoreyev et al.

MARINE DRUGS (2018)

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Article Cell Biology

Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation

Chih-Hao Lu et al.

MEDIATORS OF INFLAMMATION (2018)

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Article Microbiology

Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation

Mingyi Chen et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Pharmacology & Pharmacy

Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses

Misun Kim et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Leveraging Multilayered Omics Data for Atopic Dermatitis: A Road Map to Precision Medicine

Debajyoti Ghosh et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Food Science & Technology

Protective effect of free phenolics from Lycopus lucidus Turcz. root on carbon tetrachloride-induced liver injury in vivo and in vitro

Yue-Hong Lu et al.

FOOD & NUTRITION RESEARCH (2018)

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Review Biotechnology & Applied Microbiology

Advances in the research of celery, an important Apiaceae vegetable crop

Meng-Yao Li et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2018)

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Article Plant Sciences

Constituents from Apium graveolens and their anti-inflammatory effects

Li-Han Zhu et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2017)

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Review Medicine, General & Internal

Systemic sclerosis

Christopher P. Denton et al.

LANCET (2017)

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Article Medicine, General & Internal

Rosacea

Esther J. van Zuuren

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Hematology

Pathophysiological relevance of macrophage subsets in atherogenesis

Luca Liberale et al.

THROMBOSIS AND HAEMOSTASIS (2017)

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Review Integrative & Complementary Medicine

Anti-tumor effects of the American cockroach, Periplaneta americana

Yanan Zhao et al.

CHINESE MEDICINE (2017)

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Review Immunology

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation

Chao-Yang Lai et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2017)

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Article Multidisciplinary Sciences

IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice

Kozo Nakai et al.

SCIENTIFIC REPORTS (2017)

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Article Medicine, General & Internal

PDTCM: a systems pharmacology platform of traditional Chinese medicine for psoriasis

Dongmei Wang et al.

ANNALS OF MEDICINE (2017)

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Review Biochemistry & Molecular Biology

The JAK/STAT signaling pathway and photobiomodulation in chronic wound healing

Sandy W. Jere et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2017)

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Article Integrative & Complementary Medicine

Bitterness and antibacterial activities of constituents from Evodia rutaecarpa

Xiaoguang Liang et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

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Review Cell Biology

Macrophage polarization: the link between inflammation and related diseases

Samina Bashir et al.

INFLAMMATION RESEARCH (2016)

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Review Oncology

A Breakthrough: Macrophage-Directed Cancer Immunotherapy

Charles D. Mills et al.

CANCER RESEARCH (2016)

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Article Dermatology

Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model

Vengadeshprabhu Karuppagounder et al.

EXPERIMENTAL DERMATOLOGY (2016)

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Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

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Article Plant Sciences

Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment

Yunlong Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Oncology

Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro

Wenqing Cao et al.

BRITISH JOURNAL OF CANCER (2015)

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Article Dermatology

Molecular and Morphological Characterization of Inflammatory Infiltrate in Rosacea Reveals Activation of Th1/Th17 Pathways

Timo Buhl et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Article Oncology

Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin

Cheng Liu

MOLECULAR MEDICINE REPORTS (2015)

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Article Engineering, Biomedical

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

Kara L. Spiller et al.

BIOMATERIALS (2014)

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Article Immunology

Serum from patients with systemic vasculitis induces alternatively activated macrophage M2c polarization

Susanne M. Ohlsson et al.

CLINICAL IMMUNOLOGY (2014)

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Review Immunology

Macrophage phenotypes in atherosclerosis

Sophie Colin et al.

IMMUNOLOGICAL REVIEWS (2014)

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Article Rheumatology

Derivation and Validation of a Prediction Rule for Two-Year Mortality in Early Diffuse Cutaneous Systemic Sclerosis

Robyn T. Domsic et al.

ARTHRITIS & RHEUMATOLOGY (2014)

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Review Immunology

Molecular mechanisms that influence the macrophage M1-M2 polarization balance

Nan Wang et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Hematology

Tumor-Associated Macrophages as a Paradigm of Macrophage Plasticity, Diversity, and Polarization: Lessons and Open Questions

Alberto Mantovani et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Review Immunology

Macrophages in skin injury and repair

Babak Mahdavian Delavary et al.

IMMUNOBIOLOGY (2011)

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Article Neurosciences

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

Sarah R. Wilson et al.

NATURE NEUROSCIENCE (2011)

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Review Immunology

Protective and pathogenic functions of macrophage subsets

Peter J. Murray et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Article Chemistry, Medicinal

Hyaluronidase Inhibitors from Takuran, Lycopus lucidus

Toshihiro Murata et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2010)

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Article Rheumatology

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

Nobuyo Higashi-Kuwata et al.

ARTHRITIS RESEARCH & THERAPY (2010)

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Review Immunology

Skin immune sentinels in health and disease

Frank O. Nestle et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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