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The potential application of encapsulated exosomes: A new approach to increase exosomes therapeutic efficacy

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Nanoscience & Nanotechnology

Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis

Chenggang Zhang et al.

Summary: Circular RNAs (circRNAs)are endogenous noncoding RNAs that play vital roles in many biological processes, particularly in human cancer. Recent studies indicate that circRNAs play an important role in tumor progression through exosomes. However, the specific functions of gastric cancer-derived exosomes and the role of circSTAU2 in gastric cancer (GC) remain largely unknown.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2023)

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Article Biotechnology & Applied Microbiology

Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury

Yohan Han et al.

Summary: The study reveals that CC16 released via small extracellular vesicles (sEVs) has anti-inflammatory activities and protects against ALI. sEV-encapsulated CC16 can activate DNA damage repair pathways and suppress NF-KB signaling by binding to HSP60. Therefore, sEV-CC16 could serve as a potential therapeutic agent for ALI by inhibiting inflammation and DNA damage responses.

MOLECULAR THERAPY (2023)

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Review Anatomy & Morphology

Exosomes and exosome-loaded scaffolds: Characterization and application in modern regenerative medicine

Fatemeh Khazaei et al.

Summary: Exosomes are extracellular vesicles derived from endosomes that have gained attention for their potential use in regenerative therapies and tissue repair. However, their poor bioavailability and lack of controlled-release mechanisms have been addressed by scaffolding them with biomaterials to create Exosomes-loaded scaffolds (ELS). These biomaterial-based scaffolds can be designed and functionalized to improve the bioavailability, biocompatibility, and controlled release of Exosomes.

TISSUE & CELL (2023)

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Review Infectious Diseases

Exosomes: from biology to immunotherapy in infectious diseases

Velia Veronica Rangel-Ramirez et al.

Summary: Exosomes are extracellular vesicles released by various organisms, containing different biomolecules depending on their origin and cellular state. They play a role in cell-cell communication and can have dual effects during infections, both transmitting pathogenic molecules and activating the immune response. Recent omics technologies have allowed for a detailed characterization of exosome content, which may facilitate their therapeutic applications and use in liquid biopsies for diagnosis and prognosis. This review summarizes the current understanding of exosome composition and function in viral, bacterial, fungal, and protozoan infections, and discusses their potential applications for prophylactic and therapeutic purposes.

INFECTIOUS DISEASES (2023)

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Article Medicine, Research & Experimental

Exosomes released from cisplatin-resistant ovarian cancer cells modulate the reprogramming of cells in tumor microenvironments toward the cancerous cells

Gizem Yilmaz et al.

Summary: Exosomes released from cancer cells are involved in the reorganization of the tumor microenvironment and facilitate the communication between cancer cells and various cell types. The internalization pathway and fate of exosomes released from cisplatin-resistant A2780cis cells have been studied, as well as their effects on recipient cells. Histopathological evaluation and in vivo studies have been conducted to observe the distribution and impact of exosomes. The transfer of oncogenic cargo through exosomes modifies the intracellular signaling of recipient cells and contributes to the initiation and progression of carcinogenesis.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Dermatology

Investigation of miR-126-3p loaded on adipose stem cell-derived exosomes for wound healing of full-thickness skin defects

Jie Ma et al.

Summary: The study found that ADSC-derived exosomal miR-126-3p promotes wound healing of full-thickness skin defects by targeting PIK3R2, increasing collagen deposition and the formation of new blood vessels.

EXPERIMENTAL DERMATOLOGY (2022)

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Review Biochemistry & Molecular Biology

New Promising Therapeutic Avenues of Curcumin in Brain Diseases

Tarek Benameur et al.

Summary: This article introduces the important properties of curcumin in turmeric, including antioxidant, anti-inflammatory, antimicrobial, antiproliferative, antitumor, and anti-aging effects, which show potential in the protection against neurodegenerative diseases. The review also summarizes the bioavailability, mechanism of action, and possible application of curcumin for the prevention or treatment of neurodegenerative disorders.

MOLECULES (2022)

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Article Medicine, Research & Experimental

Exosome-mediated delivery of RBP-J decoy oligodeoxynucleotides ameliorates hepatic fibrosis in mice

Fei He et al.

Summary: This study demonstrates that the infusion of exosomes loaded with RBP-J decoy oligodeoxynucleotides (ODNs) can efficiently inhibit Notch signaling in macrophages and ameliorate hepatic fibrosis in mice, suggesting a promising therapeutic strategy for the treatment of hepatic fibrosis.

THERANOSTICS (2022)

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Article Engineering, Biomedical

HOTAIR-Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing

Louis J. Born et al.

Summary: This study explores the potential of using extracellular vesicles (EVs) for delivery of HOTAIR as a strategy to promote healing of chronic wounds.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1a-me diate d enhancement of angiogenesis

Yaxi Wang et al.

Summary: The study demonstrates the potential therapeutic effect of EVs loaded with VH298 on diabetic wound healing and angiogenesis, as well as the sustained release of VH-EVs through GelMA hydrogel.

ACTA BIOMATERIALIA (2022)

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Article Medicine, Research & Experimental

Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-155 Inhibitor Ameliorate Diabetic Wound Healing

Piyush Gondaliya et al.

Summary: Diabetic wounds are a debilitating complication affecting a significant number of patients, and current therapies are unsatisfactory. This study demonstrates the potential of miR-155 inhibitor-loaded MSC-derived exosomes in promoting diabetic wound healing through synergistic effects. The study also suggests a new approach of using MSC-derived exosomes to encapsulate miRNA and antibiotics for improved management of diabetic wounds.

MOLECULAR PHARMACEUTICS (2022)

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Article Cell & Tissue Engineering

Thermosensitive Hydrogel Loaded with Primary Chondrocyte-Derived Exosomes Promotes Cartilage Repair by Regulating Macrophage Polarization in Osteoarthritis

Xuehan Sang et al.

Summary: A thermosensitive, injectable hydrogel was developed to sustainably release primary chondrocyte-derived exosomes, promoting cartilage repair and regulating macrophage phenotypic transformation, showing potential for OA treatment.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

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Review Oncology

Energy Sources for Exosome Communication in a Cancer Microenvironment

Abhimanyu Thakur et al.

Summary: Exosomal communication in the tumor microenvironment is crucial for cancer development, progression, and metastasis. Exosomes can communicate with neighboring cells or distant organs, promoting tumor growth and cancer progression. Recent studies have identified potential energy sources for exosomes, including mitochondria, adenosine triphosphate, and glycolytic enzymes. This review emphasizes the importance of exosome energy sources and how they maintain structural integrity and stability during communication.

CANCERS (2022)

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Review Oncology

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

Ali Hazrati et al.

Summary: Exosomes are extracellular vesicles produced by cells, playing vital roles in cellular communication. They have paracrine, endocrine, and autocrine effects through interactions with surrounding cells and can regulate gene expression and cytokine production.

BIOMARKER RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Nebulization of extracellular vesicles: A promising small RNA delivery approach for lung diseases

Yohan Han et al.

Summary: sEVs, with a diameter up to 200 nm, can reflect the pathogenesis of human diseases and mediate intercellular communications. This study demonstrates that sEVs can be delivered to murine lungs through a vibrating mesh nebulizer and successfully loaded with small RNAs. Inhalation of siMyd88-loaded sEVs can reduce lipopolysaccharide-induced lung injury in mice.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Cell Biology

MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling

Ren-Jing Hu et al.

Summary: In this study, the researchers investigated the role of ADSC-derived exosomal miR-181a-5p in Klebsiella pneumonia infection-induced lung injury. They found that ADSC-derived exosomal miR-181a-5p could alleviate pulmonary outgrowth and dissemination of K. pneu infection by targeting the STAT3 signaling pathway.

MEDIATORS OF INFLAMMATION (2022)

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Article Medicine, Research & Experimental

Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease

Mohsen Sheykhhasan et al.

Summary: This study investigated the effects of delivering CoQ10 by exosomes derived from adipose-derived stem cells on memory and cognition in a rat model of AD. Results showed that Exo+CoQ10 significantly improved memory impairment and increased BDNF and SOX2 expression compared to CoQ10 and Exo groups alone.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biotechnology & Applied Microbiology

Serpin-loaded extracellular vesicles promote tissue repair in a mouse model of impaired wound healing

Dong Jun Park et al.

Summary: Chronic metabolic diseases such as diabetes is associated with delayed wound healing and dysregulated inflammatory phase of wound repair. This study focuses on the changes in extracellular vesicles (EVs) payload that mediates communication between immune cells and stromal cells in the wound bed, which regulate the rate of wound closure. By transferring EVs from genetically defined mouse models, the functional and molecular basis for differences in the pro-reparative biological activity of diabetic (db/db) vs. wildtype EVs in wound healing is demonstrated. This study establishes a novel therapeutic approach by engineering the payload of EVs, aiming to rescue the Serpin deficiency identified by proteomics and promote wound healing in db/db mice.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Engineered Exosomes for Tumor-Targeted Drug Delivery: A Focus on Genetic and Chemical Functionalization

Ali Akbari et al.

Pharmaceutics (2022)

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Review Cell & Tissue Engineering

The potential use of mesenchymal stem cells and their exosomes in Parkinson's disease treatment

Reza Mosaddeghi Heris et al.

Summary: Parkinson's disease is the second most predominant neurodegenerative disease worldwide, characterized by progressive degeneration of dopaminergic neurons and dopamine depletion leading to severe complications in motor function. Current treatment focuses on symptom relief, highlighting the importance of developing neuroprotective techniques. Regenerative cell therapy, particularly mesenchymal stem cells and their derived exosomes, shows potential effectiveness in treating PD.

STEM CELL RESEARCH & THERAPY (2022)

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Review Medicine, Research & Experimental

New insights on circular RNAs and their potential applications as biomarkers, therapeutic agents, and preventive vaccines in viral infections: with a glance at SARS-CoV-2

Nasim Rahmani-Kukia et al.

Summary: This review provides an overview of circRNAs' biogenesis, function, biomarker and therapeutic potential, and their prospective applications as vaccines against viral infections. CircRNAs, with their stable, abundant, specific, and highly conserved properties, play important roles in modulating immune responses and gene expression.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Review Medicine, Research & Experimental

MicroRNAs in the cancer cell-to-cell communication: An insight into biological vehicles

Behnaz Mansoori et al.

Summary: Cell-to-cell communication networks play crucial roles in coordinating biological processes in cancer cells and altering metabolism in both cancer and non-cancer cells. Extracellular vesicles (EVs), including exosomes and their cargo content such as extracellular circulating miRNAs (ECmiRNAs), have emerged as key mediators of cell-to-cell communication. ECmiRNAs can be taken up by target cells to regulate heterotypic cell interactions and facilitate repression in neighboring cells. EVs-ECmiRNA complexes, together with proteins and lipoprotein structures, may serve as effective mediators between cancer cells.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Medicine, Research & Experimental

CRISPR/Cas9-engineered mesenchymal stromal/stem cells and their extracellular vesicles: A new approach to overcoming cell therapy limitations

Ali Hazrati et al.

Summary: Cell therapy is a novel approach for treating tissue destruction diseases and replacing damaged parts in defective tissues. Mesenchymal stem cells (MSCs) have received significant attention due to their advantages and desirable properties. The secretome derived from MSCs, including growth factors, cytokines, and extracellular vesicles, is utilized for the treatment of various diseases. Gene editing, particularly using CRISPR/Cas9, has been recommended to enhance the therapeutic potential of MSCs by manipulating genes associated with stemness, aging, migration, proliferation, survival, and inflammatory responses.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Pharmacology & Pharmacy

Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis

Asmaa A. Ashour et al.

Summary: Liver fibrosis is a life-threatening disorder with no approved treatment. Luteolin, a plant flavonoid, has potential therapeutic effects in liver fibrosis. However, its poor solubility and metabolism hinder its clinical use. In this study, bone marrow MSCs-derived exosomes were developed as a promising nanocarrier for effective treatment of liver fibrosis.

DRUG DELIVERY (2022)

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Review Medicine, General & Internal

Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

Di Liu et al.

Summary: Sepsis is a common complication of combat injuries and trauma, characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Immunosuppression, one of the major causes of septic death, can be reversed and host resistance can be established by targeting it.

MILITARY MEDICAL RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Exosome-based drug delivery systems and their therapeutic applications

Jaewook Lee et al.

Summary: This review describes the applications and characteristics of exosomes and hybrids of exosomes as drug delivery systems. By describing the processes of drug loading, surface modification, and hybrid synthesis, it reveals the potential and capacity of exosomes as drug carriers.

RSC ADVANCES (2022)

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Article Cell & Tissue Engineering

The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment

Kosar Malekpour et al.

Summary: Musculoskeletal disorders (MSDs) can affect muscles, bones, and joints, with a higher prevalence in the elderly. Multipotent stem cells (MSCs) have been widely studied in regenerative medicine due to their ability to differentiate into various cells and their characteristics such as immunomodulatory properties and production of extracellular vesicles. MSCs and their exosomes play a crucial role in repairing dense connective tissues such as tendons, cartilage, intervertebral discs, bone fractures, and osteoporosis treatment.

STEM CELL REVIEWS AND REPORTS (2022)

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Article Immunology

Salmonella Paratyphi A Outer Membrane Vesicles Displaying Vi Polysaccharide as a Multivalent Vaccine against Enteric Fever

G. Gasperini et al.

Summary: Researchers developed a novel GMMA vaccine through genetic engineering to display specific antigens on bacterial surfaces, inducing a strong antibody response. This vaccine candidate shows potential to provide immune protection against infections caused by different Salmonella serovars.

INFECTION AND IMMUNITY (2021)

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Review Immunology

The immunology of sepsis

Tom van der Poll et al.

Summary: Sepsis is a life-threatening condition caused by infection-induced organ dysfunction, characterized by unbalanced hyperinflammation and immune suppression. Current research aims to stratify sepsis patients into more similar subgroups to better identify those who are likely to benefit from specific immune interventions.

IMMUNITY (2021)

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Article Immunology

Imipenem alters systemic and liver inflammatory responses in CLP- induced sepsis mice in a dose-dependent manner

Arezou Khosrojerdi et al.

Summary: The study demonstrated a dose-dependent effect of imipenem on inflammatory responses in sepsis mice. Treatment with a low dose (25 mg/kg) of imipenem resulted in decreased bacterial load, endotoxin level, and inflammatory cytokine production, improved pathology, and increased survival rate in sepsis mice compared to other groups.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Engineering, Biomedical

The evolution of commercial drug delivery technologies

Ava M. Vargason et al.

Summary: This review article discusses how challenges in delivering small molecules, nucleic acids, peptides, proteins, and cells have led to the development of commercial products and are now guiding the delivery of live-cell therapeutics. Drug delivery technologies have enabled the development of pharmaceutical products that enhance therapeutic delivery, minimize off-target effects, and improve patient compliance. Three drug delivery paradigms have been developed to aid in the successful delivery of small molecules and macromolecules, contributing to the initial clinical success of each therapeutic class.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Microbiology

Acute Infection of Viral Pathogens and Their Innate Immune Escape

Kul Raj Rai et al.

Summary: Viral infections can cause widespread diseases in humans, requiring robust immune responses to prevent potentially fatal acute viral infections. While innate immunity plays a crucial role in viral clearance, it can also contribute to disease progression through immune-mediated host tissue injury.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Neurosciences

Investigating receptor-mediated antibody transcytosis using blood-brain barrier organoid arrays

Claire Simonneau et al.

Summary: Human BBB organoid arrays serve as a robust platform for studying receptor-mediated antibody transcytosis. Through the use of CRISPR/Cas9 gene editing, it was discovered that clathrin is essential for transferrin receptor-dependent transcytosis in BBB organoids. Implementing this platform early in drug discovery can accelerate the development of new brain delivery technologies.

FLUIDS AND BARRIERS OF THE CNS (2021)

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Article Plant Sciences

Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis

Yuan Zhou et al.

Summary: This study developed a novel anti-liver formula LLAAF from XYS, and demonstrated its anti-liver fibrotic activity which may be involved in the regulation of Jak-STAT and PI3K-Akt-FoxO signaling pathways. Network pharmacology combined with transcriptomics analysis was used to identify key compounds and their combinations from XYS, showing synergistic effects on hepatic stellate cell proliferation inhibition. In vitro and in vivo studies confirmed the anti-fibrosis effect of LLAAF in reducing liver fibrosis markers in rats.

PHARMACEUTICAL BIOLOGY (2021)

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Review Medicine, General & Internal

Diabetic Wound-Healing Science

Jamie L. Burgess et al.

Summary: Diabetes mellitus is a chronic metabolic disease characterized by prolonged hyperglycemia that leads to various pathologies, including challenging diabetic wound treatment. Future strategies should target multiple causes of impaired wound healing in diabetic patients due to the increasing prevalence of diabetes.

MEDICINA-LITHUANIA (2021)

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Review Pharmacology & Pharmacy

Deep eutectic solvents for pharmaceutical formulation and drug delivery applications

Shahram Emami et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2020)

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Article Cell Biology

Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer

Mingli Han et al.

CELL DEATH & DISEASE (2020)

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Article Pharmacology & Pharmacy

Cow Milk and Intestinal Epithelial Cell-Derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery

Greta Carobolante et al.

PHARMACEUTICS (2020)

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Article Oncology

Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression

Wei Chen et al.

CANCER LETTERS (2020)

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Article Biotechnology & Applied Microbiology

Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

Barry J. Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer

Qiumo Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Parasitology

Immunogenicity of Exosomes from Dendritic Cells Stimulated with Toxoplasma gondii Lysates in Ocularly Immunized Mice

Bong-Kwang Jung et al.

KOREAN JOURNAL OF PARASITOLOGY (2020)

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Article Medicine, Research & Experimental

Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing

Qijun Lv et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Multidisciplinary Sciences

Exosome-based delivery of super-repressor I kappa B alpha relieves sepsis-associated organ damage and mortality

Hojun Choi et al.

SCIENCE ADVANCES (2020)

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Review Engineering, Biomedical

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

Fatemeh Mehryab et al.

ACTA BIOMATERIALIA (2020)

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Review Medicine, Research & Experimental

Exosomes: Multiple-targeted multifunctional biological nanoparticles in the diagnosis, drug delivery, and imaging of cancer cells

Yuzhong Zheng et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell & Tissue Engineering

miR-19a/19b-loaded exosomes in combination with mesenchymal stem cell transplantation in a preclinical model of myocardial infarction

Shuo Wang et al.

REGENERATIVE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo

Hongyu Tao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Sergey Sedykh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Chemistry, Multidisciplinary

Efficient encapsulation of biocompatible nanoparticles in exosomes for cancer theranostics

Tanziela Tanziela et al.

NANO TODAY (2020)

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Article Medicine, Research & Experimental

Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer

Elnaz Bagheri et al.

LIFE SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Exosome-based immunotherapy: a promising approach for cancer treatment

Zhijie Xu et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

Transferrin and transferrin receptors update

Hiroshi Kawabata

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

Huixin Zhang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Oncology

Milk exosomes - Natural nanoparticles for siRNA delivery

Farrukh Aqil et al.

CANCER LETTERS (2019)

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Article Pharmacology & Pharmacy

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

Ji wei Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques

Soodeh Salarpour et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Oncology

Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells

Catharina Melzer et al.

CANCERS (2019)

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Review Cell Biology

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Benjamin G. Trist et al.

AGING CELL (2019)

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Article Oncology

Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma

Hamideh Monfared et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells

Mengyu Yu et al.

CANCER SCIENCE (2019)

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Article Nanoscience & Nanotechnology

A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

Hongxiang Wei et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using Layer-by-Layer Nanoparticles

Ki Young Choi et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Medicine, Research & Experimental

Exosomes from M1-Polarized Macrophages Enhance Paclitaxel Antitumor Activity by Activating Macrophages-Mediated Inflammation

Piaopiao Wang et al.

THERANOSTICS (2019)

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Article Cell Biology

Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication

Yuag-Meng Liu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

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Article Biochemical Research Methods

An Exosome-Based Vaccine Platform Imparts Cytotoxic T Lymphocyte Immunity Against Viral Antigens

Simona Anticoli et al.

BIOTECHNOLOGY JOURNAL (2018)

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Article Gastroenterology & Hepatology

Exosome miR-335 as a novel therapeutic strategy in hepatocellular carcinoma

Fang Wang et al.

HEPATOLOGY (2018)

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Article Biotechnology & Applied Microbiology

miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner

Lei Wang et al.

MOLECULAR THERAPY (2018)

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Article Nanoscience & Nanotechnology

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

Yan Li et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Article Dentistry, Oral Surgery & Medicine

Clinical factors affecting salivary transferrin level, a marker of blood contamination in salivary analysis

Jeong-Hyun Kang et al.

BMC ORAL HEALTH (2018)

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Article Biochemical Research Methods

An Exosome-Based Vaccine Platform Imparts Cytotoxic T Lymphocyte Immunity Against Viral Antigens

Simona Anticoli et al.

BIOTECHNOLOGY JOURNAL (2018)

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Article Chemistry, Multidisciplinary

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

Mengke Qu et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Biochemistry & Molecular Biology

DNA Vectors Generating Engineered Exosomes Potential CTL Vaccine Candidates Against AIDS, Hepatitis B, and Tumors

Flavia Ferrantelli et al.

MOLECULAR BIOTECHNOLOGY (2018)

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Article Pharmacology & Pharmacy

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

Senthilkumar Kalimuthu et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Nanoscience & Nanotechnology

Exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus

Xiaohong Yang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Biochemistry & Molecular Biology

Efficient Delivery of Tyrosinase Related Protein-2 (TRP2) Peptides to Lymph Nodes using Serum-Derived Exosomes

Ok Park et al.

MACROMOLECULAR BIOSCIENCE (2018)

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Review Biotechnology & Applied Microbiology

Recent advancements in the use of exosomes as drug delivery systems

Edwin J. Bunggulawa et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Review Biochemistry & Molecular Biology

Insights into circular RNA biology

Karoline K. Ebbesen et al.

RNA BIOLOGY (2017)

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Review Oncology

The molecular mechanisms of chemoresistance in cancers

Hua-Chuan Zheng

ONCOTARGET (2017)

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Article Medicine, Research & Experimental

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

Jialei Yang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

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Article Pharmacology & Pharmacy

Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin

Farrukh Aqil et al.

AAPS JOURNAL (2017)

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Article Biochemistry & Molecular Biology

Atorvastatin augments temozolomide's efficacy in glioblastoma via prenylation-dependent inhibition of Ras signaling

Peng Peng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Cell & Tissue Engineering

RECENT ADVANCES IN HYDROGELS FOR CARTILAGE TISSUE ENGINEERING

S. L. Vega et al.

EUROPEAN CELLS & MATERIALS (2017)

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Article Engineering, Biomedical

Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis

Eunee Koh et al.

BIOMATERIALS (2017)

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Article Medicine, Research & Experimental

Apoptotic effect of atorvastatin in glioblastoma spheroids tumor cultured in fibrin gel

Neda Bayat et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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Article Cell & Tissue Engineering

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

Tek N. Lamichhane et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2016)

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Article Biotechnology & Applied Microbiology

Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

Mohamad Hadla et al.

NANOMEDICINE (2016)

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Article Nanoscience & Nanotechnology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Review Nanoscience & Nanotechnology

Development and regulation of exosome-based therapy products

Elena V. Batrakova et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2016)

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Review Microbiology

Immune Escape Strategies of Malaria Parasites

Pollyanna S. Gomes et al.

FRONTIERS IN MICROBIOLOGY (2016)

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Article Oncology

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance

Bridget T. Kreger et al.

CANCERS (2016)

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Article Biochemistry & Molecular Biology

Myocardial Infarction: Symptoms and Treatments

Lei Lu et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2015)

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Review Chemistry, Multidisciplinary

Exosome mediated communication within the tumor microenvironment

Lara Milane et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

Heikki Saari et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Oncology

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Guohua Lou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

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Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

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Review Biochemistry & Molecular Biology

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

Yan He et al.

MOLECULES (2015)

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Article Virology

HPV-E7 Delivered by Engineered Exosomes Elicits a Protective CD8(+) T Cell-Mediated Immune Response

Paola Di Bonito et al.

VIRUSES-BASEL (2015)

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Review Neurosciences

Mechanisms and Functional Significance of Stroke-Induced Neurogenesis

Quentin Marlier et al.

FRONTIERS IN NEUROSCIENCE (2015)

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Article Chemistry, Multidisciplinary

Bacterial Protoplast-Derived Nanovesicles as Vaccine Delivery System against Bacterial Infection

Oh Youn Kim et al.

NANO LETTERS (2015)

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Review Pharmacology & Pharmacy

Liposomal siRNA nanocarriers for cancer therapy

Bulent Ozpolat et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

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Article Engineering, Biomedical

Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis

Pengfei Xu et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Yanhua Tian et al.

BIOMATERIALS (2014)

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Article Nanoscience & Nanotechnology

Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages

Fatemeh Momen-Heravi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Article Cell Biology

Enhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated delivery of the Survivin-T34A mutant

Jonathan R. Aspe et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Article Oncology

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

Mark Katakowski et al.

CANCER LETTERS (2013)

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Article Biotechnology & Applied Microbiology

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Shin-ichiro Ohno et al.

MOLECULAR THERAPY (2013)

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Article Multidisciplinary Sciences

Inhibition of Proliferation and Induction of Autophagy by Atorvastatin in PC3 Prostate Cancer Cells Correlate with Downregulation of Bcl2 and Upregulation of miR-182 and p21

Xinjian Peng et al.

PLOS ONE (2013)

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Review Oncology

Mechanisms of chemoresistance in cancer stem cells

Lissa Nurrul Abdullah et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2013)

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Article Immunology

Novel CD8+ T cell-based vaccine stimulates Gp120-specific CTL responses leading to therapeutic and long-term immunity in transgenic HLA-A2 mice

Roopa Hebbandi Nanjundappa et al.

VACCINE (2012)

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Article Biotechnology & Applied Microbiology

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Xiaoying Zhuang et al.

MOLECULAR THERAPY (2011)

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Article Multidisciplinary Sciences

Exosomes from Plasmodium yoelii-Infected Reticulocytes Protect Mice from Lethal Infections

Lorena Martin-Jaular et al.

PLOS ONE (2011)

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Article Cell & Tissue Engineering

One-step generation of murine embryonic stem cell-derived mesoderm progenitors and chondrocytes in a serum-free monolayer differentiation system

Elaine Y. L. Waese et al.

STEM CELL RESEARCH (2011)

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Article Immunology

GP120-specific exosome-targeted T cell-based vaccine capable of stimulating DC- and CD4+ T-independent CTL responses

Roopa Hebbandi Nanjundappa et al.

VACCINE (2011)

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Article Immunology

Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming

Dong Ho Lee et al.

VACCINE (2011)

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Article Biotechnology & Applied Microbiology

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Dongmei Sun et al.

MOLECULAR THERAPY (2010)

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Article Biotechnology & Applied Microbiology

The importance of new companies for drug discovery: origins of a decade of new drugs

Robert Kneller

NATURE REVIEWS DRUG DISCOVERY (2010)

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Article Immunology

Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major

Johannes K. Schnitzer et al.

VACCINE (2010)

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Review Dermatology

Cutaneous side effects of anti-tumor necrosis factor biologic therapy: A clinical review

Aikaterini-Evaggelia Moustou et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2009)

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Article Immunology

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

Celine Beauvillain et al.

VACCINE (2009)

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Article Multidisciplinary Sciences

Exosomes Derived from M-Bovis BCG Infected Macrophages Activate Antigen-Specific CD4+ and CD8+ T Cells In Vitro and In Vivo

Pramod K. Giri et al.

PLOS ONE (2008)

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Article Immunology

A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice

Celine Beauvillain et al.

MICROBES AND INFECTION (2007)

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Article Virology

Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies

Seraphin Kuate et al.

VIROLOGY (2007)

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Article Immunology

Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses absence of free antigen

Jesus Colino et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Oncology

Exosomes: A new delivery system for tumor antigens in cancer immunotherapy

JA Cho et al.

INTERNATIONAL JOURNAL OF CANCER (2005)

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Article Oncology

Exosome-based immunotherapy

N Chaput et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2004)

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Review Pharmacology & Pharmacy

Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway

ZM Qian et al.

PHARMACOLOGICAL REVIEWS (2002)

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Article Critical Care Medicine

Definition of sepsis

I Matot et al.

INTENSIVE CARE MEDICINE (2001)

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