Hesperidin ameliorates benign prostatic hyperplasia by attenuating cell proliferation, inflammatory response, and epithelial-mesenchymal transition via the TGF-131/Smad signaling pathway

Article Chemistry, Medicinal

Aescin Protects against Experimental Benign Prostatic Hyperplasia and Preserves Prostate Histomorphology in Rats via Suppression of Inflammatory Cytokines and COX-2

Mohamed Raafat et al.

Summary: The study demonstrates the protective effect of aescin against the development of BPH in rats by suppressing inflammation and proliferation. Further studies should focus on the clinical application of aescin in BPH management.

PHARMACEUTICALS (2022)

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Article Toxicology

In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats

Ebenezer Tunde Olayinka et al.

Summary: This study revealed that finasteride treatment induces testicular toxicity and hesperidin has a protective effect, alleviating oxidative stress and testicular damage caused by finasteride, and possibly inhibiting its binding to 5 alpha-reductase.

TOXICOLOGY MECHANISMS AND METHODS (2021)

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Article

Therapeutic Effects of 25-Hydroxyvitamin D on the Pathological Process of Benign Prostatic Hyperplasia: An In Vitro Evidence

Yanbo Chen et al.

DISEASE MARKERS (2021)

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Article Urology & Nephrology

Relationship Between Chronic Periodontitis and Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia

Hana Hyun et al.

Summary: The study revealed a significant relationship between LUTS/BPH and CP, with patients with CP having higher IPSS scores and lower urine flow rates.

INTERNATIONAL NEUROUROLOGY JOURNAL (2021)

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Article Food Science & Technology

Recovery of hesperidin and narirutin from waste Citrus unshiu peel using subcritical water extraction aided by pulsed electric field treatment

Hee-Jeong Hwang et al.

Summary: This study demonstrated the potential of combining pulsed electric field (PEF) and subcritical water extraction (SWE) for enhancing the extraction of flavonoids from Citrus unshiu peel by-products. The concentrations of hesperidin and narirutin increased with PEF treatment time, and the combination of specific PEF and SWE parameters resulted in the highest extraction yields. PEF treatment increased the amounts of hesperidin and narirutin extracted by 22.1% and 33.6%, respectively.

FOOD SCIENCE AND BIOTECHNOLOGY (2021)

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Article Andrology

LncRNA DIO3OS regulated by TGF-β1 and resveratrol enhances epithelial mesenchymal transition of benign prostatic hyperplasia epithelial cells and proliferation of prostate stromal cells

Yanbo Chen et al.

Summary: DIO3OS is highly expressed in BPH tissues and regulated by TGF-beta 1 and resveratrol. DIO3OS promotes BPH-1 cells EMT and WPMY-1 cells proliferation via miR-656-3p and miR-485-5p.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Article Andrology

Inflammation induced by lipopolysaccharide advanced androgen receptor expression and epithelial-mesenchymal transition progress in prostatitis and prostate cancer

Guang-Chun Wang et al.

Summary: In an inflammatory environment, TNF-alpha, IL-1 beta, IL-6, and TGF-beta were significantly increased in patients with HP and PCa. Both primary prostate epithelial cells and LNCap cells showed increased viability in the presence of 10μg/mL LPS, leading to increased AR expression, AR-mediated transcription, and EMT processes. Inhibitors of NF-kappa B, such as BAY11-7082, decreased AR expression and EMT processes, suggesting potential therapeutic value in prostatitis and PCa.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Article Endocrinology & Metabolism

Hesperidin alleviates insulin resistance by improving HG-induced oxidative stress and mitochondrial dysfunction by restoring miR-149

Miao Tian et al.

Summary: The study demonstrated that hesperidin treatment improved oxidative stress and mitochondrial dysfunction induced by high glucose by enhancing antioxidant activities and regulating signaling pathways, potentially through miR-149 expression modulation.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Article Biochemistry & Molecular Biology

Umbelliferone Ameliorates Benign Prostatic Hyperplasia by Inhibiting Cell Proliferation and G1/S Phase Cell Cycle Progression through Regulation of STAT3/E2F1 Axis

Hyo-Jung Kim et al.

Summary: Umbelliferone, derived from coumarin, has been found to exert anti-proliferative effects in BPH-1 cells by modulating the STAT3/E2F1 axis and demonstrating an anti-BPH effect in TP-induced rats by reducing prostate size and inhibiting cell proliferation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Anticancer Activities of Hesperidin via Suppression of Up-Regulated Programmed Death-Ligand 1 Expression in Oral Cancer Cells

Benjawan Wudtiwai et al.

Summary: The study demonstrates that hesperidin effectively reduces cell proliferation and migration of oral cancer cells by inhibiting PD-L1 expression and inactivating STAT1 and STAT3 signaling molecules. This suggests hesperidin could be a potential adjunctive treatment for oral cancer.

MOLECULES (2021)

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Article Cell Biology

Protective Effect of Yi Shen Pai Du Formula against Diabetic Kidney Injury via Inhibition of Oxidative Stress, Inflammation, and Epithelial-to-Mesenchymal Transition in db/db Mice

Qilin Zhang et al.

Summary: YSPDF may ameliorate renal damage in db/db mice through inhibition of oxidative stress, inflammation, and EMT, with the mechanism potentially being related to the activation of the Nrf2 pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Food Science & Technology

Phytosterols in hull-less pumpkin seed oil, rich in Δ7-phytosterols, ameliorate benign prostatic hyperplasia by lowing 5α-reductase and regulating balance between cell proliferation and apoptosis in rats

Xin-cong Kang et al.

Summary: The study revealed that total phytosterol from hull-less pumpkin seed oil, with Delta(7)-phytosterols as its main ingredients, has significant inhibitory effects on BPH. It can improve pathological prostate enlargement, regulate the expression of growth factors, and has the potential for preventing BPH.

FOOD & NUTRITION RESEARCH (2021)

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Article Plant Sciences

Curcumin attenuates prostatic hyperplasia caused by inflammation via up-regulation of bone morphogenetic protein and activin membrane-bound inhibitor

Yuhang Liu et al.

Summary: Curcumin exhibits anti-inflammatory and anti-EMT effects in BPH by targeting the TLR4/BAMBI/TGF-beta 1 signaling pathway, demonstrating its potential utility in the treatment of BPH.

PHARMACEUTICAL BIOLOGY (2021)

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Review Pharmacology & Pharmacy