NaAsO2 regulates TLR4/MyD88/NF-κB signaling pathway through DNMT1/SOCS1 to cause apoptosis and inflammation in hepatic BRL-3A cells

Article Biochemistry & Molecular Biology

Nanosized Titanium Dioxide Induced Apoptosis and Abnormal Expression of Blood-Testis Barrier Junction Proteins Through JNK Signaling Pathway in TM4 Cells

Yaxin Deng et al.

Summary: This study found that nanosized titanium dioxide can induce mitochondria-mediated apoptosis and abnormal expression of BTB junction proteins in TM4 cells by activating the JNK signaling pathway.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

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Article Environmental Sciences

NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway

Shanshan Ran et al.

Summary: The study aimed to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappa B/miR-21/GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer. Results showed that NaAsO2 could lead to mitochondrial apoptosis of cervical cancer cells, with involvement of NF-kappa B and miR-21.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Endocrinology & Metabolism

Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice

Shuiping Liu et al.

Summary: Melatonin (MT) pretreatment alleviates AFB1-induced liver injury by regulating gut microbiota/intestinal FXR/liver TLR4 signaling axis.

JOURNAL OF PINEAL RESEARCH (2022)

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Article Dentistry, Oral Surgery & Medicine

The role of TLR4/MyD88/NF-κB pathway in periodontitis-induced liver inflammation of rats

Yiyun Yue et al.

Summary: This study aimed to clarify the immune mechanism of hepatic injury induced by periodontitis using a rat model. The results showed higher levels of inflammatory response and bone retraction in the periodontitis group, along with elevated levels of immune markers. The study concluded that the TLR4/MyD88/NF-kappa B pathway may play a role in periodontitis-induced liver inflammation in rats.

ORAL DISEASES (2021)

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Article Chemistry, Multidisciplinary

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis

Sai-nan Chen et al.

Summary: This study found that silencing TLR4 attenuates LPS-induced liver injury by inhibiting inflammation and apoptosis, possibly through the TLR4/MyD88/NF-κB signaling pathway. Deletion of TLR4 can mitigate macrophage inflammation and apoptosis, providing hepatoprotection against septic acute liver injury induced by LPS.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Immunology

Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice

Xiaoqi Sun et al.

Summary: The study demonstrated that Baicalin alleviates arsenic trioxide-induced cardiac toxicity by inhibiting oxidative stress, apoptosis, and inflammation, potentially through the inhibition of the TLR4/NF-cB signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Environmental Sciences

Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks

Gaolong Zhong et al.

Summary: Exposure to arsenic trioxide (ATO) can induce intestinal damage, liver inflammation, and pyroptosis in ducks. Changes in intestinal microbiota, increased intestinal permeability, and upregulation of pro-inflammatory cytokines were observed in ATO-exposed ducks. The activation of the LPS/TLR4/NF-kappa B signaling pathway and NLRP3 inflammasome may play a crucial role in ATO-induced hepatotoxicity.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Immunology