4.3 Review

Molecular functions of RNA helicases during ribosomal subunit assembly

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Summary: Ribosomes are ribozymes that require proper folding of rRNAs for catalytic activity. Dbp6, an RNA helicase, plays a role in rRNA folding during ribosome biogenesis. Dbp6 exhibits ATPase, annealing, and clamping activities, which are regulated by ATP, and it interacts with specific rRNA sequences and snoRNAs. These findings suggest that Dbp6's activities are important for proper rRNA folding and snoRNA interactions.

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Summary: Eukaryotic ribosome biogenesis involves the synthesis and stepwise folding of ribosomal RNA (rRNA) into mature ribosomes. The mechanisms of rRNA folding are not well understood, but involve factors such as small nucleolar RNAs (snoRNAs), ribosomal proteins (r-proteins), and ribosome assembly factors. RNA helicases also play a crucial role in ribosome assembly by coordinating RNA folding events and protein release.

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