Interaction of magnetic fields with biogenic magnetic nanoparticles on cell membranes: Physiological consequences for organisms in health and disease

The interaction mechanisms between magnetic fields (MFs) and living systems, which remained hidden for more than a hundred years, continue to attract the attention of researchers from various disciplines: physics, biology, medicine, and life sciences. Revealing these mechanisms at the cellular level would allow to understand complex cell systems and could help to explain and predict cell responses to MFs, intervene in organisms' reactions to MFs of different strengths, directions, and spatial distributions. We suggest several new physical mechanisms of the MF impacts on endothelial and cancer cells by the MF interaction with chains of biogenic and non-biogenic magnetic nanoparticles on cell membranes. The revealed mechanisms can play a hitherto unexpected role in creating physiological responses of organisms to externally applied MFs. We have also a set of theoretical models that can predict how cells will individually and collectively respond to a MF exposure. The physiological se-quences of the MF - cell interactions for organisms in health and disease are discussed. The described effects and their underlying mechanisms are general and should take place in a large family of biological effects of MFs. The results are of great importance for further developing novel approaches in cell biology, cell therapy and medicine.

Automated summary

The interaction mechanisms between magnetic fields and living systems have been a hidden research topic for over a hundred years and have attracted the attention of researchers from various disciplines. Revealing these mechanisms at the cellular level can help understand complex cell systems and predict cell responses to magnetic fields. Several new physical mechanisms of magnetic field impacts on endothelial and cancer cells have been suggested, which can play an unexpected role in creating physiological responses. The results are of great importance for further developing novel approaches in cell biology, cell therapy, and medicine.