4.5 Article

Syndecan-4 regulates the HER2-positive breast cancer cell proliferation cells via CK19/AKT signalling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Syndecan-1 and-4 influence Wnt signaling and cell migration in human breast cancers

Son H. Pham et al.

Summary: This study examined the role of SDC1 and SDC4 in breast cancer using in vitro cell models. The results showed that downregulation of SDC1 and SDC4 decreased the biosynthesis of heparan sulfate modification enzymes and reduced expression of Wnt signaling molecules. Additionally, enhancement/inhibition of HSPGs through heparin/siRNA treatment resulted in increased cell migration. These findings suggest that SDC1/4 have a niche-specific function in the breast cancer microenvironment, mediating Wnt signaling cascades and potentially regulating cell migration.

BIOCHIMIE (2022)

Review Biochemistry & Molecular Biology

Syndecan-4 as a Pathogenesis Factor and Therapeutic Target in Cancer

Jessica Oyie Sousa Onyeisi et al.

Summary: Syndecan-4 plays crucial roles in cell behavior and interactions with growth factors, extracellular matrix molecules, and signaling proteins in various cancers. The expression level of syndecan-4 is important for understanding malignant transformation and it emerges as a target for cancer therapy and diagnosis.

BIOMOLECULES (2021)

Article Multidisciplinary Sciences

Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors

Pooja Sharma et al.

SCIENTIFIC REPORTS (2019)

Review Endocrinology & Metabolism

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression

Arvindhan Nagarajan et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

The role of heparins and nano-heparins as therapeutic tool in breast cancer

Nikos A. Afratis et al.

GLYCOCONJUGATE JOURNAL (2017)

Article Multidisciplinary Sciences

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway

Tomoaki Ohtsuka et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma

Ghazal Heidari-Hamedani et al.

CELLULAR SIGNALLING (2015)

Review Biochemistry & Molecular Biology

Determinants of Glycosaminoglycan (GAG) Structure

Kristian Prydz

BIOMOLECULES (2015)

Article Biochemistry & Molecular Biology

Heparan Sulfate Proteoglycans and Human Breast Cancer Epithelial Cell Tumorigenicity

Rachel K. Okolicsanyi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2014)

Review Oncology

Drug Resistance in Cancer: An Overview

Genevieve Housman et al.

CANCERS (2014)

Article Pathology

Syndecan-1 Overexpression Is Associated With Nonluminal Subtypes and Poor Prognosis in Advanced Breast Cancer

Thuy L. Nguyen et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2013)

Article Multidisciplinary Sciences

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Christina Curtis et al.

NATURE (2012)

Review Oncology

Significance of Heparanase in Cancer and Inflammation

Israel Vlodavsky et al.

CANCER MICROENVIRONMENT (2012)

Review Oncology

HER2-overexpressing breast cancer: time for the cure with less chemotherapy?

Sherene Loi et al.

CURRENT OPINION IN ONCOLOGY (2011)

Article Cell Biology

Syndecan-1 and Syndecan-4 Are Independent Indicators in Breast Carcinoma

Maria E. Lendorf et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2011)

Article Cell Biology

Heparan Sulfate Proteoglycans

Stephane Sarrazin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans

Catherine Kirn-Safran et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Review Oncology

PI3K/Akt signalling pathway and cancer

JAF Vara et al.

CANCER TREATMENT REVIEWS (2004)

Article Biochemistry & Molecular Biology

Hepatocyte growth factor-mediated renal epithelial branching morphogenesis is regulated by glypican-4 expression

A Karihaloo et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Pathology

Prognostic value of proliferation in invasive breast cancer: a review

PJ van Diest et al.

JOURNAL OF CLINICAL PATHOLOGY (2004)