相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Deciphering the mechanism of p73 recognition of p53 response elements using the crystal structure of p73-DNA complexes and computational studies
Tirthankar Koley et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)
Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26
Matteo Burigotto et al.
EMBO JOURNAL (2021)
Role of HSP90 in Cancer
Bereket Birbo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction
Jennifer P. Ditano et al.
SCIENTIFIC REPORTS (2021)
The disruption of protein-protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition
Michael A. Serwetnyk et al.
ACTA PHARMACEUTICA SINICA B (2021)
Intricate Regulatory Mechanisms of the Anaphase-Promoting Complex/Cyclosome and Its Role in Chromatin Regulation
Tatyana Bodrug et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Tumor angiogenesis: causes, consequences, challenges and opportunities
Roberta Lugano et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2020)
Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex
Michal Wieczorek et al.
CELL (2020)
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
Hye-Kyung Park et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Randomized Phase III Study of Ganetespib, a Heat Shock Protein 90 Inhibitor, With Docetaxel Versus Docetaxel in Advanced Non?Small-Cell Lung Cancer (GALAXY-2)
Rathi N. Pillai et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
HSP70 and HSP90 in neurodegenerative diseases
Abha Gupta et al.
NEUROSCIENCE LETTERS (2020)
Fzr/Cdh1 Promotes the Differentiation of Neural Stem Cell Lineages in Drosophila
Phuong Thao Ly et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
Sophie L. Mader et al.
NATURE COMMUNICATIONS (2020)
P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease
Kathleen M. Farmer et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL
Keisuke Izuhara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Samantha Perino et al.
MOLECULAR CANCER THERAPEUTICS (2020)
The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability
Yuan Wu et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2020)
Structure, Function, and Regulation of the Hsp90 Machinery
Maximilian M. Biebl et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)
Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
Sangkyu Park et al.
BIOMOLECULES & THERAPEUTICS (2019)
Hsp70-and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants
Marta Boysen et al.
MOLECULAR CELL (2019)
Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries
Vinay Dahiya et al.
MOLECULAR CELL (2019)
Aggregation of zinc-free p53 is inhibited by Hsp90 but not other chaperones
Huiwen Wu et al.
PROTEIN SCIENCE (2019)
p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway
Claudia Contadini et al.
CELL DEATH & DISEASE (2019)
Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases
Liam Gracia et al.
FRONTIERS IN NEUROSCIENCE (2019)
Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
Shivangee Bansal et al.
CELL DIVISION (2019)
p53 modifications: exquisite decorations of the powerful guardian
Yanqing Liu et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2019)
First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile
Giovanna Speranza et al.
INVESTIGATIONAL NEW DRUGS (2018)
Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53
Huiwen Wu et al.
BIOCHEMISTRY (2018)
The impact of mitotic errors on cell proliferation and tumorigenesis
Michelle S. Levine et al.
GENES & DEVELOPMENT (2018)
The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease
Abdullah Hoter et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle
Steven D. Cappell et al.
NATURE (2018)
TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination
Lorenza Sisinni et al.
JOURNAL OF PATHOLOGY (2017)
The Plasticity of the Hsp90 Co-chaperone System
Priyanka Sahasrabudhe et al.
MOLECULAR CELL (2017)
The HSP90 chaperone machinery
Florian H. Schopf et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site
John D. Huck et al.
CELL REPORTS (2017)
The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
Rachel E. Lackie et al.
FRONTIERS IN NEUROSCIENCE (2017)
The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells
Ionica Masgras et al.
FRONTIERS IN ONCOLOGY (2017)
Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation
Kourtney M. Goode et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia
Jo Ishizawa et al.
BLOOD (2017)
Microtubule-organizing centers: from the centrosome to non-centrosomal sites
Ariana D. Sanchez et al.
CURRENT OPINION IN CELL BIOLOGY (2017)
Mechanisms of Hsp90 regulation
Chrisostomos Prodromou
BIOCHEMICAL JOURNAL (2016)
The HSP90 Molecular Chaperone-An Enigmatic ATPase
Laurence H. Pearl
BIOPOLYMERS (2016)
Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma
Alina Filatova et al.
CANCER RESEARCH (2016)
TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma
Giacomo Lettini et al.
CELL DEATH AND DIFFERENTIATION (2016)
A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer
Anna V. Gaponova et al.
CLINICAL CANCER RESEARCH (2016)
Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1
Sebastian Hoeckner et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
Francesco Meghini et al.
NATURE COMMUNICATIONS (2016)
STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma
Christine M. Heske et al.
ONCOTARGET (2016)
The Mechanism of Hsp90 ATPase Stimulation by Aha1
Annemarie Wolmarans et al.
SCIENTIFIC REPORTS (2016)
Different Relationship between hsp70 mRNA and hsp70 Levels in the Heat Shock Response of Two Salmonids with Dissimilar Temperature Preference
Mario Lewis et al.
FRONTIERS IN PHYSIOLOGY (2016)
Exploring the Functional Complementation between Grp94 and Hsp90
Kevin A. Maharaj et al.
PLOS ONE (2016)
Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds
Elio A. Cino et al.
SCIENTIFIC REPORTS (2016)
Tissue invasion and metastasis: Molecular, biological and clinical perspectives
W. G. Jiang et al.
SEMINARS IN CANCER BIOLOGY (2015)
Hsp90, the concertmaster: tuning transcription
Nidhi Khurana et al.
FRONTIERS IN ONCOLOGY (2015)
TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Valentina Condelli et al.
CANCER RESEARCH (2014)
TAp73 is essential for germ cell adhesion and maturation in testis
Lena Holembowski et al.
JOURNAL OF CELL BIOLOGY (2014)
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a
A. Sparks et al.
ONCOGENE (2014)
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function
Markus Jahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Extracellular Hsp90 Mediates an NF- kBDependent Inflammatory Stromal Program: Implications for the Prostate Tumor Microenvironment
J. E. Bohonowych et al.
PROSTATE (2014)
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
Andrea Rasola et al.
TRENDS IN CELL BIOLOGY (2014)
APC/C is an essential regulator of centrosome clustering
Konstantinos Drosopoulos et al.
NATURE COMMUNICATIONS (2014)
Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop
Sara Alvira et al.
NATURE COMMUNICATIONS (2014)
The Therapeutic Target Hsp90 and Cancer Hallmarks
Yoshihiko Miyata et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Hsp90, an unlikely ally in the war on cancer
Jared J. Barrott et al.
FEBS JOURNAL (2013)
The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma
Manik Chatterjee et al.
HAEMATOLOGICA (2013)
Cep63 and Cep152 Cooperate to Ensure Centriole Duplication
Nicola J. Brown et al.
PLOS ONE (2013)
Evading apoptosis in cancer
Kaleigh Fernald et al.
TRENDS IN CELL BIOLOGY (2013)
The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors
Manuel Eguren et al.
NATURE COMMUNICATIONS (2013)
The Molecular Chaperone Hsp90 Is Required for Cell Cycle Exit in Drosophila melanogaster
Jennifer L. Bandura et al.
PLOS GENETICS (2013)
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum
Michal Marzec et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Evolution and function of diverse Hsp90 homologs and cochaperone proteins
Jill L. Johnson
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification
Suzanna L. Prosser et al.
JOURNAL OF CELL SCIENCE (2012)
The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development
Jefri Heyman et al.
MOLECULAR PLANT (2012)
Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Milena Wiech et al.
PLOS ONE (2012)
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer
Qing Cheng et al.
BREAST CANCER RESEARCH (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer
Eviatar Natan et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Extracellular Heat Shock Protein (Hsp) 70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion
Jessica D. Sims et al.
PLOS ONE (2011)
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine
Pablo C. Echeverria et al.
PLOS ONE (2011)
A single-molecule characterization of p53 search on DNA
Anahita Tafvizi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation
Jessica McCready et al.
BMC CANCER (2010)
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions
Flora Zagouri et al.
BMC CANCER (2010)
The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis
Xiaomin Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The 90-kDa Heat Shock Protein Hsp90 Protects Tubulin against Thermal Denaturation
Felix Weis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1
Jonathan A. Robbins et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function
Mehdi Mollapour et al.
MOLECULAR CELL (2010)
p53-and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress
L. Wiebusch et al.
ONCOGENE (2010)
Targeting HSP90 for cancer therapy
D. Mahalingam et al.
BRITISH JOURNAL OF CANCER (2009)
Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery
Vikram Narayan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas
Leandro C. Cerchietti et al.
NATURE MEDICINE (2009)
Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
D. Walerych et al.
ONCOGENE (2009)
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core
Kian Hoe Khoo et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2009)
BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells
Stella A. Ranuncolo et al.
BLOOD CELLS MOLECULES AND DISEASES (2008)
Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide-binding Pocket
Alison Donnelly et al.
CURRENT MEDICINAL CHEMISTRY (2008)
APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle
Karine Narbonne-Reveau et al.
DEVELOPMENT (2008)
Inhibition of Hsp90 Leads to Cell Cycle Arrest and Apoptosis in Human Malignant Pleural Mesothelioma
Junichi Okamoto et al.
JOURNAL OF THORACIC ONCOLOGY (2008)
A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment
Yuu Kimata et al.
MOLECULAR CELL (2008)
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
Irene Garcia-Higuera et al.
NATURE CELL BIOLOGY (2008)
Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1
K. Sugimoto et al.
ONCOGENE (2008)
The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells
D. Engelbert et al.
ONCOGENE (2008)
Dimerization of Hsp90 is required for in vivo function:: Design and analysis of monomers and dimers
Natalie Wayne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
CHIP chaperones wild type p53 tumor suppressor protein
Veenu Tripathi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The peptide-binding activity of GRP94 is regulated by calcium
Chhanda Biswas et al.
BIOCHEMICAL JOURNAL (2007)
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
Julia W. Pridgeon et al.
PLOS BIOLOGY (2007)
The END network couples spindle pole assembly to inhibition of the anaphase-promoting Complex/Cyclosome in early mitosis
Kenneth H. Ban et al.
DEVELOPMENTAL CELL (2007)
HSP90 cross-links branched actin filaments induced by N-WASP and the Arp2/3 complex
Sun Joo Park et al.
GENES TO CELLS (2007)
The spindle-assembly checkpoint in space and time
Andrea Musacchio et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
High HSP90 expression is associated with decreased survival in breast cancer
Elah Pick et al.
CANCER RESEARCH (2007)
Mitotic regulation of the anaphase-promoting complex
D. J. Baker et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Folding and misfolding mechanisms of the p53 DNA binding domain at physiological temperature
James S. Butler et al.
PROTEIN SCIENCE (2006)
Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc
Kerstin Bellmann et al.
APOPTOSIS (2006)
Mitosis: a matter of getting rid of the right protein at the right time
J Pines
TRENDS IN CELL BIOLOGY (2006)
The anaphase promoting complex/cyclosome: a machine designed to destroy
Jan-Michael Peters
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
rap gene encodes Fizzy-related protein (Fzr) and regulates cell proliferation and pattern formation in the developing Drosophila eye-antennal disc
AC Pimentel et al.
DEVELOPMENTAL BIOLOGY (2005)
The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates
C Kraft et al.
MOLECULAR CELL (2005)
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
T Thompson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner
G de Cárcer
CANCER RESEARCH (2004)
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures
L Müller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hsp90 chaperones wild-type p53 tumor suppressor protein
D Walerych et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles
I Sumara et al.
CURRENT BIOLOGY (2004)
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
A Kamal et al.
NATURE (2003)
The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines
JW Park et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Loss of p53 and centrosome hyperamplification
P Tarapore et al.
ONCOGENE (2002)
A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90 - N-terminal nucleotide binding unmasks a C-terminal binding pocket
C Soti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp9O interactions with wild-type or mutant p53
FW King et al.
EMBO JOURNAL (2001)
Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability
G de Cárcer et al.
EMBO JOURNAL (2001)
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains
C Prodromou et al.
EMBO JOURNAL (2000)
Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
C Scheufler et al.
CELL (2000)
p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: an immunofluorescence study
VB Morris et al.
EXPERIMENTAL CELL RESEARCH (2000)
Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates
BMH Lange et al.
EMBO JOURNAL (2000)