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Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Conformational stability and dynamics of the cancer-associated isoform 133p53 are modulated by p53 peptides and p53-specific DNA
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p73 coordinates with Δ133p53 to promote DNA double-strand break repair
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CELL DEATH AND DIFFERENTIATION (2018)
Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development
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JOURNAL OF PATHOLOGY (2018)
p53 isoforms regulate premature aging in human cells
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ONCOGENE (2018)
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CELL DEATH AND DIFFERENTIATION (2018)
The Transactivation Domains of the p53 Protein
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Mechanisms of DNA Damage, Repair, and Mutagenesis
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ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2017)
Interplay between PTB and miR-1285 at the p53 3′UTR modulates the levels of p53 and its isoform Δ40p53α
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NUCLEIC ACIDS RESEARCH (2017)
Census and evaluation of p53 target genes
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ONCOGENE (2017)
SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/KLF5 pathway
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NATURE COMMUNICATIONS (2017)
Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
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CANCER DISCOVERY (2017)
Δ40p53 is involved in the inactivation of autophagy and contributes to inhibition of cell death in HCT116-Δ40p53 cells
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ONCOTARGET (2017)
The.133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T
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AGING AND DISEASE (2017)
Post-translational regulation of p53 function through 20S proteasome-mediated cleavage
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CELL DEATH AND DIFFERENTIATION (2017)
The emerging role of alternative splicing in senescence and aging
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AGING CELL (2017)
Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
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CELL DEATH AND DIFFERENTIATION (2017)
The presence of the intron 3 16 bp duplication polymorphism of p53 (rs17878362) in breast cancer is associated with a low Δ40p53:p53 ratio and better outcome
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CARCINOGENESIS (2016)
p53 coordinates with Δ133p53 isoform to promote cell survival under low-level oxidative stress
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JOURNAL OF MOLECULAR CELL BIOLOGY (2016)
p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis
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CELL CYCLE (2016)
Cancer-specific mutations in p53 induce the translation of 160p53 promoting tumorigenesis
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EMBO REPORTS (2016)
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FEBS LETTERS (2016)
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p53 Isoforms: Key Regulators of the Cell Fate Decision
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
p53 in the DNA-Damage-Repair Process
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming
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AGING-US (2015)
p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage
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Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis
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WORLD JOURNAL OF GASTROENTEROLOGY (2015)
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The Role of Structural Elements of the 5′-Terminal Region of p53 mRNA in Translation under Stress Conditions Assayed by the Antisense Oligonucleotide Approach
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The relative mRNA expression of p53 isoforms in breast cancer is associated with clinical features and outcome
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Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response
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CELL DEATH AND DIFFERENTIATION (2014)
The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
P53 protein in proliferation, repair and apoptosis of cells
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PROTOPLASMA (2014)
AKT mediates actinomycin D-induced p53 expression
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ONCOTARGET (2014)
IRES mediated translational regulation of p53 isoforms
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WILEY INTERDISCIPLINARY REVIEWS-RNA (2014)
Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
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hnRNP Q regulates translation of p53 in normal and stress conditions
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CELL DEATH AND DIFFERENTIATION (2013)
Ratio disruption of the Δ133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma
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INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
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p53 isoform profiling in glioblastoma and injured brain
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ONCOGENE (2013)
The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression
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ONCOGENE (2013)
Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
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Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity
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CELL DEATH AND DIFFERENTIATION (2012)
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2012)
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Annexin A2 and PSF proteins interact with p53 IRES and regulate translation of p53 mRNA
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CELL (2011)
p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage
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CELL DEATH AND DIFFERENTIATION (2011)
p53 mutant breast cancer patients expressing p53 gamma have as good a prognosis as wild-type p53 breast cancer patients
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Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death
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AGING CELL (2010)
Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript
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FEBS LETTERS (2010)
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GENES & DEVELOPMENT (2010)
Δ40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs
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GENES & DEVELOPMENT (2010)
ΔN133p53 Expression Levels in Relation to Haplotypes of the TP53 Internal Promoter Region
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JOURNAL OF MOLECULAR MEDICINE-JMM (2010)
Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47
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MOLECULAR CELL (2010)
The DNA Damage Response: Making It Safe to Play with Knives
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MOLECULAR CELL (2010)
The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer
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ONCOGENE (2010)
Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer
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ONCOGENE (2010)
Transcriptional Regulation by p53
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair
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JOURNAL OF NUCLEIC ACIDS (2010)
DNA double-strand break repair activities in mammary epithelial cells--influence of endogenous p53 variants
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CARCINOGENESIS (2009)
p53 isoform Δ113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish
Jun Chen et al.
GENES & DEVELOPMENT (2009)
The DNA-damage response in human biology and disease
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NATURE (2009)
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Rosa M. Marion et al.
NATURE (2009)
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
Hyenjong Hong et al.
NATURE (2009)
p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Kaori Fujita et al.
NATURE CELL BIOLOGY (2009)
p53 and little brother p53/47: linking IRES activities with protein functions
R. Grover et al.
ONCOGENE (2009)
Tumour suppression by p53: a role for the DNA damage response?
David W. Meek
NATURE REVIEWS CANCER (2009)
Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47
Darren J. Powell et al.
CELL CYCLE (2008)
Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms
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CELL CYCLE (2008)
Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin
Kelly A. Avery-Kiejda et al.
CLINICAL CANCER RESEARCH (2008)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Yaara Ofir-Rosenfeld et al.
MOLECULAR CELL (2008)
Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment
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MOLECULAR PHARMACOLOGY (2008)
C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
Markus Sauer et al.
NUCLEIC ACIDS RESEARCH (2008)
Noxa: at the tip of the balance between life and death
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ONCOGENE (2008)
microRNAs join the p53 network - another piece in the tumour-suppression puzzle
Lin He et al.
NATURE REVIEWS CANCER (2007)
p53 translational control: A new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics
Marie-Jo Halaby et al.
GENE (2007)
P53 modulation of the DNA damage response
E. Scott Helton et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation
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ONCOGENE (2006)
The identification of an internal ribosomal entry site in the 5′-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage
D. -Q Yang et al.
ONCOGENE (2006)
The p53-Bcl-2 connection
M. T. Hemann et al.
CELL DEATH AND DIFFERENTIATION (2006)
A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia
Nina Anensen et al.
CLINICAL CANCER RESEARCH (2006)
The functional domains in p53 family proteins exhibit both common and distinct properties
K. L. Harms et al.
CELL DEATH AND DIFFERENTIATION (2006)
Two internal ribosome entry sites mediate the translation of p53 isoforms
PS Ray et al.
EMBO REPORTS (2006)
Transcriptional regulation by p53: one protein, many possibilities
O. Laptenko et al.
CELL DEATH AND DIFFERENTIATION (2006)
p53 in recombination and repair
S. A. Gatz et al.
CELL DEATH AND DIFFERENTIATION (2006)
The role of SMG-1 in nonsense-mediated mRNA decay
A Yamashita et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
M Takagi et al.
CELL (2005)
p53 isoforms can regulate p53 transcriptional activity
JC Bourdon et al.
GENES & DEVELOPMENT (2005)
A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint
G Rohaly et al.
CELL (2005)
The p53 pathway: positive and negative feedback loops
SL Harris et al.
ONCOGENE (2005)
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
TM Johnson et al.
NATURE GENETICS (2005)
P53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition
YL Wang et al.
ONCOGENE (2004)
Modulation of mammalian life span by the short isoform of p53
B Maier et al.
GENES & DEVELOPMENT (2004)
Regulation of human p53 activity and cell localization by alternative splicing
A Ghosh et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Manipulation of alternative splicing by a newly developed inhibitor of Clks
M Muraki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ΔN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
S Courtois et al.
ONCOGENE (2002)
DNA substrate dependence of p53-mediated regulation of double-strand break repair
N Akyüz et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53
Q Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
P53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products
YL Yin et al.
NATURE CELL BIOLOGY (2002)
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
A Yamashita et al.
GENES & DEVELOPMENT (2001)
A role for p53 in base excision repair
JM Zhou et al.
EMBO JOURNAL (2001)