4.5 Article

HIPK2 in the physiology of nervous system and its implications in neurological disorders

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

HIPK2 in cancer biology and therapy: Recent findings and future perspectives

Andrea Conte et al.

Summary: Homeodomain-interacting protein kinase 2 (HIPK2) is a versatile enzyme involved in the phosphorylation and regulation of transcriptional regulators and chromatin modifiers. Recent research has shown that HIPK2 has a complex role in cancer, with both tumor suppressive and oncogenic functions depending on the cellular context. This review summarizes the latest data on the involvement of HIPK2 in cancer biology and therapy, highlighting the alterations of this kinase in different cancer types. HIPK2 is emerging as a key player in cancer and could potentially serve as a prognostic marker, a predictor of therapy response, and a therapeutic target.

CELLULAR SIGNALLING (2023)

Review Pharmacology & Pharmacy

Protein kinase inhibitors for amyotrophic lateral sclerosis therapy

Valle Palomo et al.

Summary: ALS is a fatal neurodegenerative disorder with no effective treatment currently available. Multiple pathological mechanisms such as abnormal protein aggregation, neuroinflammation and dysregulation of the ubiquitin proteasome system are involved in the neuropathology of this disease. The lack of reliable animal models has hindered drug development for ALS.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2

Jan Paul Mueller et al.

Summary: HIPK2 expression is auto-regulated by its kinase activity, leading to decreased expression of kinase-dead HIPK2 compared to wild-type HIPK2. This differential expression is dependent on sequences in the C-terminal part of HIPK2 and caused by degradation of nascent kinase-dead HIPK2.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

Article Oncology

Inactivation of homeodomain-interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53-dependent E-cadherin expression

Xueqing Zheng et al.

Summary: This study on oral squamous cell carcinoma (OSCC) revealed that nuclear delocalization of HIPK2 could serve as a negative biomarker for poor prognosis and lymph node metastasis. Depletion of HIPK2 expression promoted OSCC metastasis by suppressing the P53/E-cadherin axis, indicating a potential target for anticancer therapies.

CANCER SCIENCE (2021)

Article Genetics & Heredity

Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model

Stephen D. Kinsey et al.

Summary: HIPKs are a family of conserved proteins essential for vertebrate development, with functional redundancy making it difficult to compare their functions; studying them in fruit flies, where genetic redundancy is reduced, allows for easier functional assessment. The single Hipk present in fruit flies enables rescue experiments with human HIPK genes, providing insights into their individual functions.

G3-GENES GENOMES GENETICS (2021)

Review Clinical Neurology

Rett Syndrome: A Timely Review From Recognition to Current Clinical Approaches and Clinical Study Updates

Autumn S. Ivy et al.

Summary: Since the discovery of the genetic basis of Rett syndrome in 1999, there has been significant growth in our understanding of both the scientific and clinical aspects of the disease. Research has focused on the aberrant MeCP2 protein, genetic factors, and clinical expression of common MECP2 mutations, leading to advancements in treatments for Rett syndrome. As the pathophysiology of the disease becomes better understood, targeted treatments aimed at specific molecular targets will likely continue to improve the quality of life for individuals with Rett syndrome.

SEMINARS IN PEDIATRIC NEUROLOGY (2021)

Article Biochemistry & Molecular Biology

Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice

Davide De Biase et al.

Summary: The loss of HIPK2 in Hipk2-KO mice leads to neuronal loss and morphological alterations in the central nervous system, as well as muscle pathologies in the skeletal and cardiac muscles, suggesting its potential relevance for different aspects of human pathology.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Genetics & Heredity

Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model

Stephen D. Kinsey et al.

Summary: Homeodomain-interacting protein kinases (HIPKs) are essential for vertebrate development, but functional redundancy among the four paralogues makes comparing their functions challenging. By studying them in fruit flies, where genetic redundancy is reduced, researchers were able to gain new insights into the unique and shared functions of HIPKs. This direct comparison in a developmental context revealed potential roles of HIPKs in survival, morphological development, and modulation of key signaling pathways.

G3-GENES GENOMES GENETICS (2021)

Article Neurosciences

Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover

Jiasheng Zhang et al.

JOURNAL OF NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Molecular crosstalk between cancer and neurodegenerative diseases

Jiyeon Seo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Article Multidisciplinary Sciences

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

Kenneth Kin Lam Wong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development

Katrina C. McNeely et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Clinical Neurology

Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Clinical Review

Heather E. Olson et al.

PEDIATRIC NEUROLOGY (2019)

Article Biochemistry & Molecular Biology

Differential intracellular localization and dynamic nucleocytoplasmic em shuttling of homeodomain-interacting protein kinase family members

Olesja Ritter et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Biochemistry & Molecular Biology

The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region

Christopher Agnew et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Clinical Neurology

Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches

Samuel Shribman et al.

LANCET NEUROLOGY (2019)

Article Biochemistry & Molecular Biology

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain

Antonella Scaglione et al.

PROTEIN SCIENCE (2018)

Article Neurosciences

Enteric nervous system manifestations of neurodegenerative disease

Alcmene Chalazonitis et al.

BRAIN RESEARCH (2018)

Article Biochemistry & Molecular Biology

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis

Laura Monteonofrio et al.

ONCOGENE (2018)

Article Clinical Neurology

Lafora Disease: A Review of Molecular Mechanisms and Pathology

Brandy Verhalen et al.

NEUROPEDIATRICS (2018)

Article Cell Biology

An RNA interference screen identifies druggable regulators of MeCP2 stability

Laura M. Lombardi et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Multidisciplinary Sciences

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division

Isabella Barbiero et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans

Slavica Berber et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway

Mamta Upadhyay et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA

Johanna Ohnheiser et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Medicine, General & Internal

Parkinson's disease

Lorraine V. Kalia et al.

LANCET (2015)

Article Cell Biology

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

Tilman Polonio-Vallon et al.

CELL CYCLE (2014)

Article Biochemistry & Molecular Biology

Homeodomain-interacting protein kinase (Hipk) phosphorylates the small SPOC family protein Spenito

D. N. Dewald et al.

INSECT MOLECULAR BIOLOGY (2014)

Article Biochemistry & Molecular Biology

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

Francesca Siepi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Review Genetics & Heredity

Posttranslational modifications regulate HIPK2, a driver of proliferative diseases

Vera V. Saul et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

Article Cell Biology

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

Vera V. Saul et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2013)

Review Oncology

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer

Gabriella D'Orazi et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

HIPK2 Controls Cytokinesis and Prevents Tetraploidization by Phosphorylating Histone H2B at the Midbody

Cinzia Rinaldo et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

Laureano de la Vega et al.

MOLECULAR CELL (2012)

Article Clinical Neurology

A gene expression phenotype in lymphocytes from friedreich ataxia patients

Giovanni Coppola et al.

ANNALS OF NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

Control of nuclear HIPK2 localization and function by a SUMO interaction motif

Laureano de la Vega et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Neurosciences

Dopamine and α- synuclein dysfunction in Smad3 null mice

Silvia Tapia-Gonzalez et al.

MOLECULAR NEURODEGENERATION (2011)

Review Biochemistry & Molecular Biology

HIPKs: Jack of all trades in basic nuclear activities

Cinzia Rinaldo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)

Article Cell Biology

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek Narendra et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9

Shigeki Arai et al.

FEBS LETTERS (2007)

Article Neurosciences

Essential function of HIPK2 in TGF beta-dependent survival of midbrain dopamine neurons

Jiasheng Zhang et al.

NATURE NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

GM Pierantoni et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)