期刊
BIOCHEMISTRY-MOSCOW
卷 88, 期 3, 页码 337-352出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297923030045
关键词
central nervous system; brain; synaptic plasticity; neurons; astrocytes; oligodendrocytes; microglia; neuronal-glial interactions; lipids; lipid metabolism
Lipids are a diverse group of compounds with various biological functions. They are not only important structural components of cells, but also play a role in intracellular and intercellular signaling. This review discusses the role of lipids and their metabolites in glial cell communication with neurons, focusing on lipid signal molecules and their involvement in synaptic plasticity and neuroplasticity. These findings greatly expand our understanding of the regulatory functions of lipids in neuroglial relationships.
Lipids comprise an extremely heterogeneous group of compounds that perform a wide variety of biological functions. Traditional view of lipids as important structural components of the cell and compounds playing a trophic role is currently being supplemented by information on the possible participation of lipids in signaling, not only intracellular, but also intercellular. The review article discusses current data on the role of lipids and their metabolites formed in glial cells (astrocytes, oligodendrocytes, microglia) in communication of these cells with neurons. In addition to metabolic transformations of lipids in each type of glial cells, special attention is paid to the lipid signal molecules (phosphatidic acid, arachidonic acid and its metabolites, cholesterol, etc.) and the possibility of their participation in realization of synaptic plasticity, as well as in other possible mechanisms associated with neuroplasticity. All these new data can significantly expand our knowledge about the regulatory functions of lipids in neuroglial relationships.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据