相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。High-speed high-resolution data collection on a 200 keV cryo-TEM
Jared Peck et al.
IUCRJ (2022)
Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex
Geng Chen et al.
NATURE COMMUNICATIONS (2022)
Molecular basis for selective activation of DREADD-based chemogenetics
Shicheng Zhang et al.
NATURE (2022)
Inactive and active state structures template selective tools for the human 5-HT5A receptor
Shicheng Zhang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)
Structures in G proteins important for subtype selective receptor binding and subsequent activation
Volker Jelinek et al.
COMMUNICATIONS BIOLOGY (2021)
DeepEMhancer: a deep learning solution for cryo-EM volume post-processing
Ruben Sanchez-Garcia et al.
COMMUNICATIONS BIOLOGY (2021)
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor
Youwen Zhuang et al.
CELL RESEARCH (2021)
β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors
Lauren M. Slosky et al.
CELL (2020)
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Reid H. J. Olsen et al.
NATURE CHEMICAL BIOLOGY (2020)
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Kuglae Kim et al.
CELL (2020)
Topaz-Denoise: general deep denoising models for cryoEM and cryoET
Tristan Bepler et al.
NATURE COMMUNICATIONS (2020)
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
Ali Punjani et al.
NATURE METHODS (2020)
The δ-opioid receptor positive allosteric modulator BMS 986187 is a G-protein-biased allosteric agonist
M. Alexander Stanczyk et al.
BRITISH JOURNAL OF PHARMACOLOGY (2019)
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators
Anthony B. Pinkerton et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells
Qingwen Wan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Terry Kenakin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727
Nathan Robertson et al.
NATURE (2018)
Structural insights into G-protein-coupled receptor allostery
David M. Thal et al.
NATURE (2018)
Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1
Leepakshi Khurana et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Selectivity determinants of GPCR-G-protein binding
Tilman Flock et al.
NATURE (2017)
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
Xiangyu Liu et al.
NATURE (2017)
Structural insight into allosteric modulation of protease-activated receptor 2
Robert K. Y. Cheng et al.
NATURE (2017)
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
Jun Lu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
D4 dopamine receptor high-resolution structures enable the discovery of selective agonists
Sheng Wang et al.
SCIENCE (2017)
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
Jun Lu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
How Ligands Illuminate GPCR Molecular Pharmacology
Daniel Wacker et al.
CELL (2017)
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse
Larry S. Barak et al.
ACS CHEMICAL BIOLOGY (2016)
Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling
Elisa Alvarez-Curto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
Yi Zheng et al.
NATURE (2016)
G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
Sayaka Inagaki et al.
BIOCHEMISTRY (2015)
Universal allosteric mechanism for Gα activation by GPCRs
Tilman Flock et al.
NATURE (2015)
Two disparate ligand-binding sites in the human P2Y1 receptor
Dandan Zhang et al.
NATURE (2015)
Structural prerequisites for G-protein activation by the neurotensin receptor
Brian E. Krumm et al.
NATURE COMMUNICATIONS (2015)
Imidazole-derived agonists for the neurotensin 1 receptor
Paul M. Hershberger et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Molecular control of δ-opioid receptor signalling
Gustavo Fenalti et al.
NATURE (2014)
Deciphering key features in protein structures with the new ENDscript server
Xavier Robert et al.
NUCLEIC ACIDS RESEARCH (2014)
Allosteric sodium in class A GPCR signaling
Vsevolod Katritch et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands
Arthur Christopoulos et al.
PHARMACOLOGICAL REVIEWS (2014)
Structure-Function of the G Protein-Coupled Receptor Superfamily
Vsevolod Katritch et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
OPINION Signalling bias in new drug discovery: detection, quantification and therapeutic impact
Terry Kenakin et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Discovery of ML314, a Brain Penetrant Nonpeptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor
Satyamaheshwar Peddibhotla et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
Wei Liu et al.
SCIENCE (2012)
Distinct Phosphorylation Sites on the β2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
Kelly N. Nobles et al.
SCIENCE SIGNALING (2011)
Allostery in GPCRs: 'MWC' revisited
Meritxell Canals et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Neurotensin expression and outcome of malignant pleural mesothelioma
Marco Alifano et al.
BIOCHIMIE (2010)
Neurotensin Receptor 1 Determines the Outcome of Non-Small Cell Lung Cancer
Marco Alifano et al.
CLINICAL CANCER RESEARCH (2010)
A unique mechanism of β-blocker action:: Carvedilol stimulates β-arrestin signaling
James W. Wisler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Bsoft: Image processing and molecular modeling for electron microscopy
J. Bernard Heymann et al.
JOURNAL OF STRUCTURAL BIOLOGY (2007)
Allosteric modulation of the cannabinoid CB1 receptor
MR Price et al.
MOLECULAR PHARMACOLOGY (2005)
Analysis of allosterism in functional assays
FJ Ehlert
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Automated electron microscope tomography using robust prediction of specimen movements
DN Mastronarde
JOURNAL OF STRUCTURAL BIOLOGY (2005)
Transduction of receptor signals by β-arrestins
RJ Leftowitz et al.
SCIENCE (2005)
The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor
C Watson et al.
MOLECULAR PHARMACOLOGY (2005)
β-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
AM Wilbanks et al.
SCIENCE (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy
PB Rosenthal et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Seven-transmembrane receptors
KL Pierce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Constitutive activation of the neurotensin receptor 1 by mutation of Phe358 in Helix seven
S Barroso et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Increased plasma neurotensin concentrations in patients with Parkinson's disease
RM Schimpff et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2001)
Functional coupling with Gαq and Gαil protein subunits promotes high-affinity agonist binding to the neurotensin receptor NTS-1 expressed in Escherichia coli
R Grisshammer et al.
FEBS LETTERS (2001)
Modeling the functional effects of allosteric modulators at pharmacological receptors: An extension of the two-state model of receptor activation
DA Hall
MOLECULAR PHARMACOLOGY (2000)
分享论文
