4.4 Review

The regulation of meiotic crossover distribution: a coarse solution to a century-old mystery?

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Article Biology

Coarsening dynamics can explain meiotic crossover patterning in both the presence and absence of the synaptonemal complex

John A. Fozard et al.

Summary: The shuffling of genetic material through meiotic crossovers is vital for genetic variation. By studying Arabidopsis mutants lacking the synaptonemal complex (SC), a protein scaffold, researchers have discovered a coarsening mechanism involving the competition for a limited pool of the pro-crossover factor HEI10. This mechanism explains the crossover patterning in SC-defective mutants and wild-type Arabidopsis, highlighting the importance of regulating crossover events.
Article Multidisciplinary Sciences

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex

Jocelyn Haversat et al.

Summary: This study reveals that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with COSA-1 to promote crossover formation and identifies MSH-5 as a CDK-2 phosphorylation target. The data support a model in which CDK-2-mediated phosphorylation and the scaffold-like properties of the MSH5 C-terminal tail together promote the full recruitment and activity of crossover-promoting complexes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Letter Multidisciplinary Sciences

Limitations of gamete sequencing for crossover analysis

Carl Veller et al.

NATURE (2022)

Review Plant Sciences

Crossover patterning in plants

Andrew Lloyd

Summary: Chromatin state, dynamic loading of pro-crossover protein HEI10, and genomic and epigenomic features play important roles in shaping meiotic chromosome patterning in plants. The regulation of crossover formation involves phenomena such as crossover interference, crossover homeostasis, and obligatory crossover. Recent studies implicate HEI10 and ZYP1 as key players in coordinating crossover regulation.

PLANT REPRODUCTION (2022)

Article Multidisciplinary Sciences

Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage

Stephanie Durand et al.

Summary: This study proposes a model for crossover patterning, suggesting that the diffusion of HEI10 along the synaptonemal complex leads to a coarsening process that creates well-spaced crossover-promoting foci. The findings support this model and provide insight into the mechanistic basis of crossover control during meiosis.

NATURE COMMUNICATIONS (2022)

Article Multidisciplinary Sciences

The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis

Laia Capilla-Perez et al.

Summary: The spatial organization of transverse filaments is essential for CO formation during meiosis, with the absence of ZYP1 leading to an unexpected increase in CO formation. The tripartite synaptonemal complex plays a key role in regulating the number and distribution of COs, affecting CO interference and heterochiasmy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis

Martin G. France et al.

Summary: The study on the function of the synaptonemal complex in Arabidopsis indicates that it limits the formation of Class I crossover interference and disrupts the progressive alignment of chromosome axes in plants.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Genetics & Heredity

Architecture and Dynamics of Meiotic Chromosomes

Sarah N. Ur et al.

Summary: Meiotic cell division is a specialized process preparing for sexual reproduction, involving homologous chromosomes identifying each other and forming physical links through DNA recombination. The SMC family cohesin complexes and meiotic chromosome axis play crucial roles in organizing chromosomes and promoting recombination. The synaptonemal complex (SC) ensures high fidelity in meiotic recombination by assembling between homologs and providing feedback.

ANNUAL REVIEW OF GENETICS, VOL 55 (2021)

Review Cell Biology

Let's get physical - mechanisms of crossover interference

Lexy von Diezmann et al.

Summary: Crossover interference is a crucial process in sexual reproduction, but the molecular mechanisms behind it are still debated. Recent research has shed light on how signaling proteins regulate the formation of crossovers, providing new insights into this complex process. These findings contribute to a better understanding of how crossover interference is implemented in meiotic chromosomes.

JOURNAL OF CELL SCIENCE (2021)

Article Multidisciplinary Sciences

Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis

Chris Morgan et al.

Summary: Through quantitative super-resolution cytogenetics and mathematical modeling, this study investigated crossover positioning in Arabidopsis thaliana and found that the process can be explained by a predictive coarsening model. Altering the dosage of the E3 ligase HEI10 was shown to predictably modify crossover interference, suggesting a conserved mechanism may regulate crossover positioning in diverse eukaryotes.

NATURE COMMUNICATIONS (2021)

Review Andrology

Crossover patterns under meiotic chromosome program

Shunxin Wang et al.

Summary: The article discusses the repair of DNA double-strand breaks in meiosis, focusing on the crossover recombination using homologous chromosomes as templates, and the impact of the control mechanisms and abnormal patterns of crossover on fertility issues.

ASIAN JOURNAL OF ANDROLOGY (2021)

Article Agriculture, Dairy & Animal Science

Genetic variation in recombination rate in the pig

Martin Johnsson et al.

Summary: The study assessed the genetic variation in recombination rate along the pig genome and between individuals, confirming known features of the recombination landscape with low but nonzero heritability. Six genomic regions associated with recombination rate were identified, including candidate genes involved in recombination. The findings are consistent with those reported for other vertebrates and highlight the utility of utilizing large-scale livestock data to understand biological processes.

GENETICS SELECTION EVOLUTION (2021)

Article Cell Biology

Identification of novel synaptonemal complex components in C. elegans

Matthew E. Hurlock et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Insights into variation in meiosis from 31,228 human sperm genomes

Avery Davis Bell et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Per-Nucleus Crossover Covariation and Implications for Evolution

Shunxin Wang et al.

Review Biochemistry & Molecular Biology

Crossing and zipping: molecular duties of the ZMM proteins in meiosis

Alexandra Pyatnitskaya et al.

CHROMOSOMA (2019)

Review Biochemistry & Molecular Biology

Crossover Interference, Crossover Maturation, and Human Aneuploidy

Shunxin Wang et al.

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Unleashing meiotic crossovers in hybrid plants

Joiselle Blanche Fernandes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Condensin controls mitotic chromosome stiffness and stability without forming a structurally contiguous scaffold

Mingxuan Sun et al.

CHROMOSOME RESEARCH (2018)

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A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination

H. B. D. Prasada Rao et al.

SCIENCE (2017)

Article Biochemistry & Molecular Biology

Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle

Naveen Kumar Kadri et al.

GENOME RESEARCH (2016)

Article Biochemistry & Molecular Biology

Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

Alistair Miles et al.

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Review Cell Biology

A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis

Denise Zickler et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

Valerie Garcia et al.

NATURE (2015)

Article Multidisciplinary Sciences

Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM

Mathilde Seguela-Arnaud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell Biology

Meiotic Recombination: The Essence of Heredity

Neil Hunter

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

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Topoisomerase II mediates meiotic crossover interference

Liangran Zhang et al.

NATURE (2014)

Article Genetics & Heredity

Common and low-frequency variants associated with genome-wide recombination rate

Augustine Kong et al.

NATURE GENETICS (2014)

Article Multidisciplinary Sciences

Combined fluorescent and electron microscopic imaging unveils the specific properties of two classes of meiotic crossovers

Lorinda K. Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Meiotic chromosome structures constrain and respond to designation of crossover sites

Diana E. Libuda et al.

NATURE (2013)

Article Genetics & Heredity

RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis

April Reynolds et al.

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Article Biotechnology & Applied Microbiology

A high density recombination map of the pig reveals a correlation between sex-specific recombination and GC content

Flavie Tortereau et al.

BMC GENOMICS (2012)

Review Oncology

The spatial regulation of meiotic recombination hotspots: Are all DSB hotspots crossover hotspots?

Maria-Elisabetta Serrentino et al.

EXPERIMENTAL CELL RESEARCH (2012)

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Defining and Detecting Crossover-Interference Mutants in Yeast

Frank Stahl

PLOS ONE (2012)

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Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle

Cynthia Sandor et al.

PLOS GENETICS (2012)

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The genome of the mesopolyploid crop species Brassica rapa

Xiaowu Wang et al.

NATURE GENETICS (2011)

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Variation in Human Recombination Rates and Its Genetic Determinants

Adi Fledel-Alon et al.

PLOS ONE (2011)

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Genetic Interference: Don't Stand So Close to Me

Luke E. Berchowitz et al.

CURRENT GENOMICS (2010)

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Genetic Analysis of Variation in Human Meiotic Recombination

Reshmi Chowdhury et al.

PLOS GENETICS (2009)

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High-resolution mapping of meiotic crossovers and non-crossovers in yeast

Eugenio Mancera et al.

NATURE (2008)

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Sequence variants in the RNF212 gene associate with genome-wide recombination rate

Augustine Kong et al.

SCIENCE (2008)

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Crossover interference underlies sex differences in recombination rates

Petko M. Petkolv et al.

TRENDS IN GENETICS (2007)

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The reference genetic linkage map for the multinational Brassica rapa genome sequencing project

Su Ryun Choi et al.

THEORETICAL AND APPLIED GENETICS (2007)

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The mismatch repair protein MLH1 marks a subset of strongly interfering crossovers in tomato

Franck G. P. Lhuissier et al.

PLANT CELL (2007)

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Two levels of interference in mouse meiotic recombination

Esther de Boer et al.

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Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a zip3-related protein in Caenorhabditis elegans

V Jantsch et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

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A mechanical basis for chromosome function

N Kleckner et al.

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Chromosome-wide control of meiotic crossing over in C-elegans

KJ Hillers et al.

CURRENT BIOLOGY (2003)

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Zip3 provides a link between recombination enzymes and synaptonemal complex proteins

S Agarwal et al.

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Characterization of human crossover interference

KW Broman et al.

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