☆ 4.7 Review

CRISPR/Cas genome editing in triple negative breast cancer: Current situation and future directions

BIOCHEMICAL PHARMACOLOGY (2023)

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Review Genetics & Heredity

Computational Tools and Resources for CRISPR/Cas Genome Editing

Chao Li et al.

Summary: In the past decade, significant progress has been made in developing versatile CRISPR/Cas nucleases and precise genome editors. Computer-assisted tools have played a crucial role in designing sgRNA and analyzing CRISPR/Cas-induced mutations. This review provides insights into the different features of CRISPR/Cas tools, the usage of computer-assisted tools, and the limitations and suggestions for further optimization.

GENOMICS PROTEOMICS & BIOINFORMATICS (2023)

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Review Multidisciplinary Sciences

CRISPR technology: A decade of genome editing is only the beginning

Joy Y. Wang et al.

Summary: The combination of CRISPR genome editing technology and advances in computing and imaging capabilities has brought about a new era in which genetic diseases and individual disease susceptibilities can be predicted and acted upon. This technology has also revolutionized agricultural research and plant breeding by enabling quick identification and alteration of genes responsible for plant traits. In this Review, we discuss the current state of CRISPR-mediated genetic manipulation in human cells, animals, and plants, highlighting successes, challenges, and future prospects.

SCIENCE (2023)

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Article Biophysics

Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer

Jean de Dieu Habimana et al.

Summary: Developing rapid and non-invasive diagnostics for Helicobacter pylori (HP) is crucial to prevent associated diseases. Diagnosing CagA and VacA genotypes can alert active infection and determine suitable therapeutics.

BIOSENSORS & BIOELECTRONICS (2023)

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Article Chemistry, Multidisciplinary

A Proton-Activatable DNA-Based Nanosystem Enables Co-Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy

Feng Li et al.

Summary: This study reports a proton-activatable DNA-based nanosystem that enables co-delivery of Cas9/sgRNA and DNAzyme for combined gene therapy of breast cancer.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biochemistry & Molecular Biology

Genome-wide CRISPR/Cas9 knockout screening uncovers ZNF319 as a novel tumor suppressor critical for breast cancer metastasis

Longlong Wang et al.

Summary: Breast cancer is prone to relapse and metastasize, with ZNF319 identified as a novel metastasis suppressor gene. Higher expression of ZNF319 correlates with better clinical outcomes in breast cancer patients. Knocking down ZNF319 affects cell cycle and proliferation, regulating E2F target genes and G2/M checkpoint in breast cancer progression.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Cell Biology

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Hai-Liang Zhang et al.

Summary: Through CRISPR-Cas9 and kinase inhibitor screening, Zhang et al. found that PKC beta II phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.

NATURE CELL BIOLOGY (2022)

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Article Cell Biology

DSTYK Enhances Chemoresistance in Triple-Negative Breast Cancer Cells

Stella C. Ogbu et al.

Summary: Breast cancer is a prevalent cancer in women, and therapeutic resistance to chemotherapy is a major challenge in improving the treatment outcomes. A protein kinase called DSTYK has been found to play a crucial role in promoting chemoresistance in breast cancer cells, particularly in triple-negative breast cancer. This discovery provides valuable insights and lays the foundation for developing new strategies targeting DSTYK to enhance the efficacy of TNBC therapy.

CELLS (2022)

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Review Pharmacology & Pharmacy

Progress and pitfalls in the use of immunotherapy for patients with triple negative breast cancer

Elisa Agostinetto et al.

Summary: This review focuses on the use of immunotherapeutic strategies in triple negative breast cancer (TNBC), discussing evidence from early and advanced TNBC and novel immunomodulatory approaches. PD-1 blockade has been approved for TNBC treatment, but challenges include predictive biomarker identification and balancing efficacy with toxicity. Evaluation of treatment combinations and new immunotherapeutic strategies beyond PD-1 blockade is ongoing.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2022)

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Article Biochemistry & Molecular Biology

Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity

Connor A. Tsuchida et al.

Summary: This study reveals that the structural features of CasX homologs and their guide RNAs affect the assembly and activity of the R-loop complex and DNA cleavage. By conducting structural engineering, two improved CasX genome-editing tools were obtained with enhanced DNA manipulation efficacy. These results are of great significance for further understanding the mechanism and application of CasX.

MOLECULAR CELL (2022)

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Review Biotechnology & Applied Microbiology

CRISPR/Cas systems: Delivery and application in gene therapy

Jie Huang et al.

Summary: The CRISPR/Cas system is an adaptive immune system in prokaryotes that prevents infection from viruses, phages, and other foreign substances. It cuts the DNA from invading viruses or phages into short fragments that integrate into the CRISPR array, allowing for rapid DNA cutting at the specified target location to protect the host. The CRISPR/Cas system has become one of the most popular gene editing technologies due to its high efficiency, versatility, and simplicity.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Multidisciplinary Sciences

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

Ngoc Tung Tran et al.

Summary: This study establishes a spacer-nick gene correction approach that combines Cas9D10A nickase with a pair of PAM-out sgRNAs, resulting in efficient gene correction with reduced off-target mutations. The results suggest that this approach provides improved safety and suitability for gene therapy.

SCIENCE ADVANCES (2022)

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Article Oncology

MCT4/Lactate Promotes PD-L1 Glycosylation in Triple-Negative Breast Cancer Cells

Xianxian Duan et al.

Summary: This study explored the co-expression analysis of MCT4 and PD-L1 in TNBC and their potential regulatory mechanisms. It was found that MCT4 positively regulated PD-L1 expression and stability through lactate release and glycosylation promotion. These findings provide insights into potential targets for treating TNBC and improving immune checkpoint therapy.

JOURNAL OF ONCOLOGY (2022)

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Review Medicine, Research & Experimental

CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives

Yau-Tuen Chan et al.

Summary: CRISPR-Cas9 is a powerful gene editing tool that allows high-precision genetic engineering of the genomes of all organisms. The latest advancements include genome library screening, which can detect survival-essential and drug resistance genes. This technology has various applications in anti-cancer drug discovery.

THERANOSTICS (2022)

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Review Oncology

CRISPR in cancer biology and therapy

Alyna Katti et al.

Summary: Over the past decade, CRISPR has played a crucial role in biomedical research, particularly in cancer research. It has provided new methods for studying cancer and improving diagnosis and treatment.

NATURE REVIEWS CANCER (2022)

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Article Oncology

PD-L1 status in breast cancer: Current view and perspectives

Semir Vranic et al.

Summary: Breast cancer, traditionally considered not highly immunogenic, has been found to exhibit immunogenicity in some cases, particularly in aggressive triple-negative types. However, challenges remain in identifying patients who would benefit from immunotherapy and in analyzing samples accurately for immune cell targets. Explore exploration of checkpoint inhibitors in breast cancer, specifically in PD-L1 testing, is an important aspect of current research.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy

Xiangrong Song et al.

Summary: CRISPR/Cas systems are efficient and versatile gene editing tools with enormous potential for cancer treatment. While preclinical studies using CRISPR/Cas systems for cancer treatment are underway, efficient and safe in vivo delivery remains a critical challenge for their clinical applications.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Oncology

Targeting RLIP with CRISPR/Cas9 controls tumor growth

Jyotsana Singhal et al.

Summary: This study successfully targeted the RLIP gene in breast cancer cells and knocked down its expression using CRISPR/Cas9 technology, demonstrating its potential to inhibit the proliferation and survival of BC cells in vitro and in vivo.

CARCINOGENESIS (2021)

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Review Microbiology

Harnessing the type ICRISPR-Cassystems for genome editing in prokaryotes

Zeling Xu et al.

Summary: Genetic analysis is essential for the understanding and manipulation of microorganisms, with the CRISPR-Cas system revolutionizing genetics in eukaryotes. However, its application in prokaryotes faces limitations due to diversity in DNA homeostasis and cytotoxicity. Different classes and types of CRISPR-Cas systems in prokaryotes serve as a valuable resource for expanding genetic toolkits.

ENVIRONMENTAL MICROBIOLOGY (2021)

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Review Biotechnology & Applied Microbiology

CRISPR-Cas9: A Preclinical and Clinical Perspective for the Treatment of Human Diseases

Garima Sharma et al.

Summary: The revolutionary CRISPR-Cas9 technology has therapeutic potential against genetic disorders and is being tested in clinical trials for cancer treatment. In addition to therapeutic applications, it can also be used to create genetic animal models for drug discovery. However, challenges and safety concerns still need to be addressed in CRISPR-Cas9-mediated therapeutic approaches.

MOLECULAR THERAPY (2021)

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Article Chemistry, Analytical

Single-nucleotide variant of PIK3CA H1047R gene assay by CRISPR/Cas12a combined with rolling circle amplification

Gaihua Cao et al.

Summary: A method combining CRISPR/Cas12a with RCA technology was developed for ultra-sensitive and specific detection of the SNV of the PIK3CA H1047R gene. This method showed lower detection limit compared to AS-PCR, providing a new idea for medical diagnosis and laying a technical foundation for the study of PI3K/Akt/mTOR signaling pathways.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Multidisciplinary

CRISPR-Cas12a-Based Nucleic Acid Amplification-Free DNA Biosensor via Au Nanoparticle-Assisted Metal-Enhanced Fluorescence and Colorimetric Analysis

Jin-Ha Choi et al.

Summary: A non-nucleic acid amplification fluorescent biosensor using gold nanoparticles for metal-enhanced fluorescence detection of cfDNA has been developed in this study, allowing rapid and highly sensitive detection of BRCA-1. This sensor is highly selective and can be widely applied for the measurement of other nucleic acid biomarkers.

NANO LETTERS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

An Overview of PARP Inhibitors for the Treatment of Breast Cancer

Laura Cortesi et al.

Summary: Loss-of-function mutations in BRCA1 and BRCA2 are detected in at least 5% of unselected patients with breast cancer, and PARP inhibitors such as Olaparib and talazoparib have demonstrated significant progression-free survival benefits for some patients. Additional studies are ongoing to explore the efficacy and safety of PARP inhibitors in different patient populations and in combination therapies.

TARGETED ONCOLOGY (2021)

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Review Medicine, Research & Experimental

Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer

Tian Tian et al.

Summary: TNBC, the most malignant subtype of breast cancer, is characterized by high rates of cell proliferation and poor prognosis. Chemotherapy is the primary therapeutic strategy, but targeted therapies for TNBC are lacking. CircRNAs show potential as biomarkers for TNBC diagnosis, prognosis, and treatment, but further research is needed to understand their functions.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Multidisciplinary Sciences

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Kasper Fugger et al.

Summary: Mutations in BRCA1 or BRCA2 genes increase the risk of breast and ovarian cancer, but inhibiting DNPH1 can enhance the sensitivity of BRCA-deficient cells to PARP inhibitors. Targeting DNPH1 provides a promising strategy for hypersensitizing BRCA-deficient cancers to PARPi therapy.

SCIENCE (2021)

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Review Genetics & Heredity

New Insights into the Therapeutic Applications of CRISPR/Cas9 Genome Editing in Breast Cancer

Munazza Ahmed et al.

Summary: Breast cancer is a prevalent and heterogeneous disease with complex pathogenesis, often treated by alleviating symptoms rather than targeting mutations. CRISPR/Cas9 is a groundbreaking gene-editing tool that offers a promising new approach for the treatment of breast cancer, surpassing previous methods in terms of simplicity, efficiency, and affordability.

GENES (2021)

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Article Oncology

Evaluation of Racial/Ethnic Differences in Treatment and Mortality Among Women With Triple-Negative Breast Cancer

Beomyoung Cho et al.

Summary: This study examined the differences in treatment and outcomes between African American and White women with TNBC, finding that African American women had lower odds of receiving surgery and chemotherapy compared to White women, leading to a significantly higher risk of breast cancer mortality.

JAMA ONCOLOGY (2021)

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Article Chemistry, Analytical

CRISPR/Cas-Based In Vitro Diagnostic Platforms for Cancer Biomarker Detection

Shaohua Gong et al.

Summary: Timely cancer diagnosis is crucial for improving survival rates, and body fluid cancer biomarker detection offers a non-invasive approach. The CRISPR/Cas-based in vitro diagnosis simplifies detection procedures, enhances sensitivity and specificity, and holds great promise as the next-generation molecular diagnostic technology for various cancer biomarkers. Challenges and perspectives of CRISPR/Cas-based strategies for cancer biomarkers are also discussed.

ANALYTICAL CHEMISTRY (2021)

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Review Chemistry, Analytical

Ultrasensitive detection of gene-PIK3CAH1047R mutation based on cascaded strand displacement amplification and trans-cleavage ability of CRISPR/Cas12a

Yuanyi Deng et al.

Summary: A fluorescent biosensor combining cascaded strand displacement amplification and CRISPR/Cas12a trans-cleavage ability was established for ultra-sensitive detection of low abundance gene-PIK3CA(H1047R) mutation in breast cancer. The biosensor showed improved sensitivity compared to previous methods, achieving detection of gene-PIK3CA(H1047R) mutation as low as 0.001% in human serum samples. This proposed biosensor has potential applications in low-abundance gene-PIK3CA(H1047R) mutation detection.

TALANTA (2021)

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Article Multidisciplinary Sciences

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Lauren Giuffrida et al.

Summary: The study showed that targeting the A(2A)R gene using CRISPR/Cas9 significantly enhances the efficacy of CAR T cells, leading to improved survival rates in mice and potential for enhanced tumor control.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy

Meiou Dai et al.

Summary: Through in vivo genome-wide CRISPR screening, tumor regulatory functions for components of the mTORC1/2 complex and YAP/Hippo pathway were identified in TNBC, showing that pharmacological inhibition of mTOR and YAP can reduce tumor growth in vivo.

NATURE COMMUNICATIONS (2021)

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Review Oncology

Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review

Sergiusz Lukasiewicz et al.

Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with molecular subtypes providing new insights into treatment strategies and patient stratifications that impact the management of breast cancer patients.

CANCERS (2021)

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Review Engineering, Biomedical

CRISPR-based diagnostics

Michael M. Kaminski et al.

Summary: This Review summarizes the rapidly expanding toolbox of CRISPR-based diagnostics, highlighting their applications in real-time diagnosis. It mentions that nucleic acid-based diagnostics are sensitive and specific, but most require expensive equipment and trained personnel.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Chemistry, Multidisciplinary

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules

Wei Feng et al.

Summary: The advancement of CRISPR-Cas technology has revolutionized genome editing and transcriptional modulation, as well as molecular detection of diverse targets. Integrating CRISPR-Cas systems with nucleic acid amplification strategies enables amplified detection signals, enrichment of low-abundance targets, improved specificity and sensitivity, and development of point-of-care diagnostic techniques.

CHEMICAL SCIENCE (2021)

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Article Pharmacology & Pharmacy

Cdk5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity

Huan Deng et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Oncology

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Johanna F. Dekkers et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2020)

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Article Chemistry, Analytical

RCasFISH: CRISPR/dCas9-Mediated in Situ Imaging of mRNA Transcripts in Fixed Cells and Tissues

Meng Wang et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biophysics

An integrated electrochemical biosensor based on target-triggered strand displacement amplification and four-way DNA junction towards ultrasensitive detection of PIK3CA gene mutation

Tong Wang et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Biochemistry & Molecular Biology

In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer

Stefano Annunziato et al.

EMBO JOURNAL (2020)

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Article Multidisciplinary Sciences

CRISPR-engineered T cells in patients with refractory cancer

Edward A. Stadtmauer et al.

SCIENCE (2020)

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Article Cell & Tissue Engineering

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Till Ringel et al.

CELL STEM CELL (2020)

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Article Oncology

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

Devikala Gurusamy et al.

CANCER CELL (2020)

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CAR T-cell therapy for triple-negative breast cancer: Where we are

Yuetao Xie et al.

CANCER LETTERS (2020)

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Review Cell Biology

CRISPR system: Discovery, development and off-target detection

Shengmiao Chen et al.

CELLULAR SIGNALLING (2020)

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Review Cell Biology

Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing

Muhammad Naeem et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

A scoutRNA Is Required for Some Type V CRISPR-Cas Systems

Lucas B. Harrington et al.

MOLECULAR CELL (2020)

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Review Biotechnology & Applied Microbiology

Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors

Andrew V. Anzalone et al.

NATURE BIOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Samantha M. Carlisle et al.

SCIENTIFIC REPORTS (2020)

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Review Oncology

Triple-negative breast cancer therapy: Current and future perspectives (Review)

Kwang-Ai Won et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2020)

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Article Plant Sciences

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

Corena Grant et al.

JOURNAL OF NATURAL PRODUCTS (2020)

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Review Medicine, Research & Experimental

CRISPR/Cas9: A powerful genome editing technique for the treatment of cancer cells with present challenges and future directions

Abu Hazafa et al.

LIFE SCIENCES (2020)

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Article Cell Biology

Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

Clarissa Ribeiro Reily Rocha et al.

CELLS (2020)

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Review Cell & Tissue Engineering

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

Delilah Hendriks et al.

CELL STEM CELL (2020)

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Review Biochemistry & Molecular Biology

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Hongyi Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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DNA Nanotechnology-Enabled Drug Delivery Systems

Qinqin Hu et al.

CHEMICAL REVIEWS (2019)

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Article Oncology

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Yi-Zhou Jiang et al.

CANCER CELL (2019)

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Article Multidisciplinary Sciences

CasX enzymes comprise a distinct family of RNA-guided genome editors

Jun-Jie Liu et al.

NATURE (2019)

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Article Medicine, General & Internal

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer

A. Bardia et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Oncology

CRISPR-Cas9 for cancer therapy: Opportunities and challenges

Minjiang Chen et al.

CANCER LETTERS (2019)

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Article Multidisciplinary Sciences

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

Fiona M. Behan et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

Leonie Voorwerk et al.

NATURE MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells

Meng Yang et al.

ONCOTARGETS AND THERAPY (2019)

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Article Oncology

ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer

Gaurav Pandey et al.

CANCERS (2019)

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Article Genetics & Heredity

High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer

Kevin Grosselin et al.

NATURE GENETICS (2019)

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Article Oncology

CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions

Wanghong Hu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

Synthetic switch to minimize CRISPR off-target effects by self-restricting Cas9 transcription and translation

Chih-Che Shen et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Multidisciplinary Sciences

Engineering of CRISPR-Cas12b for human genome editing

Jonathan Strecker et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Tumour suppression by targeted intravenous non-viral CRISPRa using dendritic polymers

Jessica A. Kretzmann et al.

CHEMICAL SCIENCE (2019)

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Article Multidisciplinary Sciences

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Beeke Wienert et al.

SCIENCE (2019)

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Article Oncology

Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis

Y. Bareche et al.

ANNALS OF ONCOLOGY (2018)

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Review Engineering, Biomedical

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

Ling Li et al.

BIOMATERIALS (2018)

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Article Pharmacology & Pharmacy

Delivering CRISPR: a review of the challenges and approaches

Christopher A. Lino et al.

DRUG DELIVERY (2018)

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Review Immunology

CRISPR/Cas9: A tool for immunological research

Katharina Hochheiser et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

Christopher R. Cromwell et al.

NATURE COMMUNICATIONS (2018)

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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt et al.

NATURE COMMUNICATIONS (2018)

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Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer

Yinnan Chen et al.

ADVANCED SCIENCE (2018)

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ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway

Khoa Nguyen et al.

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The shieldin complex mediates 53BP1-dependent DNA repair

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Organoids in cancer research

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Breast Cancer Immunotherapy: Facts and Hopes

Leisha A. Emens

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New CRISPR-Cas systems from uncultivated microbes

David Burstein et al.

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Nadia Harbeck et al.

LANCET (2017)

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C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism

Liang Liu et al.

MOLECULAR CELL (2017)

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Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem et al.

NATURE (2017)

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Letter Biochemical Research Methods

被撤回的出版物: Unexpected mutations after CRISPR-Cas9 editing in vivo (Retracted article. See vol. 14, pg. 547, 2017)

Kellie A. Schaefer et al.

NATURE METHODS (2017)

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Clinical utility of gene-expression signatures in early stage breast cancer

Maryann Kwa et al.

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Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Jarno Drost et al.

SCIENCE (2017)

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CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

Levi J. Rupp et al.

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E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer

Liqiu Liao et al.

CANCER RESEARCH (2017)

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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

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