Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p

Article Oncology

Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis

Siyang Chen et al.

Summary: circ-AGFG1 acts as an oncogene in esophageal squamous cell carcinoma (ESCC), promoting the malignant potential and glutamine catabolism of ESCC cells by targeting the miR-497-5p/SLC1A5 axis.

ANTI-CANCER DRUGS (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Circ_0008726 promotes malignant progression of ESCC cells through miR-206/HOXA13 pathway

Tingting Han et al.

Summary: In this study, circ_0008726 was found to exert carcinogenic effects on ESCC cells by targeting the miR-206/HOXA13 axis, regulating cell proliferation, invasion, angiogenesis, and apoptosis.

GENERAL THORACIC AND CARDIOVASCULAR SURGERY (2023)

添加到收藏夹

Article Oncology

circUSP34 accelerates osteosarcoma malignant progression by sponging miR-16-5p

Jingbing Lou et al.

Summary: Osteosarcoma (OS) is a primary and highly malignant mesenchymal tissue tumor with unclear pathological mechanisms. This study found that circUSP34 promotes the proliferation, migration, and invasion of OS by sponging miR-16-5p, suggesting it as a potential therapeutic target and biomarker.

CANCER SCIENCE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circular RNA hsa_circ_0003823 promotes the Tumor Progression, Metastasis and Apatinib Resistance of Esophageal Squamous Cell Carcinoma by miR-607/CRISP3 Axis

Yu-Ming Wang et al.

Summary: In this study, we elucidated the function of hsa_circ_0003823 in promoting tumor progression, metastasis, and Apatinib resistance of ESCC through the miR-607/CRISP3 axis. Our findings suggest that hsa_circ_0003823 may serve as a potential therapeutic target for overcoming Apatinib resistance in ESCC patients.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Surgery

MicroRNA-140 Represses Esophageal Cancer Progression via Targeting ZEB2 to Regulate Wnt/β-Catenin Pathway

Song Yang et al.

Summary: The study demonstrated that miR-140 inhibited the development of esophageal cancer by targeting ZEB2 and inactivating the Wnt/β-catenin pathway, both in vitro and in vivo.

JOURNAL OF SURGICAL RESEARCH (2021)

添加到收藏夹

Article Oncology

Curcumin suppresses renal carcinoma tumorigenesis by regulating circ-FNDC3B/miR-138-5p/IGF2 axis

Li Xue et al.

Summary: The study revealed that curcumin could suppress renal carcinoma cell proliferation and promote apoptosis by regulating the circ-FNDC3B/miR-138-5p/IGF2 axis, ultimately reducing the incidence of renal carcinoma. Moreover, in vivo experiments also confirmed that curcumin could decrease xenograft tumor growth.

ANTI-CANCER DRUGS (2021)

添加到收藏夹

Article Oncology

miR-17-5p and miR-4443 Promote Esophageal Squamous Cell Carcinoma Development by Targeting TIMP2

Xiaojun Wang et al.

Summary: The study identified that miR-17-5p and miR-4443 are upregulated in ESCC tissues and promote tumor progression by regulating the TIMP2 gene. These two miRNAs may serve as novel molecular targets for ESCC treatment.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Hong-Yu Shen et al.

Summary: The study revealed that Circ_0001361 was up-regulated in LUAD tissues and cells, while miR-525-5p was down-regulated. Functional experiments demonstrated that Circ_0001361 promoted LUAD cell growth and metastasis. Mechanistically, Circ_0001361 acted as a sponge for miR-525-5p to up-regulate the downstream target VMA21 level, contributing to the malignant phenotypes of LUAD cells.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Biology

CircRNA PLOD2 enhances ovarian cancer propagation by controlling miR-378

Xiaoqiang Wei et al.

Summary: Circular RNA circ-LOPD2 has been identified as a miR-378 sponge that promotes the proliferation of ovarian cancer cells, potentially contributing to the progression of ovarian cancer.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

添加到收藏夹

Article Oncology

Circular RNA 0014715 Facilitates Cell Proliferation and Inhibits Apoptosis in Esophageal Squamous Cell Carcinoma

Hao Zhang et al.

Summary: The study demonstrated that circ_0014715 is highly expressed in esophageal squamous cell carcinoma tissues and cell lines. High expression of circ_0014715 was associated with nerve invasion, vascular invasion, advanced TNM stage, and poor differentiation grade. Knockdown of circ_0014715 inhibited cell proliferation, migration, invasion, wound healing, and induced cell apoptosis, while overexpression of circ_0014715 had the opposite effects. This suggests that circ_0014715 plays a crucial role in the pathogenesis and development of ESCC.

CANCER MANAGEMENT AND RESEARCH (2021)

添加到收藏夹

Article Oncology

Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/BCL2 signaling pathway

Deheng Li et al.

Summary: A novel upregulated circRNA, circSERPINE2, was identified in glioblastoma, promoting tumor cell proliferation and progression by sponging miRNAs and enhancing the expression of the anti-apoptosis gene BCL2. This study reveals the biological function and mechanism of circSERPINE2 in glioblastoma progression, suggesting its potential as a therapeutic target.

MOLECULAR THERAPY-ONCOLYTICS (2021)

添加到收藏夹

Article Oncology

Circular RNA BMI1 Serves as a Potential Target for Diagnosis and Treatment in Esophageal Cancer

Qian Zhao et al.

Summary: The study revealed that the expression of circ-BMI1 is significantly down-regulated in esophageal cancer, and overexpression of circ-BMI1 can inhibit the proliferation, migration, and colony formation of Eca109 cells, as well as tumor growth in nude mice. These findings suggest that circ-BMI1 may be a potential target for diagnosis and treatment in esophageal cancer.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology