4.6 Article

Epidermal growth factor represses differentiation of mouse trophoblast stem cells into spongiotrophoblast cells via epidermal growth factor receptor

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N-Oleoyldopamine promotes the differentiation of mouse trophoblast stem cells into parietal trophoblast giant cells

Kenta Nishitani et al.

Summary: This study investigated the molecular mechanisms of trophoblast cell differentiation using mouse trophoblast stem cells. The researchers identified N-oleoyldopamine (OLDA) as a compound that promotes the differentiation of trophoblast cells into parietal trophoblast giant cells and represses their differentiation into spongiotrophoblast cells. They also discovered that OLDA regulates the expression of Fosl1, a key regulatory factor in trophoblast cell differentiation.

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