Pyridine C(sp2)-H bond functionalization under transition-metal and rare earth metal catalysis

Review Chemistry, Multidisciplinary

Toolbox for Distal C-H Bond Functionalizations in Organic Molecules

Soumya Kumar Sinha et al.

Summary: Transition-metal-catalyzed C-H activation is a contemporary synthetic approach that has significant impact and importance in the synthesis of natural products and pharmaceutical drugs.

CHEMICAL REVIEWS (2022)

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Review Chemistry, Physical

Recent Advances in Transition-Metal-Catalyzed C-H Alkylation with Three-Membered Rings

Hui-Hong Wang et al.

Summary: Transition-metal-catalyzed alkylation reactions involving C-H activation and ring scission have developed greatly in recent years. Strategies utilizing nitrogen-containing directing groups, pre-existing functional groups, and Catellani-type intermediates have provided rapid access to oxygen- or nitrogen-containing heterocyclic ring systems.

ACS CATALYSIS (2022)

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Review Chemistry, Applied

Transition-Metal-Catalyzed, Chelation-Assisted C-H Alkenylation and Allylation of Organic Molecules with Unactivated Alkenes

Ravichandran Logeswaran et al.

Summary: Olefins are important building blocks in synthetic organic chemistry and their functionalization has become a powerful method for constructing complex organic molecules. Despite some limitations, significant progress has been made in chelation-assisted C-H olefination reactions in recent years. This review describes the recent advances in these reactions, including the use of transition metals and base-assisted deprotonation pathways for the alkenylation and allylation of unactivated olefins.

ADVANCED SYNTHESIS & CATALYSIS (2022)

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Article Chemistry, Multidisciplinary

Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives

Demeng Xie et al.

Summary: This research presents the use of alkyl sulfoxides as precursors to radicals in the synthesis of pyridine derivatives. It demonstrates that alkyl sulfoxides, N-methoxy pyridinium salts, and fluoride anions form electron donor-acceptor complexes in solution, which can undergo a radical chain process upon visible light irradiation to produce various pyridine derivatives efficiently. The broad scope of this reaction extends to different sulfoxides and N-methoxy pyridiniums. The synthetic versatility of sulfoxides as radical precursors adds to their significance as a useful tool in chemistry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation

Jun-Bao Ma et al.

Summary: This study describes a novel method for enantioselective para-C-H activation of pyridines using a Ni-Al bimetallic catalyst system and NHC ligand, enabling the efficient synthesis of enantioenriched 1,1-diarylalkanes containing pyridine moieties.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Chemistry, Multidisciplinary

N-Functionalized Pyridinium Salts: A New Chapter for Site-Selective Pyridine C-H Functionalization via Radical-Based Processes under Visible Light Irradiation

Myojeong Kim et al.

Summary: This article provides a comprehensive overview of the development of N-functionalized pyridinium salts and summarizes the cornerstones of organic reactions that successfully employ these pyridinium salts under visible light conditions. Major advances in the field are systematically categorized based on the pyridines' N-substituent, N-X (X = O, N, C, and SO2CF3), and its reactivity patterns.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Review Chemistry, Physical

Recent Advances in Rare-Earth Metal-Catalyzed C-H Functionalization Reactions

Qianlin Sun et al.

Summary: Rare-earth metal-catalyzed C-H functionalization has made significant progress in the past decade, showing unique selectivity and complementary reactivity.

CHEMCATCHEM (2022)

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Article Chemistry, Inorganic & Nuclear

Substrate Facilitating Roles in Rare-Earth-Catalyzed C-H Alkenylation of Pyridines with Allenes: Mechanism and Origins of Regio- and Stereoselectivity

Ping Wu et al.

Summary: This study reveals the facilitating role of coordinating substrates and the potential impact of heteroatom-containing substrates in rare-earth-catalyzed C-H activation processes through careful theoretical studies on a model reaction. Switchable mechanisms were found to be effective in other types of C-H bonds by adjusting catalyst steric surroundings.

INORGANIC CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Enantioselective C2-H Alkylation of Pyridines with 1,3-Dienes via Ni-Al Bimetallic Catalysis

Jiang-Fei Li et al.

Summary: A chiral phosphine oxide-ligated Ni-Al bimetallic catalyst was successfully utilized for an enantioselective C2-H alkylation of pyridines, showing compatibility with a wide range of pyridine substrates and providing high yields and enantioselectivities.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Chemistry, Multidisciplinary

Palladium-catalyzed oxidative arene C-H alkenylation reactions involving olefins

Asier Carral-Menoyo et al.

Summary: The palladium-catalyzed selective C-H alkenylation reaction is an efficient, economical, and environmentally friendly method for constructing carbon-carbon bonds. It provides a powerful tool for synthesizing conjugated organic molecules and enabling late-stage functionalization. The understanding of its mechanism and development of efficient chiral catalysts have expanded its application.

TRENDS IN CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

One-step synthesis of polynitropyridine-based thermostable and low sensitive energetic materials

Qian Wang et al.

Summary: In this study, two energetic compounds based on a 3,5-dinitropyridine backbone were synthesized and characterized. They exhibit high thermal stability and insensitivity, making them promising candidates for thermostable and insensitive explosives.

ENERGETIC MATERIALS FRONTIERS (2022)

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Review Chemistry, Organic

Recent progress in rare-earth metal-catalyzed sp2 and sp3 C-H functionalization to construct C-C and C-heteroelement bonds

Kapileswar Seth

Summary: C-H functionalization is an important organic transformation method to construct C-C and C-heteroatom bonds, leading to diverse molecular structures in chemical synthesis. In recent years, significant progress has been made in C-C and C-heteroatom bond formation under rare-earth metal catalysis. This review presents an overview of the latest research on various types of rare-earth metal-catalyzed organic transformations, as well as reports on sp(2) and sp(3) C-H functionalization under the influence of rare-earth metal elements.

ORGANIC CHEMISTRY FRONTIERS (2022)

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Article Chemistry, Medicinal

US FDA Approved Drugs from 2015-June 2020: A Perspective

Priyadeep Bhutani et al.

Summary: This study compiled and analyzed 245 drugs approved by the U.S. FDA from 2015 to June 2020, focusing on cancer, infectious diseases, neurological conditions, and genetic, metabolic, cardiovascular disorders. The analysis also looked at the structural, elemental, and functional group diversity among the approved drugs, as well as drug-likeness for the approved drugs.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

C-H Activation: Toward Sustainability and Applications

Toryn Dalton et al.

Summary: The field of green chemistry has been evolving for over two decades, with a focus on conserving natural resources and protecting the environment through judicious synthetic routes and materials choices. Current research efforts are aimed at overcoming sustainability challenges in C-H activation, including seeking abundant metal catalysts and introducing bio-derived solvents. Industrial uptake will be crucial for the future growth of this field, urging researchers to strive towards sustainable C-H activation.

ACS CENTRAL SCIENCE (2021)

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Review Chemistry, Organic

Recent advances in catalytic enantioselective direct C-H bond functionalization of electron-deficient N-containing heteroarenes

Xiao-Lan Liu et al.

Summary: This review summarizes the rapid progress in the catalytic asymmetric C-H functionalization of N-containing heteroarenes and discusses the challenges and potential of the field in the current stage.

ORGANIC CHEMISTRY FRONTIERS (2021)

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Article Chemistry, Applied

Ortho-C-H addition of 2-substituted pyridines with alkenes and imines enabled by mono(phosphinoamido)-rare earth complexes

Hailong Lin et al.

Summary: In this study, a special catalytic performance of mono(phosphinoamido)-ligated rare earth complexes in ortho-C-H functionalization of pyridines with nonpolar alkenes and polar imines was reported. The complexes showed high efficiency in synthesizing a variety of ortho-alkylated and ortho-aminoalkylated pyridine derivatives with good yields and excellent regioselectivity and chemoselectivity.

APPLIED ORGANOMETALLIC CHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Decoding Directing Groups and Their Pivotal Role in C-H Activation

Karunanidhi Murali et al.

Summary: C-H functionalization has made significant advancements in synthetic organic chemistry, offering promising prospects in drug development and molecular architecture. The employment of novel metal catalysts and metal-free organic ligands has enabled selective activation of C-H bonds, overcoming previous challenges faced by chemists.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Review Chemistry, Organic

Synthesis of 2,2'-Bipyridines through Catalytic C-C Bond Formations from C-H Bonds

Wided Hagui et al.

Summary: This review describes homogenous catalytic methodologies for synthesizing 2,2'-bipyridines through C-C bond formation from C-H bond cleavage. Three main approaches are discussed, including dimerization of (activated) pyridines to form C2-C2' bond, C-H bond heteroarylation of activated pyridines, and late-stage functionalization of (activated) 2,2'-bipyridines. The scope, limitations, and relevant reaction mechanisms of each method are also discussed.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

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Article Chemistry, Organic

C2-selective alkylation of pyridines by rhodium-aluminum complexes

Naofumi Hara et al.

Summary: This study reports a C2-and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh-Al catalyst. Experimental results show that the use of aliphatic alkenes exclusively affords linear alkylation products, while vinylarenes mainly afford branched alkylation products. The details of the reaction mechanism, revealed by DFT calculations, indicate that the reductive elimination of the products is rate-determining, consistent with experimental results. The origin of the linear/branched selectivity is elucidated based on deformation/interaction analysis.

TETRAHEDRON (2021)

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Review Chemistry, Multidisciplinary

Late-stage C-H functionalization offers new opportunities in drug discovery

Lucas Guillemard et al.

Summary: In the past decade, the introduction of late-stage functionalization methodologies has significantly advanced the landscape of molecular synthesis. Particularly, C-H functionalization approaches have led to improvements in resource economy and new strategies for drug discovery. However, challenges and limitations in current LSF methods indicate the need for future improvements and development of new approaches.

NATURE REVIEWS CHEMISTRY (2021)

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Article Multidisciplinary Sciences

C-H activation

Torben Rogge et al.

Summary: C-H activation has emerged as a powerful platform for molecular syntheses in various fields including natural product syntheses, pharmaceutical industries, and material sciences. This Primer summarizes best practices for experimental set-up, data deposition, and key developments in C-H activation, as well as discussing its applications and limitations.

NATURE REVIEWS METHODS PRIMERS (2021)

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Article Chemistry, Organic

Rhodium(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2′-bipyridine derivatives with sulfoxonium ylides

Mengjia Chen et al.

Summary: A novel protocol for Rh(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2 '-bipyridine derivatives with sulfoxonium ylides has been reported, providing a facile approach to synthesize structurally diverse acylmethylated 2,2 '-bipyridine derivatives and acyl pyrido[2,3-a]indolizines with a broad range of functional group tolerance.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

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Article Chemistry, Applied

Rare-Earth-Metal-Catalyzed Synthesis of Azaindolines and Naphthyridines via C-H Cyclization of Functionalized Pyridines

Pengqing Ye et al.

ADVANCED SYNTHESIS & CATALYSIS (2020)

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Article Chemistry, Organic

Transition-Metal-Free and Site-Selective Selenylation of Heterocyclic N-Oxides in Anisole as a Green Solvent

Suk Hun Lee et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

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Article Chemistry, Organic

NH4I-Triggered [4+2] Annulation of α,β-Unsaturated Ketoxime Acetates with N-Acetyl Enamides for the Synthesis of Pyridines

Jindian Duan et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

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Article Chemistry, Organic

Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes

Wenjing Li et al.

ORGANIC LETTERS (2020)

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Article Chemistry, Organic

Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes

Wenjing Li et al.

ORGANIC LETTERS (2020)

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Article Chemistry, Multidisciplinary

A novel approach for rhodium(iii)-catalyzed C-H functionalization of 2,2′-bipyridine derivatives with alkynes: a significant substituent effect

Shaonan Wu et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Synthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties

Zhiwei Chen et al.

ARABIAN JOURNAL OF CHEMISTRY (2019)

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Review Chemistry, Multidisciplinary

Beyond Friedel and Crafts: Directed Alkylation of C-H Bonds in Arenes

Gwilherm Evano et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Chemistry, Multidisciplinary

Recent Advances in Minisci-Type Reactions

Rupert S. J. Proctor et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis

Wu-Bin Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Review Chemistry, Organic

Advancements in Visible-Light-Enabled Radical C(sp)2-H Alkylation of (Hetero)arenes

Alexandra C. Sun et al.

SYNTHESIS-STUTTGART (2019)

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Article Chemistry, Inorganic & Nuclear

Characterization of Rh-Al Bond in Rh(PAIP) (PAIP = Pincer-type Diphosphino-Aluminyl Ligand) in Comparison with Rh(L)(PMe3)2 (L = AlMe2, Al(NMe2)2, BR2, SiR3, CH3, Cl, or OCH3): Theoretical Insight

Nishamol Kuriakose et al.

INORGANIC CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst

Lichen Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Organic

Rhodium(III)-Catalyzed Regioselective C3-H Acylmethylation of [2,2′-Bipyridine]-6-carboxamides with Sulfoxonium Ylides

Jia Yu et al.

ORGANIC LETTERS (2019)

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Review Chemistry, Multidisciplinary

Recent advances of allenes in the first-row transition metals catalyzed C-H activation reactions

Xiang-Lei Han et al.

CHINESE CHEMICAL LETTERS (2019)

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Review Chemistry, Multidisciplinary

3d Transition Metals for C-H Activation

Parthasarathy Gandeepan et al.

CHEMICAL REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Direct ortho-C-H Aminoalkylation of 2-Substituted Pyridine Derivatives Catalyzed by Yttrium Complexes with N,N′-Diarylethylenediamido Ligands

Abhinanda Kundu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Multidisciplinary

Rhodium Complexes Bearing PAIP Pincer Ligands

Naofumi Hara et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Biochemistry & Molecular Biology

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Mohamed El-Naggar et al.

MOLECULES (2018)

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Article Chemistry, Multidisciplinary

Reductive C2-Alkylation of Pyridine and Quinoline N-Oxides Using Wittig Reagents

Sangil Han et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Chemistry, Inorganic & Nuclear

Addition of C-H Bonds of Pyridine Derivatives to Alkenes Catalyzed by Zirconium Complexes Bearing Amine-Bridged Bis(phenolato) Ligands

Qiu Sun et al.

INORGANIC CHEMISTRY (2018)

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Article Chemistry, Organic

Palladium-Catalyzed Site-Selective C-H Arylation of 2,2 '-Bipyridine-6-carboxamides via a Rollover Cyclometalation Pathway

Jia Yu et al.

ORGANIC LETTERS (2018)

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Article Chemistry, Multidisciplinary

[2,2′-Bipyridin]-6(1H)-one, a Truly Cooperating Ligand in the Palladium-Mediated C-H Activation Step: Experimental Evidence in the Direct C-3 Arylation of Pyridine

Vanesa Salamanca et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Organic

Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines

Yang Zeng et al.

ORGANIC LETTERS (2017)

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Review Chemistry, Multidisciplinary

Transition-Metal-Catalyzed C-H Alkylation Using Alkenes

Zhe Dong et al.

CHEMICAL REVIEWS (2017)

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Review Chemistry, Multidisciplinary

C-H Functionalization of Azines

Kei Murakami et al.

CHEMICAL REVIEWS (2017)

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Article Chemistry, Multidisciplinary

Base-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation

Gael Tran et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

para-Selective C-H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis

Lichen Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Review Chemistry, Multidisciplinary

Dancing with Energetic Nitrogen Atoms: Versatile N-Functionalization Strategies for N-Heterocyclic Frameworks in High Energy Density Materials

Ping Yin et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

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Article Chemistry, Multidisciplinary

Transition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents

Woohyun Jo et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Chemistry, Multidisciplinary

Rhodium-catalyzed selective C-H functionalization of NNN tridentate chelating compounds via a rollover pathway

Seung Youn Hong et al.

CHEMICAL COMMUNICATIONS (2016)

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Article Chemistry, Multidisciplinary

Transition-Metal-Catalyzed Redox-Neutral and Redox-Green C-H Bond Functionalization

Hongli Wang et al.

CHEMICAL RECORD (2016)

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Article Chemistry, Multidisciplinary

Selective Functionalization of Pyridines via Heterocyclic Phosphonium Salts

Michael C. Hilton et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Article Chemistry, Organic

Palladium-catalyzed direct C-H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates

Mengli Li et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

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Article Chemistry, Organic

Pd(II)-Catalyzed C3-Selective Arylation of Pyridine with (Hetero)arenes

Guo-Lin Gao et al.

ORGANIC LETTERS (2016)

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Article Chemistry, Multidisciplinary

Catalytic C-H Bond Addition of Pyridines to Allenes by a Rare-Earth Catalyst

Guoyong Song et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

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Article Chemistry, Organic

Copper-Mediated Formally Dehydrative Biaryl Coupling of Azine N-Oxides and Oxazoles

Riko Odani et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

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Article Chemistry, Organic

Palladium-Catalyzed Regioselective Benzylation-Annulation of Pyridine N-Oxides with Toluene Derivatives via Multiple C-H Bond Activations: Benzylation versus Arylation

Ebrahim Kianmehr et al.

ORGANIC LETTERS (2015)

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Article Chemistry, Inorganic & Nuclear

Rhodium(III)-Catalyzed Activation and Functionalization of Pyridine C-H Bond by Exploring a Unique Double Role of N-Heterocyclic Carbene-Pyridyl Ligand Platform

Ranjeesh Thenarukandiyil et al.

ORGANOMETALLICS (2015)

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Article Chemistry, Medicinal

Cytotoxic 1,5-diaryl-3-oxo-1,5-pentadienes: An assessment and comparison of membrane permeability using Caco-2 and MDCK monolayers

Ravi S. P. Singh et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

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Article Chemistry, Multidisciplinary

Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: one-pot synthesis of 2-arylpyridines

Yan Shen et al.

CHEMICAL COMMUNICATIONS (2014)

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Article Chemistry, Multidisciplinary

Palladium-catalyzed oxidative CH/CH cross-coupling of pyridine N-oxides with five-membered heterocycles

Wei Liu et al.

CHEMICAL COMMUNICATIONS (2014)

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Article Chemistry, Medicinal

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals

Edon Vitaku et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Organic

Rh(III)-catalyzed regioselective hydroarylation of alkynes via directed C-H functionalization of pyridines

Zhen-Chao Qian et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

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Article Chemistry, Organic

Rh(III)-Catalyzed Amide-Directed Cross-Dehydrogenative Heteroarylation of Pyridines

Yaping Shang et al.

ORGANIC LETTERS (2014)

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Article Chemistry, Organic

Iron-Catalyzed Arylation of Heterocycles via Directed C-H Bond Activation

John J. Sirois et al.

ORGANIC LETTERS (2014)

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Article Chemistry, Organic

C2-Arylation of Substituted Pyridine N-oxides with Heteroaryl Carboxylic Acids by Palladium-Catalyzed Decarboxylative Coupling

Rajendran Suresh et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2014)

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Article Chemistry, Multidisciplinary

Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates

Fenglin Dai et al.

CHEMICAL COMMUNICATIONS (2013)

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Article Plant Sciences

Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors from Morinda citrifolia (Noni) and Their Insulin Mimetic Activity

Phi-Hung Nguyen et al.

JOURNAL OF NATURAL PRODUCTS (2013)

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Article Chemistry, Organic

Copper-Catalyzed Direct Ortho-Alkylation of N-Iminopyridinium Ylides with N-Tosylhydrazones

Qing Xiao et al.

JOURNAL OF ORGANIC CHEMISTRY (2013)

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Article Chemistry, Multidisciplinary

Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides

Bin Xiao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Chemistry, Organic

Rhodium(III)-Catalyzed Oxidative Olefination of Pyridines and Quinolines: Multigram-Scale Synthesis of Naphthyridinones

Jun Zhou et al.

ORGANIC LETTERS (2013)

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Article Chemistry, Inorganic & Nuclear

Role of Mono-N-protected Amino Acid Ligands in Palladium(II)-Catalyzed Dehydrogenative Heck Reactions of Electron-Deficient (Hetero)arenes: Experimental and Computational Studies

Xuefeng Cong et al.

ORGANOMETALLICS (2013)

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Article Chemistry, Applied

Palladium-Catalyzed C-2 Selective C-H Olefination of Pyridines

Ping Wen et al.

ADVANCED SYNTHESIS & CATALYSIS (2012)

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Article Chemistry, Multidisciplinary

Ruthenium-Catalyzed C6-Propenylation Reactions of Substituted Pyridine Derivatives: Directed and Direct C-H Activation

Yogesh Goriya et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

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Article Chemistry, Multidisciplinary

Rollover Cyclometalation Pathway in Rhodium Catalysis: Dramatic NHC Effects in the C-H Bond Functionalization

Jaesung Kwak et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

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Review Chemistry, Multidisciplinary

Regio- and Chemoselective Metalation of Arenes and Heteroarenes Using Hindered Metal Amide Bases

Benjamin Haag et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Review Chemistry, Multidisciplinary

The asymmetric Heck and related reactions

Dennis Mc Cartney et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Article Chemistry, Organic

Synthesis of Quinolines via Rh(III)-Catalyzed Oxidative Annulation of Pyridines

Guoyong Song et al.

JOURNAL OF ORGANIC CHEMISTRY (2011)

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Article Chemistry, Multidisciplinary

Ligand-Promoted C-3 Selective C-H Olefination of Pyridines with Pd Catalysts

Mengchun Ye et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Chemistry, Multidisciplinary

Palladium-Catalyzed Regioselective Silaboration of Pyridines Leading to the Synthesis of Silylated Dihydropyridines

Kazuyuki Oshima et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Chemistry, Multidisciplinary

Rare-Earth-Catalyzed C-H Bond Addition of Pyridines to Olefins

Bing-Tao Guan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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