Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.

Automated summary

We have developed a robust catalyst system for the Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs), by optimizing the metal salt, reaction conditions, and ionic liquids. This system tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.