期刊
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/ajco.13968
关键词
cervical spine; dumbbell chordoma; misdiagnosis
类别
This study analyzed the clinical characteristics and outcomes of patients with primary dumbbell chordoma of the cervical spine and summarized the causes of misdiagnosis. The study found that primary dumbbell chordomas of the cervical spine can be easily misdiagnosed as neurogenic tumors, and preoperative CT-guided fine-needle aspiration puncture biopsy helps make an accurate diagnosis. Gross total excision with postoperative radiotherapy has been proven effective in reducing the recurrence rate.
AimThis study aimed to analyze the clinical characteristics and outcomes of patients with primary dumbbell chordoma of the cervical spine and to summarize the causes of misdiagnosis. MethodsThe clinical data of patients were retrospectively collected. The diagnostic process, surgical procedures, and outcomes were analyzed, then the difference was compared between dumbbell and non-dumbbell chordomas of the cervical spine. ResultsThis study included six patients with primary dumbbell chordoma (one male and five females) with a mean age of 32.2 +/- 24.5 years (range: 5-61 years). Five cases with no computed tomography (CT) examination before the first operation were misdiagnosed, and on magnetic resonance imaging (MRI), primary dumbbell chordoma showed the following specific features: extensive invasion of the surrounding soft tissues with an obscure boundary (>= 5 cm), intervertebral disc sparing, and hemorrhagic necrosis, furthermore, the CT features included atypical destructive vertebral lesions, minimal intralesional calcification, and neural foraminal enlargement. After comparison with non-dumbbell chordomas, it show statistical difference (p < 0.05) in terms of calcification, foramen enlargement, FNA, misdiagnosis rate but with different recurrent rate. ConclusionPrimary dumbbell chordomas of the cervical spine can easily be misdiagnosed as neurogenic tumors. Preoperative CT-guided fine-needle aspiration puncture biopsy helps make an accurate diagnosis. Gross total excision with postoperative radiotherapy has been proven effective in reducing the recurrence rate.
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