Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease

Article Clinical Neurology

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

Romit Bhattacharya et al.

Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke.

STROKE (2022)

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Article Cardiac & Cardiovascular Systems

Plasma Ceramide Levels Are Elevated in Patients With Early Coronary Atherosclerosis and Endothelial Dysfunction

Nadia Akhiyat et al.

Summary: The study showed that elevated plasma ceramide levels were associated with coronary endothelial dysfunction in early coronary atherosclerosis, suggesting that plasma ceramides may serve as potential biomarkers or therapeutic targets for early coronary atherosclerosis in humans.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

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Article Cardiac & Cardiovascular Systems

Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction

Ali Ahmad et al.

Summary: This study found that coronary microvascular function is inversely associated with filling pressures, particularly during exercise. Both types of coronary microvascular dysfunction are associated with higher filling pressures at peak exercise.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Article Cardiac & Cardiovascular Systems

Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease

Christopher S. Marnell et al.

Summary: Clonal hematopoiesis of indeterminate potential (CHIP) refers to clonal expansion of hematopoietic stem cells with leukemogenic mutations in individuals without hematologic malignancy. It is associated with a 0.5-1.0% risk of leukemia per year and a two-fold increase in cardiovascular risk. Mutations in specific genes are common in CHIP patients, and the condition is linked to various inflammatory diseases and prognosis of cardiovascular and other conditions.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Review Hematology

Coronary Microvascular Dysfunction

Shigeo Godo et al.

Summary: Accumulating evidence over the past few decades has shown that structural and functional abnormalities of coronary microvasculature are highly prevalent and associated with adverse clinical outcomes in patients with various cardiovascular diseases. CMD has been recognized as an important clinical entity, with potential mechanisms including enhanced coronary vasoconstrictive reactivity at the microvascular level.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction

Domingo A. Pascual-Figal et al.

Summary: This study found that clonal hematopoiesis mutations are common among HF patients with reduced LVEF and are associated with accelerated HF progression, regardless of whether the etiology is ischemic or nonischemic.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy

Allison C. Ostriker et al.

Summary: The study found that TET2 is suppressed in CAV and GA, likely mediated by IFN gamma. TET2 helps to protect VSMCs from apoptosis in the context of transplant vasculopathy or IFN gamma stimulation. Enhancing TET2 enzymatic activity with high-dose ascorbic acid reduces VSMC apoptosis and intimal thickening, suggesting that promoting TET2 activity in CAV may be an effective strategy for limiting CAV progression.

CIRCULATION (2021)

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Article Multidisciplinary Sciences

Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects

Susanne Gaul et al.

Summary: When extracellular NLRP3 inflammasome particles are internalized into human coronary artery smooth muscle cells, they induce pro-inflammatory and pro-atherogenic effects, representing a novel mechanism of cell-cell communication and perpetuation of inflammation in atherosclerosis. Therefore, extracellular NLRP3 inflammasomes could be used to improve the diagnosis of inflammatory diseases and develop new anti-inflammatory therapeutic strategies.

SCIENTIFIC REPORTS (2021)

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Review Cardiac & Cardiovascular Systems

Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

Siddhartha Jaiswal et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

Alexander G. Bick et al.

CIRCULATION (2020)

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Review Cardiac & Cardiovascular Systems

Association of Isolated Coronary Microvascular Dysfunction With Mortality and Major Adverse Cardiac Events: A Systematic Review and Meta-Analysis of Aggregate Data

Mark A. Gdowski et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Multidisciplinary Sciences

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

Tarek H. Mouhieddine et al.

NATURE COMMUNICATIONS (2020)

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Article Cardiac & Cardiovascular Systems

Coronary Microvascular Endothelial Dysfunction in Patients With Angina and Nonobstructive Coronary Artery Disease Is Associated With Elevated Serum Homocysteine Levels

Ali Ahmad et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Review Medicine, General & Internal

Coronary Microvascular Dysfunction

Federico Vancheri et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Global Coronary Flow Reserve Measured During Stress Cardiac Magnetic Resonance Imaging Is an Independent Predictor of Adverse Cardiovascular Events

Raksha Indorkar et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Cardiac & Cardiovascular Systems

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic lschemic Heart Failure

Lena Dorsheimer et al.

JAMA CARDIOLOGY (2019)

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Editorial Material Cardiac & Cardiovascular Systems

CHIPping Away at the Pathogenesis of Heart Failure

Peter Libby et al.

JAMA CARDIOLOGY (2019)

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Review Biochemistry & Molecular Biology

TET2: A Novel Epigenetic Regulator and Potential Intervention Target for Atherosclerosis

Yami Liu et al.

DNA AND CELL BIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

Soichi Sano et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Editorial Material Cardiac & Cardiovascular Systems

CHIP (Clonal Hematopoiesis of Indeterminate Potential): Potent and Newly Recognized Contributor to Cardiovascular Risk

Peter Libby et al.

CIRCULATION (2018)

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Article Biochemistry & Molecular Biology

Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?

Fei Li et al.

GENES & DISEASES (2018)

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Review Cardiac & Cardiovascular Systems

Interleukin-1 Beta as a Target for Atherosclerosis Therapy Biological Basis of CANTOS and Beyond

Peter Libby

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Medicine, General & Internal

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

S. Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Multidisciplinary Sciences

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Jose J. Fuster et al.

SCIENCE (2017)

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Article Multidisciplinary Sciences

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Andrew L. Young et al.

NATURE COMMUNICATIONS (2016)

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Article Hematology

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

David P. Steensma et al.

BLOOD (2015)

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Article Peripheral Vascular Disease

Endothelial dysfunction is associated with the severity of cerebral small vessel disease

Tomohisa Nezu et al.

HYPERTENSION RESEARCH (2015)

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Article Cardiac & Cardiovascular Systems

Prevalence of Coronary Microvascular Dysfunction Among Patients With Chest Pain and Nonobstructive Coronary Artery Disease

Jaskanwal D. Sara et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2015)

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Article Medicine, General & Internal

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Cardiac & Cardiovascular Systems

Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

Renjing Liu et al.

CIRCULATION (2013)

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Review Cardiac & Cardiovascular Systems

Coronary microvascular dysfunction in the clinical setting: from mystery to reality

Joerg Herrmann et al.

EUROPEAN HEART JOURNAL (2012)

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Article Cardiac & Cardiovascular Systems

Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease

Alejandro Recio-Mayoral et al.

EUROPEAN HEART JOURNAL (2009)

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Review Medicine, General & Internal

Medical progress - Coronary microvascular dysfunction

Paolo G. Camici et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Article Cardiac & Cardiovascular Systems

The endothelium: Dysfunction and beyond

J Herrmann et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2001)

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Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease

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