Unveiling Intriguing Links Between Limb Ischemia, Systemic Inflammation, and Progressive Atherosclerosis: A Tangled and Interconnected Web

Article Hematology

Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis

Emilie Coppin et al.

Summary: Peripheral artery disease is associated with increased inflammation and inflammatory cell production, but the underlying mechanisms are not well understood. This study found that patients with peripheral artery disease and mice with hind limb ischemia exhibited elevated leukocyte numbers. Further analysis revealed migration of hematopoietic stem and progenitor cells (HSPCs) from the osteoblastic niche to the vascular niche, along with enhanced proliferation and differentiation. Inhibition of IL-1 and IL-3 receptors resulted in suppressed HSPC proliferation, reduced leukocyte production, and improved atherosclerosis.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2023)

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Article Surgery

Characterizing patient-reported claudication treatment goals to support patient-centered treatment selection and measurement strategies

Chloe A. Powell et al.

Summary: This study evaluated the patient-reported treatment goals and expectations among patients with claudication and found that patient-defined treatment goals may not be achievable or aligned with guidelines or clinical outcomes. The primary treatment goals were increased walking distance or duration, performing specific activities or tasks, and increased walking speed. These treatment goals were associated with patient characteristics and PAD-specific patient-reported outcomes.

JOURNAL OF VASCULAR SURGERY (2023)

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Review Cardiac & Cardiovascular Systems

Update on the pathophysiology and medical treatment of peripheral artery disease

Jonathan Golledge

Summary: In this review, the author summarizes the epidemiology, presentation, outcomes, pathophysiology, and current treatment of peripheral artery disease (PAD), and outlines ongoing research into new medical treatments. PAD is a growing global public health problem with high and rising prevalence and adverse outcomes.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Bone marrow activation in response to metabolic syndrome and early atherosclerosis

Ana Devesa et al.

Summary: Experimental studies suggest that increased bone marrow activity is associated with cardiovascular risk factors, inflammation, and atherosclerosis. This study found that bone marrow activation is associated with metabolic syndrome and early atherosclerosis, even in the absence of systemic inflammation.

EUROPEAN HEART JOURNAL (2022)

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Article Surgery

The cost-effectiveness of intensive low-density lipoprotein cholesterol lowering in people with peripheral artery disease

Domenico R. Nastasi et al.

Summary: The study estimated the benefit and cost-effectiveness of administering PCSK9 inhibitors to patients with peripheral artery disease. The findings suggest that intensive lowering of LDL-C can significantly reduce the risk of MACE and MALE, especially in patients with CLTI.

JOURNAL OF VASCULAR SURGERY (2021)

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Article Surgery