☆ 4.7 Article

Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures

ARCHIVES OF TOXICOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Pharmacology & Pharmacy

3D human liver spheroids for translational pharmacology and toxicology

Magnus Ingelman-Sundberg et al.

Summary: Drug development is a challenging and failure-prone process, with liver toxicity being a major cause of safety failures. The current preclinical systems for compound selection are inadequate, necessitating the development of new strategies to increase clinical success rates. Human liver spheroids are becoming increasingly utilized for various analyses and drug development, showing promise as a new standard in translational pharmacology and toxicology.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gene Expression over Time during Cell Transformation Due to Non-Genotoxic Carcinogen Treatment of Bhas 42 Cells

Kiyomi Ohmori et al.

Summary: The Bhas 42 cell transformation assay is a useful tool for detecting the cell-transformation potential of tumor-promoting compounds. It allows for the direct detection of chemical-induced cell transformation, making it valuable for studying the mechanisms involved.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Analyses of Transcriptomics Cell Signalling for Pre-Screening Applications in the Integrated Approach for Testing and Assessment of Non-Genotoxic Carcinogens

Yusuke Oku et al.

Summary: With the recent rapid advancement of methodological tools, the mechanistic understanding of biological processes leading to carcinogenesis is expanding. New methodologies such as transcriptomics can provide information on non-genotoxic mechanisms of chemical carcinogens for regulatory applications. The OECD expert group is reviewing assays to be integrated into the Integrated Approach to the Testing and Assessment (IATA) of Non-Genotoxic Carcinogens (NGTxC), focusing on pre-screening gene expression changes associated with phenotypic alterations that underlie carcinogenic processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Environmental Sciences

Sorafenib reduces steatosis-induced fibrogenesis in a human3Dco-culture model of non-alcoholic fatty liver disease

Guilherme Ribeiro Romualdo et al.

Summary: NAFLD affects approximately 25% of the global population, with NASH presenting a more progressive form of the disease. Research has shown that sorafenib exhibits antifibrotic effects in a 3D in vitro model, indicating its potential clinical use for the treatment of NAFLD/NASH patients.

ENVIRONMENTAL TOXICOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Carcinogenesis: Failure of resolution of inflammation

Anna Fishbein et al.

Summary: Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a key characteristic of carcinogens. The failure of resolution of inflammation in cancer is being understood. Eicosanoids play a critical role in regulating inflammation and its resolution, while non-genotoxic mechanisms such as inflammation and oxidative stress promote genotoxicity and contribute to carcinogenesis.

PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Review Toxicology

Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop

Susan P. Felter et al.

Summary: The workshop discussed challenges related to assessing chemical carcinogenicity, focusing on problem formulation, modes-of-action, and dose-response assessment, and proposed methods to address these issues. Scientific limitations of traditional rodent chronic bioassays were acknowledged, as well as knowledge gaps that need to be addressed for the further development and application of new approach methodologies.

CRITICAL REVIEWS IN TOXICOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals

Vania Vilas-Boas et al.

Summary: This study investigated the cholestatic potential of non-pharmaceutical chemicals using primary human hepatocytes cultured in 3D spheroids. The results showed that short exposures to cyclosporine-A consistently decreased the cholestatic index, bosentan exhibited hepatotoxicity, and triclosan markedly deregulated genes involved in different types of hepatotoxicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Connexin-Based Channel Activity Is Not Specifically Altered by Hepatocarcinogenic Chemicals

Kaat Leroy et al.

Summary: The study found that both genotoxic and non-genotoxic carcinogenic compounds negatively affect connexin32 expression, but no specific effects related to chemical type were observed at the gap junction or connexin hemichannel functionality level.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Oncology

Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro

Zohre Zibaei et al.

Summary: Gemini-curcumin nanoparticles exhibited tumoricidal effects on 3D spheroid HT-29 cells, disrupting spheroids, reducing cell density, inhibiting cell migration, and preventing epithelial-mesenchymal transition through suppression of specific genes.

CANCER NANOTECHNOLOGY (2021)

添加到收藏夹

Article Environmental Sciences

Hepatocellular carcinoma (HepG2/C3A) cell-based 3D model for genotoxicity testing of chemicals

Martina Stampar et al.

Summary: The study developed a method for genotoxicity testing using 21-day old HepG2/C3A spheroids, which showed high sensitivity and promising potential for evaluating genotoxic activities and environmental studies.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach

Andres Tabernilla et al.

Summary: The paper proposes a rationalized tiered in vitro testing strategy to detect liver toxicity triggered by chemicals, with the first tier focused on general cytotoxicity assessment and the second tier aimed at identifying liver-specific toxicity. It provides an overview of commonly used in vitro assays and discusses the advantages, disadvantages, and practical considerations of each assay.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Toxicology

Threshold of Toxicological Concern-An Update for Non-Genotoxic Carcinogens

Monika Batke et al.

Summary: The TTC concept is utilized for organic compounds to establish exposure threshold based on chemical structure; Cramer classes are shown to be effective in providing adequate protection for non-genotoxic carcinogens.

FRONTIERS IN TOXICOLOGY (2021)

添加到收藏夹

Review Toxicology

Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop

Susan P. Felter et al.

CRITICAL REVIEWS IN TOXICOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron

Mustafa Cengiz et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

添加到收藏夹

Article Toxicology

Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Miriam N. Jacobs et al.

ARCHIVES OF TOXICOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

Natalia Siwecka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

Yuning Lin et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Revealing Protein Aggregates under Thapsigargin-Induced ER Stress Using an ER-Targeted Thioflavin

Peter Verwilst et al.

ACS SENSORS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids

Mohammad Azharuddin et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Toxicology

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

Gamze Ates et al.

ARCHIVES OF TOXICOLOGY (2018)

添加到收藏夹

Review Toxicology

Thresholds of Genotoxic and Non-Genotoxic Carcinogens

Takehiko Nohmi

TOXICOLOGICAL RESEARCH (2018)

添加到收藏夹

Article Toxicology

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells

Eleanor C. Wilde et al.

ARCHIVES OF TOXICOLOGY (2018)

添加到收藏夹

Article Food Science & Technology

The current limitations of in vitro genotoxicity testing and their relevance to the in vivo situation

Fabrice Nesslany

FOOD AND CHEMICAL TOXICOLOGY (2017)

添加到收藏夹

Article Toxicology

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Raffaella Corvi et al.

TOXICOLOGY IN VITRO (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests

David Kirkland et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

Michele Zanoni et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Toxicology

3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies

Daniel Mueller et al.

TOXICOLOGY IN VITRO (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T

Daniel R. Beriault et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

添加到收藏夹

Article Oncology

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

Tatyana Y. Doktorova et al.

CARCINOGENESIS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Distinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis

Seul Ji Lee et al.

SCIENTIFIC REPORTS (2013)

添加到收藏夹

Article Toxicology

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

Tatyana Y. Doktorova et al.

ARCHIVES OF TOXICOLOGY (2012)

添加到收藏夹

Article Toxicology

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data

Tatyana Y. Doktorova et al.

ARCHIVES OF TOXICOLOGY (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR

Takashi Watanabe et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats

Premila Abraham et al.

REDOX REPORT (2011)

添加到收藏夹

Review Food Science & Technology

Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens

Alan R. Boobis et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2009)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

Lya G. Hernandez et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2009)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

Mathieu Vinken et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.