☆ 4.7 Article

Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity

ARCHIVES OF TOXICOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Epithelial morphogenesis in organoids

Byung Ho Lee et al.

Summary: Epithelial organoids can mimic morphogenetic processes in vivo, such as lumen and multilayer formation, folding, branching, delamination, and elongation. This article elaborates on the signaling molecules controlling morphogenesis, including their emergence as signaling centers in the organoids. It also discusses how mechanical cues and environmental material properties influence organoid shape.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

添加到收藏夹

Article Toxicology

Crypt and Villus Transcriptomic Responses in Mouse Small Intestine Following Oral Exposure to Hexavalent Chromium

Grace A. Chappell et al.

Summary: Oral exposure to hexavalent chromium induces tumors in the mouse duodenum. Transcriptional analyses were conducted separately on crypt and villus tissue, revealing a significant increase in mitotic cell cycle genes in the crypt compartment and minimal evidence of DNA damage response. These results provide insight into the mechanism of Cr(VI)-induced small intestine tumors in mice.

TOXICOLOGICAL SCIENCES (2022)

添加到收藏夹

Review Genetics & Heredity

Organoids for toxicology and genetic toxicology: applications with drugs and prospects for environmental carcinogenesis

Angela L. Caipa Garcia et al.

Summary: Advances in three-dimensional cell culture technology have allowed the development of organoids, which have proven useful for studying organ development, disease, toxicology, and drug screening. Organoids derived from pluripotent stem cells have greater complexity compared to those derived from adult stem cells. These organoids have been beneficial for pre-clinical testing of personalized treatments and in developing large toxicity and efficacy screens. They have also shown promise in environmental and genetic toxicology studies, providing responses similar to those observed in primary tissues and in vivo models.

MUTAGENESIS (2022)

添加到收藏夹

Article Environmental Sciences

Associations of multiple metals with lung function in welders by four statistical models

Luli Wu et al.

Summary: Exposure to heavy metals is correlated with decreased lung function in workers. This study demonstrates the effects of metal mixtures on lung function and identifies lead, cadmium, nickel, and strontium as crucial elements. The findings highlight the importance of protecting workers' environmental health.

CHEMOSPHERE (2022)

添加到收藏夹

Review Cell Biology

Cell fate specification and differentiation in the adult mammalian intestine

Joep Beumer et al.

Summary: Intestinal stem cells fuel tissue renewal, with the epithelium absorbing nutrients while acting as a barrier, lineage plasticity and niche signals enable efficient tissue repair, new insights from single-cell transcriptomics and organoid models reveal the importance of cell lineage plasticity and niche signals for tissue repair.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Organoid-based modeling of intestinal development, regeneration, and repair

Joep Sprangers et al.

Summary: This review discusses the regenerative response of intestinal epithelial cells to injury, as well as how the Wnt and YAP signaling pathways control intestinal repair. It also emphasizes how organoid-based applications have contributed to unraveling the key mechanisms behind these developmental and regenerative events.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Organoids in image-based phenotypic chemical screens

Ilya Lukonin et al.

Summary: Image-based phenotypic screening using organoids offers great potential but also unique challenges, requiring careful experimental design and process optimization. Advances in high-throughput microscopy and three-dimensional image analysis algorithms are crucial for robust chemical screening of organoids.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Letter Biotechnology & Applied Microbiology

The Organoid Cell Atlas

Christoph Bock et al.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Stem Cells for Next Level Toxicity Testing in the 21st Century

Ellen Fritsche et al.

Summary: The call for a paradigm change in toxicology initiated by the United States National Research Council in 2007 highlights the importance of human-relevant alternative methods for toxicological hazard assessment. This review article discusses critical organs such as skin, brain, and lungs in terms of their functions in health and disease, emphasizing the need for more complex organotypic models. Innovative technologies like organs-on-a-chip and genome editing are paving the way for a shift in toxicological paradigm towards more advanced and human-specific approaches.

SMALL (2021)

添加到收藏夹

Article Oncology

Imaging-Based Machine Learning Analysis of Patient-Derived Tumor Organoid Drug Response

Erin R. Spiller et al.

Summary: Three-quarters of compounds fail to make it to market in clinical trials, highlighting the need for better screening methods. Patient-derived organoids are seen as a promising 3D preclinical model system with challenges in assessing drug efficacy.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Rebuttal to: In Vivo Studies Should Take Priority When Defining Mechanisms of Intestinal Crypt Morphogenesis

Shinya Sugimoto et al.

Cellular and Molecular Gastroenterology and Hepatology (2021)

添加到收藏夹

Article Cell Biology

Epigenetic Drifts during Long-Term Intestinal Organoid Culture

Torsten Thalheim et al.

Summary: Organoids derived from mice with mismatch repair-deficiency underwent profound epigenetic changes during long-term culture, including activation of previously unmodified genes and loss of bivalent gene repression. These changes led to broad transcriptional alterations and disrupted metabolic adaptation processes, particularly in MMR-deficient mice, suggesting a link between epigenetic drift and disturbances in normal cellular function.

CELLS (2021)

添加到收藏夹

Review Toxicology

Toxicity testing in the 21st century: progress in the past decade and future perspectives

D. Krewski et al.

ARCHIVES OF TOXICOLOGY (2020)

添加到收藏夹

Article Engineering, Environmental

Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine

Shuang Xie et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Phenotypic landscape of intestinal organoid regeneration

Ilya Lukonin et al.

NATURE (2020)

添加到收藏夹

Article Biochemical Research Methods

Establishment of patient-derived cancer organoids for drug-screening applications

Else Driehuis et al.

NATURE PROTOCOLS (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Tissue Responses to Shiga Toxin in Human Intestinel Organoids

Suman Pradhan et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Self-organization and symmetry breaking in intestinal organoid development

Denise Serra et al.

NATURE (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Hormesis: The dose response for the 21st century: The future has arrived

Evgenios Agathokleous et al.

TOXICOLOGY (2019)

添加到收藏夹

Review Toxicology

Review of high-content screening applications in toxicology

Shuaizhang Li et al.

ARCHIVES OF TOXICOLOGY (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Development of organoid-based drug metabolism model

Enoch Park et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

添加到收藏夹

Article Engineering, Environmental

Toward Capturing the Exposome: Exposure Biomarker Variability and Coexposure Patterns in the Shared Environment

Ming Kei Chung et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

添加到收藏夹

Article Cell Biology

A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance

Yehua Li et al.

CELL DISCOVERY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Essential ole of IFN-γ in T cell-associated intestinal inflammation

Yoshihiro Eriguchi et al.

JCI INSIGHT (2018)

添加到收藏夹

Article Cell & Tissue Engineering

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling

Jorge O. Munera et al.

CELL STEM CELL (2017)

添加到收藏夹

Article Cell Biology

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy

T. Grabinger et al.

CELL DEATH & DISEASE (2014)

添加到收藏夹

Review Multidisciplinary Sciences

Cytosystems dynamics in self-organization of tissue architecture

Yoshiki Sasai

NATURE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Jason R. Spence et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato et al.

NATURE (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

Akifumi Ootani et al.

NATURE MEDICINE (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker et al.

NATURE (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.