Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

Introduction: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). Methods: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, for the analysis of the effect of PEAR1 rs12041331 on HPR and RIS. Results: The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was associated with HPR. This link was not observed for RIS. Conclusions: The PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR. The correlation between PEAR1 and RIS needs to be studied further.

Automated summary

The aim of this study was to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, and the effect of PEAR1 rs12041331 on HPR and RIS was analyzed. The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was correlated with HPR but not with RIS. The study suggests that PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR, and further research is needed to investigate the correlation between PEAR1 and RIS.