期刊
ARCHIVES OF GERONTOLOGY AND GERIATRICS
卷 107, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2022.104895
关键词
Aging; Oxidative stress; Inflammation; Resveratrol
In this study, we investigated the antioxidant and anti-inflammatory effects of resveratrol (RSV) on human mononuclear cells (PBMCs) from middle-aged and elderly donors. Our findings suggest that RSV has a greater impact on reducing oxidative stress and inflammation in middle-aged individuals compared to the elderly.
In the elderly, there is an increase in oxidative and inflammatory activity. Resveratrol (RSV) is a polyphenol that has several proven biological activities, such as antioxidant and anti-inflammatory. Thus, the aim of our study was to verify the possible antioxidant and anti-inflammatory effects of RSV on human mononuclear cells (PBMCs) from donors aged between 40 and 59 and 60-80 years old. For this, 6-8 patients were selected by age group. Cells were isolated and divided into 4 groups: Control (C), RSV only, H2O2 (to induce an oxidizing environment - C+) and H2O2+RSV. The quantification of reactive nitrogen species (NO and ONOO-), as well as pro and anti-inflammatory cytokines (TNF alpha, IL-6 and IL-10) was performed. Pearson's correlation and com-parison between groups were performed (p<0.05). Our results showed a greater role of RSV in the middle-aged compared to the elderly group, in relation to the balance of NO/ONOO-and the levels of cytokines IL-6 and TNF alpha. It was also possible to observe an improvement in the anti-inflammatory profile in both age groups, but more effective in the cells in the middle-aged group. Thus, we could observe that RSV has better activity in the reduction of important biomarkers of oxidation and inflammation.
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