期刊
ARCHIV DER PHARMAZIE
卷 356, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.202200664
关键词
anticancer agents; dihydropyrimidinones (DHPMs); structure-activity relationship; synthesis
Cancer is a serious disease without a sustainable solution. The search for better cancer treatments has led to the development and study of new scaffolds, such as Dihydropyrimidinones (DHPMs), which are known for their versatile range of biological activities. This review summarizes the structure-activity relationship of DHPMs as potential anticancer agents, including their synthesis, mechanism of action, and the interlinked mechanisms leading to their anticancer activity.
Cancer is a serious disease that has been around for a long time but currently has no sustainable solution. Several medications currently available offer an opportunity for the manifestation of cancer treatment; however, the search for better has led to the development and study of a variety of new scaffolds. Dihydropyrimidinones (DHPMs) are a privileged scaffold, prominent for their versatile range of biological activities. In recent years, the anticancer potential of these unsaturated pyrimidine ring systems has been traversed, along with their synthesis methods and the interlinked mechanisms leading to the anticancer activity. This review summarizes the structure-activity relationship of DHPMs as potential anticancer agents. This study is a short review of their synthesis, mechanism of action, and structure-activity relationships (SARs) that are answerable for the anticancer activity of DHPMs and have been thoroughly researched and assessed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据