期刊
CELLULOSE
卷 22, 期 4, 页码 2141-2148出版社
SPRINGER
DOI: 10.1007/s10570-015-0683-2
关键词
Bacterial cellulose; Poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate); Composites; Biocompatibility; Biomedical; Tissue engineering
资金
- Basic Science Research Program through the National Research Foundation (NRF) - Ministry of Education, Science and Technology, Korea [NRF-2014-R1A1A2055756]
- BK21 plus, Korea [21A.2013-1800001]
This study explores the biocompatible behavior of bacterial cellulose (BC) composites with the highly conductive poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (PEDOT:PSS). To synthesize this novel composite, we utilized an ex situ penetration method, whereby never-dried BC sheets were incubated with aqueous PEDOT: PSS solution. The resulting composite films were characterized using several analytical tools. Field-emission scanning electron microscopy illustrated the impregnation of PEDOT: PSS into the BC matrix, while the uniform dispersion of PEDOT: PSS in the composites was confirmed with energy-dispersive X-ray spectroscopy. The conductivity of the PEDOT: PSS incorporated BC was 7.3 9 10(-2) +/- 0.021 S/cm with 29.37 +/- 2.13 weight percentage (wt%) of PEDOT: PSS. The biocompatibility of the BC-PEDOT: PSS film was tested against animal fibroblast cells. The composites showed excellent cell adhesion and proliferation. The animal cells showed filopodia formation and interconnectivity during 3 days of incubation. The cytotoxicity of the BC-PEDOT:PSS film was also assayed, confirming the non-toxic nature of this composite. Taken together, our results demonstrate that this novel biocompatible BC-PEDOT:PSS composite could potentially be used for biomedical applications, particularly in the biosensors, drug delivery devices, neural implants, and tissue engineering fields.
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