Copper triazole complex supported on Fe3O4@SiO2 nanoparticles as eco-friendly nanocatalysts in solvent-free Biginelli reaction

In this work, a new heterogeneous catalyst based on 1,2,3-triazole complex of copper supported on core-shell Fe3O4@SiO2 nanoparticles was designed and characterized by using several methods such as infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetry analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDX). The magnetic nanocatalyst was successfully employed for the synthesis of different functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones by a one-pot multicomponent condensation reaction under solvent-free conditions. Among the advantages of the developed catalytic protocol are the high yields, short reaction times, ecofriendly, easy workup and purification conditions.

Automated summary

A new heterogeneous catalyst based on copper complex of 1,2,3-triazole supported on Fe3O4@SiO2 nanoparticles was designed and characterized. The catalyst showed high catalytic activity in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. The advantages of this catalytic system include high yields, short reaction times, eco-friendliness, and easy workup and purification conditions.