☆ 4.7 Article

Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer

APOPTOSIS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Oncology

Systemic Therapy in Thyroid Cancer

Amit Kumar Agrawal et al.

Summary: Thyroid cancer treatment involves surgery and radioactive iodine therapy, with systemic therapy needed for refractory cases. Targeting oncogenic drivers in thyroid cancer cells has shown effectiveness, but challenges such as high treatment cost and lack of testing for driver mutations still exist. Further research is needed to identify oncogenic targets and corresponding agents in thyroid cancers.

INDIAN JOURNAL OF SURGICAL ONCOLOGY (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Sex Differences in Differentiated Thyroid Cancer

Leila Shobab et al.

Summary: Greater understanding of the molecular mechanisms underlying sex differences in TC pathogenesis could provide insights into the development of sex-specific, targeted, and effective strategies for prevention, diagnosis, and management.

THYROID (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Overview of the 2022 WHO Classification of Thyroid Neoplasms

Zubair W. Baloch et al.

Summary: This review summarizes the changes in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors that relate to the thyroid gland. The new classification provides a more detailed understanding of the different types of thyroid tumors based on their cell of origin, pathologic features, molecular profiles, and biological behavior. It also introduces new categories, such as thyroid follicular nodular disease, non-invasive follicular thyroid neoplasm with papillary-like nuclear features, and high-grade differentiated thyroid carcinomas. The classification emphasizes the importance of biomarkers in diagnosis and prognosis.

ENDOCRINE PATHOLOGY (2022)

添加到收藏夹

Article Oncology

OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer

Mila Gugnoni et al.

Summary: The study revealed the impaired expression of OVOL2 in ATC and its transcriptional inhibition of the RHO GTPase pathway, leading to the suppression of EMT, cytoskeleton dynamics, and mitosis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance

Yumei Huang et al.

Summary: The study reveals the important role of UBE2O in radioresistance of lung cancer by promoting Mxi1 ubiquitination and degradation, facilitating tumor progression. Additionally, UBE2O is found to be overexpressed and negatively correlated with Mxi1 protein levels in lung cancer tissues.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Sex Bias in Differentiated Thyroid Cancer

Valentine Suteau et al.

Summary: Differentiated thyroid cancers are more common in women, possibly due to differences in patient behavior and thyroid investigations, as well as the potential impact of sex hormones. The reasons behind the poorer prognosis of thyroid cancer in male patients remain poorly explained.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Oncology

POTEE promotes colorectal carcinoma progression via activating the Rac1/Cdc42 pathway

Qiong Xu et al.

EXPERIMENTAL CELL RESEARCH (2020)

添加到收藏夹

Article Cell Biology

UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop

Xu Liu et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Global trends in thyroid cancer incidence and the impact of overdiagnosis

Mengmeng Li et al.

Lancet Diabetes & Endocrinology (2020)

添加到收藏夹

Article Oncology

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

Qiang Tang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Poorly Differentiated Carcinoma of the Thyroid Gland: Current Status and Future Prospects

Tihana Ibrahimpasic et al.

THYROID (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset

Kifayat Ullah et al.

FEBS JOURNAL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell Migration

Jinyang Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1

Suping Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

添加到收藏夹

Article Oncology

The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

Yujia Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Plekhg4 Is a Novel Dbl Family Guanine Nucleotide Exchange Factor Protein for Rho Family GTPases

Meghana Gupta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Rho GTPases in cancer cell biology

Francisco M. Vega et al.

FEBS LETTERS (2008)

添加到收藏夹

Review Oncology

Pathogenetic mechanisms in thyroid follicular-cell neoplasia

T Kondo et al.

NATURE REVIEWS CANCER (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.