☆ 4.7 Article

Cancer Resistance Is Mediated by the Upregulation of Several Anti-Apoptotic Gene Products via the Inducible Nitric Oxide Synthase/Nitric Oxide Pathway: Therapeutic Implications

ANTIOXIDANTS & REDOX SIGNALING (2023)

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BCL-2 family isoforms in apoptosis and cancer

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CELL DEATH & DISEASE (2019)

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Cell death: a review of the major forms of apoptosis, necrosis and autophagy

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CELL BIOLOGY INTERNATIONAL (2019)

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Review Biochemistry & Molecular Biology

The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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The Structural Biology of Bcl-xL

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Increased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia

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ONCOTARGETS AND THERAPY (2019)

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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

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CELL DEATH & DISEASE (2019)

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Prognostic Value of Inducible Nitric Oxide Synthase (iNOS) in Human Cancer: A Systematic Review and Meta-Analysis

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BIOMED RESEARCH INTERNATIONAL (2019)

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Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients

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JOURNAL OF ONCOLOGY (2019)

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TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

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Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells

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CANCER LETTERS (2019)

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Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer

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DIAGNOSTIC PATHOLOGY (2019)

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Current overview on the clinical update of Bcl-2 anti-apoptotic inhibitors for cancer therapy

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EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics

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BIOCHEMICAL PHARMACOLOGY (2019)

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Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

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Therapeutic Inducers of Apoptosis in Ovarian Cancer

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iNOS Interacts with Autophagy Receptor p62 and is Degraded by Autophagy in Macrophages

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S-Nitrosylation: An Emerging Paradigm of Redox Signaling

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Nitric oxide inhibits autophagy and promotes apoptosis in hepatocellular carcinoma

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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

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IFN and TNF synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide

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B7-H3 Induces Ovarian Cancer Drugs Resistance Through An PI3K/AKT/BCL-2 Signaling Pathway

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CURRENT OPINION IN PHYSIOLOGY (2019)

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Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

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Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

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C-MYC and BCL-2 mediate YAP-regulated tumorigenesis in OSCC

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S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death

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DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling

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MCL-1 is a prognostic indicator and drug target in breast cancer

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Targeting BCL-2 regulated apoptosis in cancer

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Pharmacological Inhibition of p38 MAPK by SB203580 Increases Resistance to Carboplatin in A2780cp Cells and Promotes Growth in Primary Ovarian Cancer Cells

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Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma

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Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

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Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?

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Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression

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Viewing BCL2 and cell death control from an evolutionary perspective

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BCL-2 family proteins: changing partners in the dance towards death

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Nitric oxide prevents H2O2-induced apoptosis in SK-N-MC human neuroblastoma cells

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Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis

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Nitric Oxide Donor-Based Cancer Therapy: Advances and Prospects

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Epigenetics: The third pillar of nitric oxide signaling

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BCL-XL overexpression promotes tumor progression-associated properties

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Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells

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MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease

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Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways

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Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo

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Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

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CELL DEATH AND DIFFERENTIATION (2017)

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Attacking cancer's Achilles heel: antagonism of antiapoptotic BCL-2 family members

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Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo

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Gasotransmitters in cancer: from pathophysiology to experimental therapy

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Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade

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Survivin: a unique target for tumor therapy

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Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells

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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Nitric oxide, the new architect of epigenetic landscapes

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NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2016)

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Bcl-xL is an oncogenic driver in colorectal cancer

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Bcl-xL promotes metastasis independent of its anti-apoptotic activity

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Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer

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ONCOTARGET (2016)

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Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats

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SCIENTIFIC REPORTS (2016)

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S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function

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APOPTOSIS (2015)

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BIOCHEMISTRY-MOSCOW (2015)

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Mapping the Pathways of Resistance to Targeted Therapies

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Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications

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P53-dependent miRNAs mediate nitric oxide-induced apoptosis in colonic carcinogenesis

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FREE RADICAL BIOLOGY AND MEDICINE (2015)

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Survivin: A molecular biomarker in cancer

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INDIAN JOURNAL OF MEDICAL RESEARCH (2015)

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Article Cell Biology

Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane

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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

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Editorial Material Oncology

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene

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Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells

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ONCOLOGY REPORTS (2015)

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Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis

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WORLD JOURNAL OF SURGICAL ONCOLOGY (2015)

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Article Biotechnology & Applied Microbiology

The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma

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BIOMED RESEARCH INTERNATIONAL (2015)

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Editorial Material Oncology

The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene

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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Review Biochemistry & Molecular Biology

S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer

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REDOX BIOLOGY (2015)

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STAT3 Regulation By S-Nitrosylation: Implication In Cancer

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Redox Biology (2015)

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BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma

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BLOOD (2015)

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Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer

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BREAST CANCER RESEARCH (2015)

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Article Oncology

3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway

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ANTI-CANCER DRUGS (2014)

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Article Biochemistry & Molecular Biology

STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease

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ANTIOXIDANTS & REDOX SIGNALING (2014)

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Arctigenin Promotes Apoptosis in Ovarian Cancer Cells via the iNOS/NO/STAT3/Survivin Signalling

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BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

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MCL-1 dependency of cisplatin-resistant cancer cells

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BIOCHEMICAL PHARMACOLOGY (2014)

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Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP

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BIOMEDICINE & PHARMACOTHERAPY (2014)

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Article Biochemistry & Molecular Biology

IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3

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CELL DEATH AND DIFFERENTIATION (2014)

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Upregulation of Cytoskeleton Protein and Extracellular Matrix Protein Induced by Stromal-Derived Nitric Oxide Promotes Lung Cancer Invasion and Metastasis

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CURRENT MOLECULAR MEDICINE (2014)

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Article Biochemistry & Molecular Biology

Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms

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FEBS JOURNAL (2014)

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Article Biochemistry & Molecular Biology

Mitochondria: FKBP38 and mitochondrial degradation

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

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Association of polymorphisms in iNOS and NQO1 with bladder cancer risk in cigarette smokers

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JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2014)

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Nitric oxide mediates cell aggregation and mesenchymal to epithelial transition in anoikis-resistant lung cancer cells

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MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription

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microRNA-200c downregulates XIAP expression to suppress proliferation and promote apoptosis of triple-negative breast cancer cells

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Review Oncology

Targeting the apoptosis pathway in hematologic malignancies

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LEUKEMIA & LYMPHOMA (2014)

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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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iNOS expression and NO production contribute to the direct effects of BCG on urothelial carcinoma cell biology

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UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2014)

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Review Physiology

Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications

Daniela Salvemini et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

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Review Biochemistry & Molecular Biology

Nitrosothiols in the Immune System: Signaling and Protection

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ANTIOXIDANTS & REDOX SIGNALING (2013)

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Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

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BMC CELL BIOLOGY (2013)

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Review Oncology

Clinico-pathologic relevance of Survivin splice variant expression in cancer

Rosalia de Necochea-Campion et al.

CANCER LETTERS (2013)

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Review Oncology

Targeting c-FLIP in cancer

Sarah Shirley et al.

CANCER LETTERS (2013)

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Review Oncology

Anti-apoptotic proteins on guard of melanoma cell survival

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CANCER LETTERS (2013)

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Targeting the Bcl-2 family for cancer therapy

Shibu Thomas et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2013)

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Cytoprotective Signaling Associated with Nitric Oxide Upregulation in Tumor Cells Subjected to Photodynamic Therapy-like Oxidative Stress

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FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Article Immunology

Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling

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Article Oncology

miR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin

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MOLECULAR MEDICINE REPORTS (2013)

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Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL

Marco A. Hernandez-Luna et al.

LEUKEMIA & LYMPHOMA (2013)

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Article Biochemistry & Molecular Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

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NATURE MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo. YY1 and BclXL are overexpressed in prostate cancer

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NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

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Article Biochemistry & Molecular Biology

MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R

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ONCOGENE (2013)

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MiR-26a Inhibits Proliferation and Migration of Breast Cancer through Repression of MCL-1

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PLOS ONE (2013)

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Review Oncology

Nitric oxide and cancer: a review

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WORLD JOURNAL OF SURGICAL ONCOLOGY (2013)

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Review Biotechnology & Applied Microbiology

Survivin - biology and potential as a therapeutic target in oncology

Chun Hei Antonio Cheung et al.

ONCOTARGETS AND THERAPY (2013)

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Article Cell Biology

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

Henning Walczak

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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Review Cell Biology

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

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CELL DEATH & DISEASE (2013)

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Editorial Material Plant Sciences

Structure diversity of nitric oxide synthases (NOS): the emergence of new forms in photosynthetic organisms

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FRONTIERS IN PLANT SCIENCE (2013)

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Article Cell Biology

Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells

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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

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Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance

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CANCER LETTERS (2012)

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Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer

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Survivin promotes glioma angiogenesis through vascular endothelial growth factor and basic fibroblast growth factor in vitro and in vivo

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NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils

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Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells

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CURRENT OPINION IN PHARMACOLOGY (2011)

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Survivin and escaping in therapy-induced cellular senescence

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Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity

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The survivin-31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival

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Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1

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Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

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Nitric Oxide and Cancer Therapy: The Emperor has NO Clothes

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Regulation of ERα-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: Implications for breast cancer cell survival

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The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

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BI-97C1, an Optically Pure Apogossypol Derivative as Pan-Active Inhibitor of Antiapoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

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A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

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MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer

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Runx2-Mediated bcl-2 Gene Expression Contributes to Nitric Oxide Protection Against Hydrogen Peroxide-induced Osteoblast Apoptosis

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Nitric oxide synthase gene therapy enhances the toxicity of cisplatin in cancer cells

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JOURNAL OF GENE MEDICINE (2009)

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Prognostic Role of Myeloid Cell Leukemia-1 Protein (Mcl-1) Expression in Human Gastric Cancer

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Nitric Oxide Induces Cell Death by Regulating Anti-Apoptotic BCL-2 Family Members

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MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

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S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

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Over-Expression of c-FLIP Confers the Resistance to TRAIL-Induced Apoptosis on Gallbladder Carcinoma

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Dimeric procyanidin B2 inhibits constitutively active NF-κB in Hodgkin's lymphoma cells independently of the presence of IκB mutations

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Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

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Increased inducible nitric oxide synthase in lung carcinoma of smokers

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NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas

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IGF-I protects human oral buccal mucosal epithelial cells from sodium nitroprusside-induced apoptosis via PI3-kinase

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Role of S-nitrosylation in apoptosis resistance and carcinogenesis

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NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2008)

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Regulation of apoptosis-related genes by nitric oxide in cancer

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NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2008)

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CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway

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MCL-1 inhibits BAX in the absence of MCL-1/BAX interaction

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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Review Pharmacology & Pharmacy

Review - Recent developments in nitric oxide donor drugs

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Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation

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Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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mir-29 regulates Mcl-1 protein expression and apoptosis

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ONCOGENE (2007)

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Statin-induced breast cancer cell death: Role of inducible nitric oxide and arginase-dependent pathways

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Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells

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Bcl-2 family proteins are essential for platelet survival

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Inflammation and IGF-I activate the Akt pathway in breast cancer

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Mutagenesis induced by the nitric oxide donor sodium nitroprusside in mouse cells

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Apoptosis: A review of programmed cell death

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Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

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CELL DEATH AND DIFFERENTIATION (2007)

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Redox signaling: Bioinorganic chemistry at its best

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Enhanced formation of nitric oxide in bladder carcinoma in situ and in BCG treated bladder cancer

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S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation -: A novel antiapoptotic mechanism that suppresses apoptosis

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Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak

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ENDOCRINOLOGY (2006)

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Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells

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CELL DEATH AND DIFFERENTIATION (2006)

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Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination

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Nitric oxide synthases are associated with bronchial dysplasia

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LUNG CANCER (2006)

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STAT3-mediated transcription of Bcl-2, Mcl-1 and c-lAP2 prevents apoptosis in polyamine-depleted cells

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Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-only, and BNip families of apoptotic regulators

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Overexpressed β-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells

HY Wang et al.

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NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells

A Spiegel et al.

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Nitric oxide induces oral squamous cell carcinoma cells apoptosis with p53 accumulation

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ORAL ONCOLOGY (2005)

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Differential requirements for survivin in hematopoietic cell development

S Gurbuxani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine

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NATURE CHEMICAL BIOLOGY (2005)

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Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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NATURE (2005)

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Expression of bcl-2 in classical Hodgkin's lymphoma: An independent predictor of poor outcome

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JOURNAL OF CLINICAL ONCOLOGY (2005)

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Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival

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Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion

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S-nitrosation regulates the activation of endogenous procaspase-9 in HT-29 human colon carcinoma cells

JE Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Inhibition of interleukin-12 p40 transcription and NF-κB activation by nitric oxide in murine macrophages and dendritic cells

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Apoptosis pathways in cancer and cancer therapy

KM Debatin

CANCER IMMUNOLOGY IMMUNOTHERAPY (2004)

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Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells

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Review Pharmacology & Pharmacy

Regulation of the expression of inducible nitric oxide synthase

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Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro

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A mutation found in the promoter region of the human Survivin gene is correlated to overexpression of survivin in cancer cells

Y Xu et al.

DNA AND CELL BIOLOGY (2004)

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An IAP-IAP complex inhibits apoptosis

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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-κB and inhibition of Bcl-xL expression

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ONCOGENE (2004)

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Review Oncology

Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice

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CANCER RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells

JI Chao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

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GENES & DEVELOPMENT (2003)

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Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia

FT Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

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Endogenous nitric oxide downregulates the Bcl-2 expression of eosinophils through mitogen-activated protein kinase in bronchial asthma

SH Maa et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2003)

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Review Physiology

Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide

BC Kone et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)

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Article Biochemistry & Molecular Biology

Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis

K Kawasaki et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

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Article Biochemistry & Molecular Biology

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

O Micheau et al.

CELL (2003)

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Article Biochemistry & Molecular Biology

HBXIP functions as a cofactor of survivin in apoptosis suppression

H Marusawa et al.

EMBO JOURNAL (2003)

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Article Pathology

Survivin expression in ovarian carcinoma: Correlation with apoptotic markers and prognosis

C Cohen et al.

MODERN PATHOLOGY (2003)

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Article Oncology

Bcl-2 is significantly overexpressed in localized radio-recurrent prostate carcinoma, compared with localized radio-naive prostate carcinoma

CJ Rosser et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2003)

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Review Cell Biology

The role of nitric oxide in cancer

WM Xu et al.

CELL RESEARCH (2002)

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Article Biochemistry & Molecular Biology

Phosphorylation and inactivation of myelbid cell leukemia 1 by JNK in response to oxidative stress

S Inoshita et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Oncology

Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy

S Loibl et al.

CANCER (2002)

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Article Medical Laboratory Technology

Oxidant-antioxidant status in patients with oral squamous cell carcinomas at different intraoral sites

R Subapriya et al.

CLINICAL BIOCHEMISTRY (2002)

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Review Oncology

The BCL2 family: Regulators of the cellular life-or-death switch

S Cory et al.

NATURE REVIEWS CANCER (2002)

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Article Dentistry, Oral Surgery & Medicine

Increased expression of inducible nitric oxide synthase for human oral submucous fibrosis, verrucous hyperplasia, and verrucous carcinoma

YK Chen et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2002)

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Review Cell Biology

IAP proteins: Blocking the road to death's door

GS Salvesen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

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Review Oncology

A matter of life and death

DR Green et al.

CANCER CELL (2002)

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Article Biochemistry & Molecular Biology

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

G van Loo et al.

CELL DEATH AND DIFFERENTIATION (2002)

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Review Cell Biology

Opinion - Does nitric oxide modulate mitochondrial energy generation and apoptosis?

S Moncada et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

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Article Biochemistry & Molecular Biology

Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures

S Canals et al.

JOURNAL OF NEUROCHEMISTRY (2001)

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Article Cell Biology

S-nitrosylation of mitochondrial caspases

JB Mannick et al.

JOURNAL OF CELL BIOLOGY (2001)

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Article Multidisciplinary Sciences

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

S Oyadomari et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Biochemistry & Molecular Biology

Bcl-xS can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-xS to the mitochondria and its BH3 and loop domains

L Lindenboim et al.

CELL DEATH AND DIFFERENTIATION (2001)

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Review Immunology

The regulatory role of nitric oxide in apoptosis

PKM Kim et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2001)

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Article Biochemistry & Molecular Biology

Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway

A Musial et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Structural basis for the inhibition of caspase-3 by XIAP

SJ Riedl et al.

CELL (2001)

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Article Multidisciplinary Sciences

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

SM Srinivasula et al.

NATURE (2001)

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Article Biochemistry & Molecular Biology

An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7

S Shin et al.

BIOCHEMISTRY (2001)

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Article Biochemistry & Molecular Biology

Mechanisms of p53-dependent apoptosis

M Schuler et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2001)

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Article Biochemistry & Molecular Biology

XIAP: Apoptotic brake and promising therapeutic target

M Holcik et al.

APOPTOSIS (2001)

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Article Genetics & Heredity

Human T-cell leukemia virus type I Tax protein induces the expression of anti-apoptotic gene Bcl-x(L) in human T-cells through nuclear factor-kappa B and c-AMP responsive element binding protein pathways

N Mori et al.

VIRUS GENES (2001)

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Article Multidisciplinary Sciences

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

DS O'Connor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Article Biochemistry & Molecular Biology

Nitric oxide down-regulates MKP-3 mRNA levels -: Involvement in endothelial cell protection from apoptosis

L Rössig et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Review Cell Biology

The morphology of apoptosis

G Häcker

CELL AND TISSUE RESEARCH (2000)

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Article Multidisciplinary Sciences

Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

E Oda et al.

SCIENCE (2000)

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Article Gastroenterology & Hepatology

Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma

AI Sarela et al.

GUT (2000)

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Article Dermatology

Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma

U Leiter et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2000)

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Article Biochemistry & Molecular Biology

Bcl-xL promotes metastasis of breast cancer cells by induction of cytokines resistance

Y Fernández et al.

CELL DEATH AND DIFFERENTIATION (2000)

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Article Neurosciences

Nitric oxide induces differentiation in the NB69 human catecholamine-rich cell line

E Rodriguez-Martin et al.

NEUROPHARMACOLOGY (2000)

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Article Multidisciplinary Sciences

Prokaryotic regulation of epithelial responses by inhibition of I kappa B-alpha ubiquitination

AS Neish et al.

SCIENCE (2000)

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