4.7 Article

PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Novel Phage Lysin Abp013 against Acinetobacter baumannii

Joash Jun Keat Chu et al.

Summary: As antimicrobial resistance becomes a growing health threat, the need for novel therapeutic agents is urgent. This study identifies a lysin called Abp013 that exhibits significant lytic activity against drug-resistant strains of Acinetobacter baumannii. Abp013 is able to tolerate the presence of human serum and effectively kill bacterial cells within biofilms. These findings suggest that Abp013 holds promising potential as a novel therapeutic agent.

ANTIBIOTICS-BASEL (2022)

Article Microbiology

Isolation of Klebsiella pneumoniae Phage vB_KpnS_MK54 and Pathological Assessment of Endolysin in the Treatment of Pneumonia Mice Model

Biao Lu et al.

Summary: A lytic phage, vB_KpnS_MK54, was isolated from the drinking water of a forest musk deer farm in Sichuan Province. The phage showed high specificity for lytic host bacteria and moderate adaptability to different environments. Whole-genome sequencing analysis revealed a genome size of 46,218 bp with 80 coding DNA sequences, including the phage endolysin LysG24. A new peptide-modified endolysin, LysCA, was constructed and exhibited stronger antibacterial activity and environmental adaptability than LysG24. In in vivo tests using a mouse model of pneumonia, both LysG24 and LysCA showed therapeutic effects by reducing the pulmonary inflammatory response, with LysCA displaying a more significant effect.

FRONTIERS IN MICROBIOLOGY (2022)

Review Microbiology

Direct Lytic Agents: Novel, Rapidly Acting Potential Antimicrobial Treatment Modalities for Systemic Use in the Era of Rising Antibiotic Resistance

Raymond Schuch et al.

Summary: Direct lytic agents (DLAs) are novel antimicrobial compounds that rapidly destabilize cell walls and kill bacteria. They can complement and synergize with traditional antibiotics without causing resistance to DLAs. DLAs have potent bactericidal activity against multidrug-resistant Gram-negative pathogens, and their activity is maintained in biological matrices. This makes them promising candidates for the treatment of life-threatening invasive infections.

FRONTIERS IN MICROBIOLOGY (2022)

Article Infectious Diseases

Treatment Heterogeneity in Pseudomonas aeruginosa Pneumonia

Aisling R. Caffrey et al.

Summary: This study identified substantial treatment heterogeneity among patients with P. aeruginosa pneumonia, with a majority of patients having unique patterns of antibiotic drug and duration.

ANTIBIOTICS-BASEL (2022)

Article Infectious Diseases

Current and future perspectives in the treatment of multidrug-resistant Gram-negative infections

Matteo Bassetti et al.

Summary: Microbial resistance is a serious threat to human health worldwide, especially with Gram-negative bacteria spreading resistance through mechanisms like AmpC enzymes, extended-spectrum beta-lactamases, and carbapenemases. Current treatments for multidrug-resistant Gram-negative bacteria involve a combination of older drugs and newer agents, with varying degrees of success. New treatment targets are also currently under investigation.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Review Infectious Diseases

State-of-the-art review of secondary pulmonary infections in patients with COVID-19 pneumonia

Woon H. Chong et al.

Summary: The incidence of secondary pulmonary infections in hospitalized COVID-19 patients is low, with bacterial infections at 16% (4.8-42.8%) and fungal infections at 6.3% (0.9-33.3%). These infections are predominantly seen in critically ill patients, with common bacterial microorganisms including Pseudomonas aeruginosa and Staphylococcus aureus, while Aspergillus fumigatus is the most common microorganism causing fungal infections. The time to diagnose these infections is around 10 days from initial hospitalization.

INFECTION (2021)

Article Food Science & Technology

Decontamination of Escherichia coli O157:H7 on fresh Romaine lettuce using a novel bacteriophage lysin

Siyue Xu et al.

Summary: Phages are showing potential as antimicrobial agents to reduce the risk of infections from contaminated produce. A novel lysin named PlyEc2 demonstrated high bactericidal activity against gram-negative pathogens, particularly STEC, in fresh lettuce without affecting their visual and tactile quality.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2021)

Article Immunology

A Novel Acinetobacter baumannii Bacteriophage Endolysin LysAB54 With High Antibacterial Activity Against Multiple Gram-Negative Microbes

Fazal Mehmood Khan et al.

Summary: The study isolated and characterized a bacteriophage p54 and its endolysin LysAB54 which showed significant bactericidal activity against multidrug-resistant Gram-negative superbugs including A. baumannii. This suggests that LysAB54 could potentially serve as a therapeutic agent for treating these bacteria.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Microbiology

Mobile Carbapenemase Genes in Pseudomonas aeruginosa

Eun-Jeong Yoon et al.

Summary: This article highlights the challenge of carbapenem-resistant Pseudomonas aeruginosa in clinical settings, focusing on the global mechanisms of carbapenem resistance and the horizontal dissemination of drug resistance determinants through mobile genetic elements. The review also examines the modular mobile elements, including carbapenemase-encoding genes, for their structures and implications in antimicrobial therapy.

FRONTIERS IN MICROBIOLOGY (2021)

Article Microbiology

Discovering the Potentials of Four Phage Endolysins to Combat Gram-Negative Infections

Daria V. Vasina et al.

Summary: Endolysin-based therapeutics show promise as antibacterial agents, especially against Gram-negative pathogens. This study comprehensively investigated four Gram-negative bacteria-targeting endolysins for their antimicrobial efficacy, activity, and biological safety, demonstrating broad spectrum effectiveness with minimal safety concerns.

FRONTIERS IN MICROBIOLOGY (2021)

Review Infectious Diseases

Endolysins as emerging alternative therapeutic agents to counter drug-resistant infections

Vijay Singh Gondil et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Microbiology

Pseudomonas phragmitis sp. nov., isolated from petroleum polluted river sediment

Jing Li et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2020)

Review Microbiology

Klebsiella pneumoniae: an increasing threat to public health

Clement Yaw Effah et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2020)

Article Infectious Diseases

Antimicrobial activity of LysSS, a novel phage endolysin, against Acinetobacter baumannii and Pseudomonas aeruginosa

Shukho Kim et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

Article Medicine, Research & Experimental

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

Vance G. Fowler et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Infectious Diseases

Gram-Negative Bacterial Lysins

Chandrabali Ghose et al.

ANTIBIOTICS-BASEL (2020)

Review Biotechnology & Applied Microbiology

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Zheng Pang et al.

BIOTECHNOLOGY ADVANCES (2019)

Review Infectious Diseases

Present and Future of Carbapenem-resistant Enterobacteriaceae (CRE) Infections

Beatriz Suay-Garcia et al.

ANTIBIOTICS-BASEL (2019)

Article Biotechnology & Applied Microbiology

Klebsiella phages representing a novel clade of viruses with an unknown DNA modification and biotechnologically interesting enzymes

Barbara Maciejewska et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)

Review Respiratory System

The respiratory threat posed by multidrug resistant Gram-negative bacteria

Ana Rodrigo-Troyano et al.

RESPIROLOGY (2017)

Review Microbiology

Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae

Liangfei Xu et al.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2017)

Article Multidisciplinary Sciences

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

Waqes Nasir Chaudhry et al.

PLOS ONE (2017)

Article Critical Care Medicine

Infection in burn patients in a referral center in Colombia

Carlos Enrique Ramirez-Blanco et al.

Review Biochemistry & Molecular Biology

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

Craig Winstanley et al.

TRENDS IN MICROBIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Bacteriophage phi11 lysin: Physicochemical characterization and comparison with phage phi80α lysin

Lyubov Y. Filatova et al.

ENZYME AND MICROBIAL TECHNOLOGY (2015)

Review Infectious Diseases

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology

Anais Potron et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2015)

Article Biochemistry & Molecular Biology

Deciphering key features in protein structures with the new ENDscript server

Xavier Robert et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Characterization of five novel endolysins from Gram-negative infecting bacteriophages

Maarten Walmagh et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2013)

Article Infectious Diseases

Impact of multidrug resistance on Pseudomonas aeruginosa ventilator-associated pneumonia outcome: predictors of early and crude mortality

C. Pena et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2013)

Article Virology

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins

Hugo Oliveira et al.

JOURNAL OF VIROLOGY (2013)

Letter Infectious Diseases

Klebsiella pneumoniae liver abscesses

Theresa Seetoh et al.

LANCET INFECTIOUS DISEASES (2013)

Article Biochemistry & Molecular Biology

Using a bacteriocin structure to engineer a phage lysin that targets Yersinia pestis

Petra Lukacik et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2012)

Review Microbiology

Bacteriophage endolysins as novel antimicrobials

Mathias Schmelcher et al.

FUTURE MICROBIOLOGY (2012)

Article Multidisciplinary Sciences

Structural engineering of a phage lysin that targets Gram-negative pathogens

Petra Lukacik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biotechnology & Applied Microbiology

Antibacterial activity of Acinetobacter baumannii phage ΦAB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria

Meng-Jiun Lai et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

Article Biotechnology & Applied Microbiology

Use of bacteriophage endolysin EL188 and outer membrane permeabilizers against Pseudomonas aeruginosa

Y. Briers et al.

JOURNAL OF APPLIED MICROBIOLOGY (2011)

Article Biotechnology & Applied Microbiology

Characterization of the staphylococcal bacteriophage lysin CHAPK

M. Fenton et al.

JOURNAL OF APPLIED MICROBIOLOGY (2011)

Review Microbiology

Tackling antibiotic resistance

Karen Bush et al.

NATURE REVIEWS MICROBIOLOGY (2011)

Review Microbiology

Pseudomonas genomes: diverse and adaptable

Mark W. Silby et al.

FEMS MICROBIOLOGY REVIEWS (2011)

Review Respiratory System

Pseudomonas aeruginosa: Host defence in lung diseases

Bryan J. Williams et al.

RESPIROLOGY (2010)

Article Biotechnology & Applied Microbiology

Bacillus amyloliquefaciens phage endolysin can enhance permeability of Pseudomonas aeruginosa outer membrane and induce cell lysis

Y Orito et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2004)

Article Multidisciplinary Sciences

A bacteriolytic agent that detects and kills Bacillus anthracis

R Schuch et al.

NATURE (2002)