XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus

Article Immunology

Risk Factors for Recurrent Staphylococcus aureus Bacteremia

Seong-Ho Choi et al.

Summary: This study identified several risk factors for R-SAB, with the highest risk observed among black hemodialysis patients. Higher levels of RANTES in R-SAB compared to matched controls suggest a need for further investigation.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Chemistry, Medicinal

Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors

Thomas Lanyon-Hogg

Summary: The review explores the role of the bacterial SOS pathway in combating drug-resistant pathogens, potential targets for inhibition such as AddAB, RecBCD, RecA, and LexA, and efforts to develop selective small-molecule inhibitors. These inhibitors may serve as valuable tools for combating drug resistance and developing novel antibacterial therapeutics.

FUTURE MEDICINAL CHEMISTRY (2021)

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Review Microbiology

Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects

Hao Li et al.

Summary: Reactive oxygen species (ROS) play key roles in antibiotic-mediated killing and host-mediated killing, but their involvement presents challenges and complexities. Certain bacterial pathogens thriving under ROS conditions suggest the need to focus on pathogen evolution to adapt to ROS.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Microbiology

SOS-Independent Pyocin Production in P. aeruginosa Is Induced by XerC Recombinase Deficiency

Nina S. Baggett et al.

Summary: Pyocins are used by Pseudomonas aeruginosa to compete with other strains, typically induced by DNA damage and the SOS response. Our discovery of a RecA-independent pathway for strong pyocin induction in XerC-deficient cells highlights a potential target for future therapies against P. aeruginosa infections.

MBIO (2021)

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Article Microbiology

RexAB Promotes the Survival of Staphylococcus aureus Exposed to Multiple Classes of Antibiotics

Rebecca S. Clarke et al.

Summary: Antibiotics inhibit bacterial growth and lead to cell death, while certain antibiotics can also induce the production of reactive oxygen species that damage bacterial DNA and promote drug resistance. Different classes of antibiotics were found to dose-dependently induce the SOS response in Staphylococcus aureus, indicating DNA damage, with the RexAB helicase/nuclease complex playing a key role in this process. This study confirms that several classes of antibiotics cause DNA damage in S. aureus and highlights the importance of RexAB in triggering the mutagenic SOS response and promoting bacterial survival.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Review Microbiology

DNA Repair in Staphylococcus aureus

Kam Pou Ha et al.

Summary: Staphylococcus aureus demonstrates remarkable adaptability and resistance in infections, with its DNA repair process playing a crucial role in pathogen survival within host tissues. Studies suggest that targeting staphylococcal DNA repair could be a potential novel therapeutic strategy.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2021)

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Article Infectious Diseases

Functional Analysis of theAcinetobacter baumanniiXerC and XerD Site-Specific Recombinases: Potential Role in Dissemination of Resistance Genes

David L. Lin et al.

ANTIBIOTICS-BASEL (2020)

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Article Microbiology

Staphylococcal DNA Repair Is Required for Infection

Kam Pou Ha et al.

MBIO (2020)

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Review Microbiology

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

Nicholas A. Turner et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Article Multidisciplinary Sciences

Cigarette smoke exposure redirects Staphylococcus aureus to a virulence profile associated with persistent infection

Alicia Lacoma et al.

SCIENTIFIC REPORTS (2019)

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Article Microbiology

RexAB Is Essential for the Mutagenic Repair of Staphylococcus aureus DNA Damage Caused by Co-trimoxazole

Rebecca S. Clarke et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

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Article Microbiology

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus

Kathryn A. Coe et al.

PLOS PATHOGENS (2019)

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Review Biochemistry & Molecular Biology

Transfer of Antibiotic Resistance in Staphylococcus aureus

Jakob Haaber et al.

TRENDS IN MICROBIOLOGY (2017)

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Review Immunology

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

Giang T. Nguyen et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

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Article Microbiology

Xer Site Specific Recombination: Double and Single Recombinase Systems

Fabio Castillo et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Immunology

The Electron Transport Chain Sensitizes Staphylococcus aureus and Enterococcus faecalis to the Oxidative Burst

Kimberley L. Painter et al.

INFECTION AND IMMUNITY (2017)

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Article Immunology

XerC Contributes to Diverse Forms of Staphylococcus aureus Infection via agr-Dependent and agr-Independent Pathways

Danielle N. Atwood et al.

INFECTION AND IMMUNITY (2016)

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Article Biology

Structural basis for the inhibition of RecBCD by Gem and its synergistic antibacterial effect with quinolones

Martin Wilkinson et al.

ELIFE (2016)

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Article Microbiology

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus

Martin Vestergaard et al.

FRONTIERS IN MICROBIOLOGY (2016)

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Article Biotechnology & Applied Microbiology

A new platform for ultra-high density Staphylococcus aureus transposon libraries

Marina Santiago et al.

BMC GENOMICS (2015)

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Article Multidisciplinary Sciences

Antibiotics induce redox-related physiological alterations as part of their lethality

Daniel J. Dwyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Microbiology

Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies

Michael D. Valentino et al.

MBIO (2014)

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Article Infectious Diseases

Opposing effects of aminocoumarins and fluoroquinolones on the SOS response and adaptability in Staphylococcus aureus

Wiebke Schroeder et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)

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Article Biotechnology & Applied Microbiology

Exonuclease VII is involved in reckless DNA degradation in UV-irradiated Escherichia coli

Jelena Repar et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2013)

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Article Microbiology

A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes

Paul D. Fey et al.

MBIO (2013)

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Review Cell Biology

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

Julian E. Sale et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

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Review Immunology

Neutrophils in innate host defense against Staphylococcus aureus infections

Kevin M. Rigby et al.

SEMINARS IN IMMUNOPATHOLOGY (2012)

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Article Genetics & Heredity

SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli

Tobias Doerr et al.

PLOS GENETICS (2009)

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Article Biochemical Research Methods

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

Irith Wiegand et al.

NATURE PROTOCOLS (2008)

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Article Biochemistry & Molecular Biology

A common mechanism of cellular death induced by bactericidal antibiotics

Michael A. Kohanski et al.

CELL (2007)

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Article Microbiology

Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus

Angelika Grundling et al.

JOURNAL OF BACTERIOLOGY (2007)

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Article Microbiology

Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin

Ryan T. Cirz et al.

JOURNAL OF BACTERIOLOGY (2007)

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Article Microbiology

β-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus

E Maiques et al.

JOURNAL OF BACTERIOLOGY (2006)

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Article Microbiology

Differences in resolution of mwr-containing plasmid dimers mediated by the Klebsiella pneumoniae and Escherichia coli XerC recombinases:: Potential implications in dissemination of antibiotic resistance genes

DY Bui et al.

JOURNAL OF BACTERIOLOGY (2006)

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Article Biochemistry & Molecular Biology

Antibiotic-induced SOS response promotes horizontal dissemination of pathogenicity island-encoded virulence factors in staphylococci

C Ubeda et al.

MOLECULAR MICROBIOLOGY (2005)

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Article Medicine, General & Internal

Staphylococcus aureus bacteremia -: Recurrence and the impact of antibiotic treatment in a prospective multicenter study

FY Chang et al.

MEDICINE (2003)

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Article Biochemistry & Molecular Biology

Cell division, guillotining of dimer chromosomes and SOS induction in resolution mutants (dif, xerC and xerD) of Escherichia coli

EC Hendricks et al.

MOLECULAR MICROBIOLOGY (2000)

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XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus

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