4.3 Article

ATG9B Is a Poor Prognostic Marker Associated With Immune Evasion in Colon Adenocarcinoma

期刊

ANTICANCER RESEARCH
卷 43, 期 5, 页码 1943-1957

出版社

INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.16354

关键词

Key Words; Autophagy; colonic neoplasms; chromosomal instability; tumor microenvironment; immune evasion

类别

向作者/读者索取更多资源

This study found that ATG9B has the highest expression levels among ATGs in colon adenocarcinoma (COAD), and it is associated with advanced stage and poor prognosis. Additionally, ATG9B expression is positively correlated with consensus molecular subtype 4 and chromosomal instability, but negatively correlated with tumor mutation burden. High ATG9B expression levels are associated with low immune cell infiltration and decreased expression of natural killer cell activation genes.
Background/Aim: Autophagy-related genes (ATGs) are involved in autophagy activation, which has a pleiotropic role in cancer development. However, the potential value of ATG expression levels in colon adenocarcinoma (COAD) is unclear. This study aimed to examine the modulation of ATG expression levels and their association with clinical and molecular aspects of COAD. Materials and Methods: We used the clinical and molecular phenotypes and RNA sequencing datasets of the cancer genome atlas (TCGA)-COAD project using TCGAbiolinks and cBioPortal. Comparisons of ATG expression levels between tumor and normal tissues were performed using DESeq2 within R. Gene expression and immune cell infiltration levels were analyzed by TIMER. Results: ATG9B had the highest expression levels among ATGs in COAD tissues compared to normal tissues and was related to advanced stage and poor prognosis in COAD. In addition, ATG9B expression was positively associated with the consensus molecular subtype 4 and chromosomal instability but negatively correlated with tumor mutation burden. Furthermore, high ATG9B expression levels were associated with low immune cell infiltration and decreased expression of natural killer cell activation genes. Conclusion: ATG9B is a poor prognostic biomarker driving immune evasion of COAD through negative correlation with immune cell infiltration.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据