Positron Emission Tomography with [18F]-DPA-714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression

Review Clinical Neurology

In vivo imaging of chronic active lesions in multiple sclerosis

Alberto Calvi et al.

Summary: Chronic active lesions in multiple sclerosis (MS) are characterized by ongoing inflammation and tissue injury, and identifying imaging markers for these lesions is an important research goal.

MULTIPLE SCLEROSIS JOURNAL (2022)

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Article Clinical Neurology

A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis

Reza Rahmanzadeh et al.

Summary: This study demonstrates the possibility of distinguishing chronic lesions in multiple sclerosis in a clinical setting and provides support for the development and assessment of remyelinating treatments using new biomarkers.

ANNALS OF NEUROLOGY (2022)

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Review Neurosciences

Microglia in multiple sclerosis: Protectors turn destroyers

V. Wee Yong

Summary: This article discusses the role of microglia in multiple sclerosis and analyzes the changes of microglia during the course of the disease and the factors that lead to their loss of protective states. Meanwhile, medications that affect microglia are evaluated, and new approaches to counter microglia-driven neurodegeneration are explored.

NEURON (2022)

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Article Clinical Neurology

Imaging Characteristics of Choroid Plexuses in Presymptomatic Multiple Sclerosis A Retrospective Study

Vito A. G. Ricigliano et al.

Summary: By using MRI and PET imaging, this study found changes in the choroid plexus (CP) in patients at the earliest stage of multiple sclerosis (MS), including larger CP volume and higher inflammation response. These findings suggest that CP imaging may serve as an early biomarker for MS and support the involvement of blood-CSF barrier dysfunction in disease development.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2022)

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Article Clinical Neurology

Phenotyping of multiple sclerosis lesions according to innate immune cell activation using 18 kDa translocator protein-PET

Marjo Nylund et al.

Summary: The study used 18 kDa translocator protein-PET imaging to phenotype chronic lesions in multiple sclerosis, finding that secondary progressive patients had a higher proportion of rim-active lesions compared to relapsing-remitting patients, and these lesions were correlated with disability.

BRAIN COMMUNICATIONS (2022)

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Review Allergy

Specialized Pro-Resolving Lipid Mediators: Emerging Therapeutic Candidates for Multiple Sclerosis

Insha Zahoor et al.

Summary: Multiple sclerosis (MS) is a neuroinflammatory disease where the role of specialized pro-resolving lipid mediators (SPMs) is contentious due to variable outcomes in biological matrices across studies, possibly attributed to differences in population characteristics.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

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Article Clinical Neurology

Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis

Emilie Poirion et al.

Summary: The study revealed that innate immune cell activation predominates in periventricular regions in MS patients and is associated with microstructural damage and disability worsening. This could be due to the diffusion of proinflammatory CSF-derived factors into surrounding tissues.

NEUROLOGY (2021)

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Article Neurosciences

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain

Erik Nutma et al.

Summary: The expression of TSPO in the human central nervous system may reflect cell density rather than activation status of microglia/macrophages. This has implications for interpreting TSPO PET signals in MS and other CNS diseases, highlighting the limitations of extrapolating TSPO biology from rodents to humans.

GLIA (2021)

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Article Multidisciplinary Sciences

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

Martina Absinta et al.

Summary: Through MRI-guided single-nucleus RNA sequencing, a diversity of glial and immune cells at the edge of demyelinated white matter lesions in multiple sclerosis (MS) have been identified, along with the definition of inflamed glial cell phenotypes in MS. The overlap of the transcriptional profile of microglia inflamed in MS with that in other neurodegenerative diseases suggests common mechanisms between primary and secondary neurodegeneration that could benefit from similar therapeutic approaches. The critical role of complement component 1q (C1q) in the activation of microglia inflamed in MS has been identified and potential therapeutic avenues, such as C1q inhibition, have been suggested for addressing chronic white matter inflammation.

NATURE (2021)

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Review Clinical Neurology

Positron emission tomography in multiple sclerosis - straight to the target

Benedetta Bodini et al.

Summary: With significant progress in treating relapsing-remitting MS, the main challenge now is developing treatments to prevent or delay progressive forms of the disease. A deep understanding of the mechanisms behind neuro-axonal degeneration is crucial for developing therapies for progressive MS. PET imaging plays a key role in providing insights into the mechanisms of irreversible neuro-axonal damage in MS.

NATURE REVIEWS NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans

Vinzenz Fleischer et al.

Summary: The enlargement of ChP is closely associated with acute disease activity in both studied mouse models and humans, suggesting it as a potential interspecies marker for neuroinflammation that relates to functional impairment. Pharmacological modulation of the blood-CSF barrier with natalizumab prevents ChP volume increase and shows a close dependency of ChP integrity on molecular signatures of neuroinflammation. These findings suggest ChP characteristics as robust and translatable hallmarks of acute and ongoing neuroinflammatory activity in mice and humans.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Individual Mapping of Innate Immune Cell Activation Is a Candidate Marker of Patient-Specific Trajectories of Worsening Disability in Multiple Sclerosis

Benedetta Bodini et al.

JOURNAL OF NUCLEAR MEDICINE (2020)

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Article Clinical Neurology

Lesion stage-dependent causes for impaired remyelination in MS

Katharina Hess et al.

ACTA NEUROPATHOLOGICA (2020)

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Article Clinical Neurology

Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials

Ludwig Kappos et al.

JAMA NEUROLOGY (2020)

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Article Clinical Neurology

Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis

Laura Starost et al.

ACTA NEUROPATHOLOGICA (2020)

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Article Clinical Neurology

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

Marcus Sucksdorff et al.

BRAIN (2020)

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Article Clinical Neurology

Evaluation of the 'ring sign' and the 'core sign' as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis

Nelly Blindenbacher et al.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2020)

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Article Clinical Neurology

What Are the Minimal Detectable Changes in SDMT and Verbal Fluency Tests for Assessing Changes in Cognitive Performance in Persons with Multiple Sclerosis and Non-Multiple Sclerosis Controls?

Eloi Magnin et al.

EUROPEAN NEUROLOGY (2020)

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Article Multidisciplinary Sciences

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Sarah Jakel et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Neuronal vulnerability and multilineage diversity in multiple sclerosis

Lucas Schirmer et al.

NATURE (2019)

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Review Clinical Neurology

The pro-remyelination properties of microglia in the central nervous system

Amy F. Lloyd et al.

NATURE REVIEWS NEUROLOGY (2019)

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Article Clinical Neurology

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

Colm Elliott et al.

BRAIN (2019)

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Article Clinical Neurology

Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis

Anand J. C. Eijlers et al.

NEUROLOGY (2019)

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Article Clinical Neurology

Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Martina Absinta et al.

JAMA NEUROLOGY (2019)

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Article Clinical Neurology

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

Erik Nutma et al.

BRAIN (2019)

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Article Clinical Neurology

Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions

Ulrike W. Kaunzner et al.

BRAIN (2019)

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Article Clinical Neurology

Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions

Colm Elliott et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

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Article Endocrinology & Metabolism

Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies

Daniel Garcia-Lorenzo et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

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Article Clinical Neurology

Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis

Sabina Luchetti et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Clinical Neurology

An Automated Statistical Technique for Counting Distinct Multiple Sclerosis Lesions

J. D. Dworkin et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2018)

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Review Clinical Neurology

Cognition in multiple sclerosis: State of the field and priorities for the future

James F. Sumowski et al.

NEUROLOGY (2018)

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Article Clinical Neurology

Microglial activation, white matter tract damage, and disability in MS

Eero Rissanen et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2018)

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Article Clinical Neurology

Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging

Assunta Dal-Bianco et al.

ACTA NEUROPATHOLOGICA (2017)

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Article Clinical Neurology

An updated histological classification system for multiple sclerosis lesions

Tanja Kuhlmann et al.

ACTA NEUROPATHOLOGICA (2017)

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Article Clinical Neurology

The EDSS-Plus, an improved endpoint for disability progression in secondary progressive multiple sclerosis

Diego Cadavid et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

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Article Clinical Neurology

The EDSS-Plus, an improved endpoint for disability progression in secondary progressive multiple sclerosis

Diego Cadavid et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

11C-PBR28 and 18F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis

Gourab Datta et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

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Review Clinical Neurology

Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis

Ralph H. B. Benedict et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

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Review Clinical Neurology

Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis

Ralph H. B. Benedict et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

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Article Clinical Neurology

Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis

Tobias Zrzavy et al.

BRAIN (2017)

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Article Clinical Neurology

Adaptive human immunity drives remyelination in a mouse model of demyelination

Mohamed El Behi et al.

BRAIN (2017)

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Article Clinical Neurology

Neuroinflammatory component of gray matter pathology in multiple sclerosis

Elena Herranz et al.

ANNALS OF NEUROLOGY (2016)

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Article Medicine, Research & Experimental

Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions

Martina Absinta et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Clinical Neurology

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

Josa M. Frischer et al.

ANNALS OF NEUROLOGY (2015)

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Review Biochemistry & Molecular Biology

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

Michal Schwartz et al.

EMBO JOURNAL (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18F-PBR111 PET

Alessandro Colasanti et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

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Article Neuroimaging

Jacobian integration method increases the statistical power to measure gray matter atrophy in multiple sclerosis

Kunio Nakamura et al.

NEUROIMAGE-CLINICAL (2014)

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Article Endocrinology & Metabolism

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

David R. Owen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

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Article Clinical Neurology

Quantitative In Vivo Magnetic Resonance Imaging of Multiple Sclerosis at 7 Tesla with Sensitivity to Iron

Kathryn E. Hammond et al.

ANNALS OF NEUROLOGY (2008)

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Article Clinical Neurology

Diagnostic criteria for multiple sclerosis: 2005 Revisions to the McDonald Criteria

CH Polman et al.

ANNALS OF NEUROLOGY (2005)

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Article Clinical Neurology

Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability

N De Stefano et al.

ARCHIVES OF NEUROLOGY (2001)

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Positron Emission Tomography with [18F]-DPA-714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression

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