Evaluation of ethnic differences in cardiometabolic risk in children

Purpose: In adults, cardiometabolic conditions manifest differently by ethnicity with South Asians particularly predisposed. Whether these differences arise in childhood remains narrowly explored. To address this evidence gap, we examined whether children of different ethnicities display differences in cardiometabolic risk (CMR). Methods: A cross-sectional analysis was conducted among 5557 children (3-11 years). Multivariable linear regression models adjusted for age, sex, z-body mass index, and demographic factors were used to estimate differences in CMR outcomes between children with parents that self-reported European ancestry (reference group) and one of 13 other ethnicities (African, Arab, East Asian, Latin American, South Asian, Southeast Asian, Mixed Ethnicities, and Other). The primary outcome was a CMR score, calculated as the sum of age- and sex-standardized waist circumference, systolic blood pressure (SBP), glucose, log-triglycerides, and inverse high-density lipoprotein cholesterol (HDL-C), divided by root 5. Results: Lower mean CMR scores were observed among children with African (beta = -0.62, 95% CI: -0.92; -0.32) and East Asian (beta = -0.41, 95% CI: -0.68, -0.15) ancestry compared to children with European ancestry. Children with South Asian ancestry had higher SBP (beta = 2.25, 95% CI: 1.27, 3.22) and non-HDL-C (beta = 0.17, 95% CI: 0.07, 0.26) than children with European ancestry. Conclusions: Ethnic differences in CMR were observed in early and middle childhood. (c) 2023 Elsevier Inc. All rights reserved.

Automated summary

Ethnic differences in cardiometabolic risk were observed among children, with lower CMR scores in children with African and East Asian ancestry, and higher SBP and non-HDL-C in children with South Asian ancestry.