期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 48, 页码 15543-15546出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b10433
关键词
-
资金
- Austrian Science Fund (FWF) [P28866-N34]
This study represents the first example an environmentally benign, sustainable, and practical synthesis of substituted quinolines and pyrimidines using combinations of 2-aminobenzyl alcohols and alcohols as well as benzamidine and two different alcohols, respectively. These reactions proceed with high atom efficiency via a sequence of dehydrogenation and condensation steps that give rise to selective C-C and C-N bond formations, thereby releasing 2 equiv of hydrogen and water. A hydride Mn(I) PNP pincer complex recently developed in our laboratory catalyzes this process in a very efficient way. A total of 15 different quinolines and 14 different pyrimidines were synthesized in isolated yields of up to 91 and 90%, respectively.
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