期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 15, 页码 5000-5003出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b02391
关键词
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资金
- NIH [GM043214]
- NSF predoctoral fellowship
- NIH postdoctoral fellowship
We describe a direct, catalytic approach to the 1,2-difluorination of alkenes. The method utilizes a nucleophilic fluoride source and an oxidant in conjunction with an aryl iodide catalyst and is applicable to alkenes With all types of substitution patterns.. In general, the vicinal difluoride products are produced with high diastereoselectivities. The observed sense of stereo induction implicates anchimeric assistance pathways in reactions of alkenes bearing neighboring Lewis basic functionality.
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