期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202303288
关键词
Enzyme-Mimicking Catalysis; Metal-Organic Cage; Noncovalent Interactions; Supermolecular Reactor; Visible Light Photocatalysis
A visible light photosensitizing metal-organic cage is used as an artificial supramolecular reactor to control the reaction of aryl radicals with terminal olefins, resulting in the selective transformation of geometrically defined E/Z-alkenes. The hydrophobic cage efficiently includes aromatic substrates, promoting Meerwein arylation and protecting E-isomeric products, while benzonitrile induces efficient E -> Z isomerization. In addition to pi-pi stacking, hydrogen bonding and halogen bonding interactions play a role in controlling the arylation of aliphatic terminal olefins. This switchable cage-confined arylation catalysis has been demonstrated in the syntheses of Tapinarof and a marine natural product, achieving controllable E/Z selectivity.
A visible light photosensitizing metal-organic cage is applied as an artificial supramolecular reactor to control the reaction of aryl radicals with terminal olefins under green light/solvent conditions, which facilitates selective transformation in the confined enzyme-mimicking environment to give a series of geometrically defined E/Z-alkenes. The hydrophobic cage displays good host-guest inclusion with aromatic substrates, promoting Meerwein arylation and protecting E-isomeric products during reaction; while a small amount of benzonitrile can turn on efficient E -> Z isomerization. Besides pi-pi stacking, the hydrogen bonding and halogen bonding interactions also act as control forces for the arylation of aliphatic terminal olefins known as poor acceptors in classic Meerwein arylation. The application of this switchable cage-confined arylation catalysis has been demonstrated by the syntheses of Tapinarof and a marine natural product from the same substrate via controllable E/Z selectivity.
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