Additive-Free Transfer Hydrogenative Direct Asymmetric Reductive Amination Using a Chiral Pyridine-Derived Half-Sandwich Catalyst

Article Chemistry, Multidisciplinary

Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines

Fei-Fei Chen et al.

Summary: The direct synthesis of a wide range of sterically demanding secondary amines using imine reductases has been achieved, enabling the production of important pharmaceutical ingredients and intermediates.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

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Article Chemistry, Multidisciplinary

Pd-Catalyzed Amination of Base-Sensitive Five-Membered Heteroaryl Halides with Aliphatic Amines

Elaine C. Reichert et al.

Summary: We report a versatile method for the Pd-catalyzed C-N cross-coupling of heteroaryl halides with primary and secondary amines, achieving good-to-excellent yields. The use of a specific base and a supported Pd catalyst enables the coupling of challenging heteroarenes and sterically demanding amines. This method has broad applicability and allows the synthesis of densely functionalized medicinal chemistry building blocks.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

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Article Chemistry, Multidisciplinary

A Chemoenzymatic Cascade Combining a Hydration Catalyst with an Amine Dehydrogenase: Synthesis of Chiral Amines

Fengwei Chang et al.

Summary: The combination of biocatalysis and transition-metal catalysis can bridge synthetic gaps in chemical or biological processes, but the deactivation between enzymatic and chemical species poses a significant challenge. Researchers developed an encapsulated Au/carbene and free amine dehydrogenase co-catalyst system, enabling efficient hydration/amination enantioselective cascade reaction.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Design and Synthesis of Tunable Chiral 2,2′-Bipyridine Ligands: Application to the Enantioselective Nickel-Catalyzed Reductive Arylation of Aldehydes

Shuai Zhang et al.

Summary: A new class of chiral bipyridine ligands, SBpy, featuring minimized steric hindrance and structural tunability, was designed and developed for the highly enantioselective Ni-catalyzed addition reaction. Compared to known methods, this reaction is more cost-effective and tolerant towards functional groups. The proposed reaction mechanism and stereocontrol model were based on experimental and computational results.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Independent gradient model based on Hirshfeld partition: A new method for visual study of interactions in chemical systems

Tian Lu et al.

Summary: The powerful independent gradient model (IGM) method has limitations in graphically studying weak interactions. In this article, an improved version of IGM, called IGM based on Hirshfeld partition (IGMH), is proposed to overcome the shortcomings. The rigorous physical background of IGMH is demonstrated through various application examples, showcasing its important value in intuitively understanding interactions in chemical systems.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2022)

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Article Chemistry, Organic

Construction of axially chiral styrene-type allylamines via chiral phosphoric acid-catalyzed asymmetric reductive amination

You-Dong Shao et al.

Summary: The first enantioselective synthesis of axially chiral styrene-type allylamines was achieved through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols. This protocol features a broad substrate scope, good enantioselectivities (up to 90% ee) and mild reaction conditions, providing a new entry to the challenging atropisomeric acyclic styrene scaffolds.

ORGANIC CHEMISTRY FRONTIERS (2022)

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Article Chemistry, Multidisciplinary

Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase

Weixi Kong et al.

Summary: We report the engineering of an amine dehydrogenase (AmDH) from Jeotgalicoccus aerolatus for the direct asymmetric reductive amination of heteroaryl ketones. The engineered enzyme exhibited excellent conversions and enantioselectivities, even for ketones with bulky alkyl chains. Directed evolution based on molecular docking was used to enhance the enzyme's activity by enlarging the active pocket with a more hydrophobic entrance. The engineered enzyme was also applied in the synthesis of pharmaceutically relevant amines and a key intermediate of chiral pincer ligands.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Organic

Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates

Zhenwei Wu et al.

Summary: A new method for the catalytic asymmetric reductive amination of ketones with pinacolborane has been developed, using chiral SPINOL-derived borophosphates as catalysts. Good yields and high enantioselectivities of chiral amine derivatives were achieved under mild reaction conditions. The synthetic applicability of this method has been demonstrated by the asymmetric synthesis of (R)-Fendiline.

ORGANIC LETTERS (2022)

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Article Chemistry, Multidisciplinary

Synthesis of Axially Chiral Biaryls via Enantioselective Ullmann Coupling of ortho-Chlorinated Aryl Aldehydes Enabled by a Chiral 2,2′-Bipyridine Ligand

Saima Perveen et al.

Summary: The first nickel-catalyzed highly enantioselective reductive Ullmann coupling of ortho-chlorinated aryl aldehyde was achieved under mild reaction conditions using a chiral 2,2'-bipyridine ligand (+)-DTB-SBpy, resulting in the synthesis of axially chiral biphenyl or binaphthyl dials with high yields and enantioselectivities. The versatility of the products as common synthetic intermediates for diverse axially chiral ligands, catalysts, and functional molecules was demonstrated through short-step transformations. Additionally, this protocol enabled the concise and highly enantioselective formal total synthesis of biologically active natural products.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Nickel-Catalyzed Enantioconvergent Carboxylation Enabled by a Chiral 2,2';-Bipyridine Ligand

Linghua Wang et al.

Summary: A nickel-catalyzed general, efficient, and highly enantioselective carboxylation reaction of racemic benzylic (pseudo)halides has been developed, utilizing atmospheric CO2 under mild conditions. A unique chiral 2,2'-bipyridine ligand enabled both high reactivity and stereoselectivity.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Physical

Cycloiridated Helicenes as Chiral Catalysts in the Asymmetric Transfer Hydrogenation of Imines

Daisuke Sakamoto et al.

Summary: This study describes an asymmetric synthesis method for the preparation of optically pure and conformationally locked oxabenzo[5]helicenes. These compounds can be transformed into cycloiridated organometallics and exhibit excellent catalytic performance in asymmetric transfer hydrogenation reactions.

ACS CATALYSIS (2022)

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Article Chemistry, Multidisciplinary

Reductive aminations by imine reductases: from milligrams to tons

Amelia K. Gilio et al.

Summary: The synthesis of chiral amines through the reductive amination reaction is a significant reaction in synthetic chemistry, with applications in pharmaceutical and bioactive molecule synthesis. While transition metal catalysis is commonly used, biocatalytic methods have gained interest due to their selectivity and sustainability. The discovery of imine reductase and reductive aminase enzymes has paved the way for an industrial approach to chiral amine production, enabling scale-up from laboratory to ton-scale reactions.

CHEMICAL SCIENCE (2022)

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Review Chemistry, Applied

NAD(P)H-Dependent Enzymes for Reductive Amination: Active Site Description and Carbonyl-Containing Compound Spectrum

Laurine Ducrot et al.

Summary: The biocatalytic asymmetric synthesis of amines from carbonyl compounds and amine precursors represents a significant advancement in sustainable synthetic chemistry, offering advantages such as enhanced selectivity, stability, and substrate scope. Utilizing a combination of structure-informed protein engineering and natural genetic resources, various oxidoreductases have been identified to catalyze the reductive amination reaction. This approach demonstrates the potential for the industrial synthesis of chiral amines through the development of biocatalysts with improved activity and altered properties.

ADVANCED SYNTHESIS & CATALYSIS (2021)

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Article Engineering, Environmental

Continuous production of a chiral amine in a packed bed reactor with co-immobilized amine dehydrogenase and formate dehydrogenase

Robert D. Franklin et al.

Summary: A continuous flow packed bed reactor system was developed for asymmetric reductive amination using a chimeric amine dehydrogenase and formate dehydrogenase, achieving stable conversion and high volumetric productivities. The study examined the relationship between flow rate, conversion, and enzyme concentration, providing important insights for reaction engineering. This work represents the first stable application of AmDHs in a continuous flow reactor for the production of chiral amines.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

An Iridium Catalytic System Compatible with Inorganic and Organic Nitrogen Sources for Dual Asymmetric Reductive Amination Reactions

Zhaofeng Gao et al.

Summary: The research reports on efforts to merge two asymmetric reductive amination reactions into a single-step transformation, utilizing specific catalyst and acid additives to successfully synthesize enantiopure secondary amine products.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination

Peiyuan Yao et al.

Summary: In this study, a new stereoselective biocatalytic synthesis method for N-substituted alpha-amino esters was reported, utilizing diverse metagenomic imine reductases. Both enantiomers of the target products were synthesized with high conversion and excellent enantioselectivity under mild reaction conditions. Furthermore, over 20 different preparative scale transformations were performed, demonstrating the scalability of this system.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Physical

Does the Configuration at the Metal Matter in Noyori-Ikariya Type Asymmetric Transfer Hydrogenation Catalysts?

Andrew M. R. Hall et al.

Summary: This study reveals the existence of two diastereomeric hydride complexes under reaction conditions and their interconversion during transfer hydrogenation catalysis. Further computational analysis shows the differences in catalytic efficiency and stereoselectivity between different configurations.

ACS CATALYSIS (2021)

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Review Chemistry, Physical

Recent Progress in Transition-Metal-Catalyzed Asymmetric Reductive Amination

Noor U. Din Reshi et al.

Summary: Asymmetric reductive amination (ARA) is a concise and operationally simple method for the synthesis of chiral amines, where the process involves condensation of a carbonyl group with an amine/ammonia and enantioselective reduction of the generated intermediate. The use of a chiral transition metal catalyst facilitates the activation of reductant and stereoselective transfer of hydrogen to the intermediate imine/enamine. The research in this area has significantly advanced in recent years, with the development of highly efficient and general ARA methodologies for various challenging carbonyl and amine partners.

ACS CATALYSIS (2021)

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Article Chemistry, Physical

Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase

Dong-Hao Wang et al.

Summary: Engineered amine dehydrogenase GkAmDH has been evolved in the laboratory to broaden its substrate scope for reductive amination of an extensive set of ketones, particularly showing higher activity toward bulky ketones. Mutants M3 and M8 can synthesize bulky chiral amines with high conversion, high enantiomeric excess, and high turnover number, providing key chiral intermediates for drug synthesis with promising thermostability.

ACS CATALYSIS (2021)

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Article Chemistry, Multidisciplinary

Recent Development in the Synthesis and Catalytic Application of Iridacycles

Zhenyu Chen et al.

Summary: This article provides a brief review on the progress made in the synthesis and application of cyclometallated half-sandwich Cp*Ir(III) complexes since 2017, covering various types of ligands and their applications in catalysis.

CHEMICAL RECORD (2021)

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Article Chemistry, Physical

Development of a Tunable Chiral Pyridine Ligand Unit for Enantioselective Iridium-Catalyzed C-H Borylation

Peidong Song et al.

Summary: This study introduces a new tunable chiral pyridine framework, which is successfully applied in a highly selective iridium-catalyzed reaction with high yields. Experimental and theoretical investigations demonstrate the excellent performance of this framework, which can be used in the synthesis of chiral protonated compounds.

ACS CATALYSIS (2021)

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Review Chemistry, Organic

Recent advances on transition-metal-catalysed asymmetric reductive amination

Yingying Tian et al.

Summary: Transition-metal-catalysed asymmetric reductive amination is a direct method for accessing chiral amines, converting carbonyl compounds and ammonia or amines into drug-relevant compounds in one pot. Recent progress has been made in homogeneous transition-metal-catalysed ARA reactions with H-2 or other hydride sources, but challenges and potential still exist in this field.

ORGANIC CHEMISTRY FRONTIERS (2021)

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Article Chemistry, Organic

Chiral cyclometalated iridium complexes for asymmetric reduction reactions

Jennifer Smith et al.

Summary: A series of chiral cyclometalated iridium complexes were synthesized and studied for asymmetric transfer hydrogenation reactions using formic acid as the hydrogen source, showing different activities and enantioselectivities, with the most effective ones achieving up to 63% ee in asymmetric reductive amination of ketones and 77% ee in reduction of pyridinium ions.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2

Le'an Hu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

A Simple Biosystem for the High-Yielding Cascade Conversion of Racemic Alcohols to Enantiopure Amines

Kaiyuan Tian et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Chemistry, Multidisciplinary

Transition-Metal-Catalyzed Reductive Amination Employing Hydrogen

Torsten Irrgang et al.

CHEMICAL REVIEWS (2020)

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Article Multidisciplinary Sciences

Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines

Josep Mas-Rosello et al.

SCIENCE (2020)

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Article Chemistry, Physical

Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination

Zefei Xu et al.

ACS CATALYSIS (2020)

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Article Chemistry, Physical

Dynamic Kinetic Asymmetric Amination of Alcohols Assisted by Microwave: Stereoconvergent Access to Tetralin- and Indane-Derived Chiral Amines

Zi-Qiang Rong et al.

ACS CATALYSIS (2020)

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Review Chemistry, Multidisciplinary

Catalytic reductive aminations using molecular hydrogen for synthesis of different kinds of amines

Kathiravan Murugesan et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Chemistry, Physical

Iridium-catalyzed enantioselective reductive amination of aromatic ketones

Ruixia Liu et al.

CATALYSIS SCIENCE & TECHNOLOGY (2020)

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Review Chemistry, Multidisciplinary

Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis

Pei Tang et al.

GREEN SYNTHESIS AND CATALYSIS (2020)

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Article Chemistry, Physical

Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines

Lei Liu et al.

CATALYSIS SCIENCE & TECHNOLOGY (2020)

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Article Chemistry, Organic

Chiral Bronsted Acid-Catalyzed Metal-Free Asymmetric Direct Reductive Amination Using 1-Hydrosilatrane

Vladislav Skrypai et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Z-bpy, a New C2-Symmetric Bipyridine Ligand and Its Application in Enantioselective Copper(I)-Catalyzed Cyclopropanation of Olefins

Yizhao Ouyang et al.

CHINESE JOURNAL OF CHEMISTRY (2019)

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Review Chemistry, Multidisciplinary

Reductive Amination in the Synthesis of Pharmaceuticals

Oleg Afanasyev et al.

CHEMICAL REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Catalytic Biomimetic Asymmetric Reduction of Alkenes and Imines Enabled by Chiral and Regenerable NAD(P)H Models

Jie Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Secondary amines as coupling partners in direct catalytic asymmetric reductive amination Electronic supplementary information (ESI) available: Procedures and spectra.

Zitong Wu et al.

CHEMICAL SCIENCE (2019)

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Article Chemistry, Physical

A family of native amine dehydrogenases for the asymmetric reductive amination of ketones

Ombeline Mayol et al.

NATURE CATALYSIS (2019)

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Article Chemistry, Multidisciplinary

Direct Asymmetric Ruthenium-Catalyzed Reductive Amination of Alkyl-Aryl Ketones with Ammonia and Hydrogen

Joan Gallardo-Donaire et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Multidisciplinary

Asymmetric Transfer and Pressure Hydrogenation with Earth-Abundant Transition Metal Catalysts

Zhenfeng Zhang et al.

CHINESE JOURNAL OF CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H-2

Xuefeng Tan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Article Chemistry, Physical

Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines

Fei-Fei Chen et al.

ACS CATALYSIS (2018)

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Article Chemistry, Multidisciplinary

Dynamic Kinetic Asymmetric Reductive Amination: Synthesis of Chiral Primary beta-Amino Lactams

Yazhou Lou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Chemistry, Applied

Enantioselective Synthesis of beta-Aminotetralins via Chiral Phosphoric Acid-catalyzed Reductive Amination of beta-Tetralones

Do Young Park et al.

ADVANCED SYNTHESIS & CATALYSIS (2018)

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Article Chemistry, Multidisciplinary

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

Lia Martinez-Montero et al.

GREEN CHEMISTRY (2017)

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Article Chemistry, Organic

Direct Catalytic Asymmetric Reductive Amination of Aliphatic Ketones Utilizing Diphenylmethanamine as Coupling Partner

Haizhou Huang et al.

ORGANIC LETTERS (2017)

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Article Chemistry, Physical

Understanding and Overcoming the Limitations of Bacillus badius and Caldalkalibacillus thermarum Amine Dehydrogenases for Biocatalytic Reductive Amination

Ahir Pushpanath et al.

ACS CATALYSIS (2017)

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Review Chemistry, Physical

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

Iustina Slabu et al.

ACS CATALYSIS (2017)

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Article Chemistry, Physical

Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox

Gheorghe-Doru Roiban et al.

CHEMCATCHEM (2017)

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Review Chemistry, Applied

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application

Mahima Sharma et al.

ADVANCED SYNTHESIS & CATALYSIS (2017)

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Article Chemistry, Multidisciplinary

Remarkable Differences in Reactivity between Benzothiazoline and Hantzsch Ester as a Hydrogen Donor in Chiral Phosphoric Acid Catalyzed Asymmetric Reductive Amination of Ketones

Kyung-Hee Kim et al.

CHEMISTRY-AN ASIAN JOURNAL (2016)

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Article Chemistry, Multidisciplinary

Nickel-Catalyzed Enantioselective Reductive Amination of Ketones with Both Arylamines and Benzhydrazide

Peng Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Chemistry, Multidisciplinary

Direct Asymmetric Reductive Amination for the Synthesis of Chiral -Arylamines

Haizhou Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Chemistry, Multidisciplinary

Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

Keiji Mori et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Chemistry, Organic

Chiral Phosphoric Acid-Catalyzed Enantioselective Reductive Amination of 2-Pyridyl Ketones: Construction of Structurally Chiral Pyridine-Based Ligands

Abulikemu Abudu Rexit et al.

JOURNAL OF ORGANIC CHEMISTRY (2016)

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Review Chemistry, Multidisciplinary

Imino Transfer Hydrogenation Reductions

Martin Wills

TOPICS IN CURRENT CHEMISTRY (2016)

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Review Chemistry, Applied

Biocatalytic Imine Reduction and Reductive Amination of Ketones

Joerg H. Schrittwieser et al.

ADVANCED SYNTHESIS & CATALYSIS (2015)

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Article Chemistry, Physical

Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones

Philipp N. Scheller et al.

CHEMCATCHEM (2015)

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Article Chemistry, Multidisciplinary

Iridicycle-Catalysed Imine Reduction: An Experimental and Computational Study of the Mechanism

Hsin-Yi Tiffany Chen et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

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Article Chemistry, Organic

Enantioselective Synthesis of β-Arylamines via Chiral Phosphoric Acid-Catalyzed Asymmetric Reductive Amination

Kyung-Hee Kim et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

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Article Chemistry, Organic

Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen

Anja K. Holzer et al.

ORGANIC LETTERS (2015)

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Article Chemistry, Organic

Asymmetric Synthesis of α-Amino Ketones by Bronsted Acid Catalysis

Wei Wen et al.

ORGANIC LETTERS (2015)

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Article Chemistry, Physical

Engineering of Amine Dehydrogenase for Asymmetric Reductive Amination of Ketone by Evolving Rhodococcus Phenylalanine Dehydrogenase

Li Juan Ye et al.

ACS CATALYSIS (2015)

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Review Biochemistry & Molecular Biology

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

Hannes Kohls et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2014)

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Article Chemistry, Multidisciplinary

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

Michael J. Abrahamson et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Article Chemistry, Multidisciplinary

Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

Kodai Saito et al.

CHEMICAL COMMUNICATIONS (2012)

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Review Chemistry, Multidisciplinary

Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

Jian-Hua Xie et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Article Chemistry, Multidisciplinary

Multiwfn: A multifunctional wavefunction analyzer

Tian Lu et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2012)

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Review Chemistry, Multidisciplinary

Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines

Jian-Hua Xie et al.

CHEMICAL REVIEWS (2011)

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Review Chemistry, Applied

Chiral Amine Synthesis - Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

Thomas C. Nugent et al.

ADVANCED SYNTHESIS & CATALYSIS (2010)

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Article Chemistry, Multidisciplinary

Catalytic Asymmetric Reductive Amination of alpha-Branched Ketones

Vijay N. Wakchaure et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

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Article Chemistry, Multidisciplinary

A Versatile Catalyst for Reductive Amination by Transfer Hydrogenation

Chao Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

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Article Chemistry, Multidisciplinary

Organocatalytic Asymmetric Synthesis of trans-1,3-Disubstituted Tetrahydroisoquinolines via a Reductive Amination/Aza-Michael Sequence

Dieter Enders et al.

CHEMISTRY-A EUROPEAN JOURNAL (2010)

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Article Biochemical Research Methods

Biocatalytic asymmetric amination of carbonyl functional groups - a synthetic biology approach to organic chemistry

Dunming Zhu et al.

Biotechnology Journal (2009)

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Article Chemistry, Multidisciplinary

Direct Asymmetric Reductive Amination

Dietrich Steinhuebel et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

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Article Chemistry, Multidisciplinary

Metal-Bronsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

Chaoqun Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

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Article Chemistry, Multidisciplinary

Formal Asymmetric Biocatalytic Reductive Amination

Dominik Koszeleivski et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

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Article Chemistry, Multidisciplinary

Catalytic asymmetric reductive amination of aldehydes via dynamic kinetic resolution

Sebastian Hoffmann et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

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Article Chemistry, Multidisciplinary

Enantioselective organocatalytic reductive amination

RI Storer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

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Article Chemistry, Multidisciplinary

A powerful bronsted acid catalyst for the organocatalytic asymmetric transfer hydrogenation of imines

S Hoffmann et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

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Review Chemistry, Multidisciplinary

Industrial methods for the production of optically active intermediates

M Breuer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)

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Article Chemistry, Multidisciplinary

Highly enantioselective hydrogen-transfer reductive amination: Catalytic asymmetric synthesis of primary amines

R Kadyrov et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)

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Additive-Free Transfer Hydrogenative Direct Asymmetric Reductive Amination Using a Chiral Pyridine-Derived Half-Sandwich Catalyst

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