期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 27, 页码 8348-8351出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b04061
关键词
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资金
- University of Vienna
- ERC [StG 278872]
- FAT [P27194]
- Austrian Science Fund (FWF) [P27194] Funding Source: Austrian Science Fund (FWF)
The synthesis of alpha-amino carbonyl/carboxyl compounds is a contemporary challenge in organic synthesis. Herein, we present a stereoselective alpha-amination of amides employing simple azides that proceeds under mild conditions with release of nitrogen gas. The amide is used as the limiting reagent, and through simple variation of the azide pattern, various differently substituted aminated products can be obtained. The reaction is fully chemoselective for amides even in the presence of esters or ketones and lends itself to preparation of optically enriched products.
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