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Article
Acoustics
Lin Du et al.
Summary: A strategy combining ultrasound and nanomaterial was designed to enhance the ECL signal of the luminol-O2 system. Ultrasound pretreatment generated ROS in situ and triggered the ECL signal, while 1T/2H MoS2 catalyzed the oxidation of luminol and further enhanced the ECL response. The ECL biosensor, combined with catalytic DNA assembly, showed excellent performance for the detection of miRNA-155 with a detection limit of 0.057 fM.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiangfu Hu et al.
Summary: In this study, we demonstrate the diffusion-induced acceleration of charge transfer from Ru(bpy)32+-doped silica nanoparticles (RDSNs) to the electrode via electrochemiluminescence (ECL) imaging. The presence of Ru(bpy)32+ in the electrolyte enhances the ECL emission of RDSNs, and the emission intensity is amplified by 478 times when the free Ru(bpy)32+ concentration is 10 μM. The diffusion of Ru(bpy)33+ near a single RDSN enables faster charge transfer to the electrode than electron hopping in RDSN, as demonstrated by spatial and temporal interaction imaging of the RDSN and the Ru(III) diffusion layer.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Sara Knezevic et al.
Summary: Electrochemiluminescence (ECL) microscopy is a new technique used for imaging single entities and cells. In this study, a bimodal and bicolor approach was developed to record both positive ECL (PECL) and shadow label-free ECL (SECL) images of single cells. This dual approach enables the imaging of cell morphology and can contribute to multimodal ECL imaging and bioassays.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuan Zhou et al.
Summary: Rapid and accurate identification of pathogens is essential for public healthcare and patient treatment. However, current analytic tools are expensive or time-consuming. In this study, we introduce electrochemiluminescence (ECL) microscopy to image and identify single bacteria with high precision. Direct bacterial counting and classification with an accuracy of up to 90.5% is achieved. Our work demonstrates that ECL microscopy offers a powerful quantitative imaging methodology for bacterial characterization.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Acoustics
Huixin Zhang et al.
Summary: The low electrogenerated chemiluminescence (ECL) of air-saturated luminol is greatly improved by utilizing the synergistic effects of Ti3C2-TiO2-AuNPs nano hybrid and high-intensity focused ultrasound pretreatment. The ultrasound-pretreatment generates O2(-center dot) and H2O2 as initiators, and the decorated TiO2 and Au nanoparticles on the Ti3C2 surface catalyze and aggregate H2O2 to O-2(-center dot). The sensitivity of detecting exosomes in biological samples is significantly enhanced by the ECL sensor with a detection limit of 195 particles mu L-1. We believe that the ultrasound-pretreatment strategy can be extended for sensitive detection in biological samples.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Zhihao Wei et al.
Summary: In this study, a highly sensitive luminol-O2 ECL system was constructed using high-intensity focused ultrasound (HIFU) pretreatment combined with Ti3C2-TiO2 for the specific detection of polynucleotide kinase (PNK). HIFU generated reactive oxygen species (ROS) in situ through the cavitation effect, boosting the luminol emission. Ti3C2-TiO2 was prepared in situ via Ti3C2 as a reducing agent and can aggregate and catalyze the ROS generated by HIFU. Moreover, the Ti on the Ti3C2-TiO2 surface can bind to phosphate groups, enabling highly specific detection of PNK. The sensor has a linear range of 1.0 x 10-5 to 10.0 U mL-1 and a detection limit of 1.48 x 10-7 U mL-1, surpassing most existing methods.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yuling Wang et al.
Summary: This study demonstrates the successful visualization and recognition of KDM1/LSD1 antigen in a single cell using wireless bipolar electrochemiluminescence (BPE-ECL), solving the challenge of intracellular wireless visualization.
Article
Chemistry, Analytical
Fatma Ben Trad et al.
Summary: The characterization of release events from liposomes has been quantitatively addressed using an electro-chemiluminescence (ECL) imaging strategy. By combining amperometry, epifluorescence imaging, and ECL imaging, the opening of liposomes and the subsequent release of their content can be monitored and imaged. This approach offers advantages over traditional techniques and is suitable for studying membrane rupture/permeation events.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Huiwen Xiong et al.
Summary: This study proposed an ECL immunosensor based on localized surface plasmon resonance (LSPR) for the determination of pancreatic cancer exosomes, showing a wide calibration range and high selectivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jinrun Dong et al.
Summary: Here, we demonstrate super-resolution imaging of Ru(bpy)(3)(2+) reactions on Au plates using single-molecule electrochemiluminescence microscopy, achieving high spatial resolution and sensitivity to single photons. The spatiotemporally resolved dynamic structure-activity relationship on Au plates reveals the importance of catalyst restructuring in determining reactivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ming-Ming Chen et al.
Summary: We report a photodynamic therapy driven by electrochemiluminescence (ECL) with potential clinical applications. The ECL-generated luminescence acts as both optical readout and light source for the excitation of photosensitizer to produce reactive oxygen species (ROS). Real-time monitoring of cellular processes during ECL-PDT was achieved using ECL microscopy with high spatiotemporal resolution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Li Ding et al.
Summary: In this work, a novel multiplexed immunassay for simultaneous and fast analysis of cancer markers was developed by combining previous developed surface-enhanced electrochemiluminescence (SEECL) with a bioimaging device. A core-shell nanocomposite consisting of gold-silicon dioxide nanoparticles doped with Ru(bpy)(3)(2+) was employed as ECL label, which could significantly enhance the ECL emission of Ru(bpy)(3)(2+) due to the localized surface plasmon resonance (LSPR) of AuNPs. The proposed SEECL strategy showed high sensitivity, fast analysis, and high-throughput platform for clinical diagnosis of cancer markers in exhaled breath condensates (EBCs).
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhuanzhuan Wang et al.
Summary: In recent years, semiconducting polymer dots (Pdots) have attracted intense attention in ECL biosensing and imaging as environmentally friendly and high-brightness nanoemitters. However, the high ECL excitation potential of most available Pdots in the aqueous phase leads to poor selectivity in sample detection. This work demonstrates a simple and universal strategy to lower the trigger potential of Pdots based on electrochemiluminescence resonance energy transfer (ERET). The low potential Pdots showed excellent performance in glucose imaging detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiao-Yan Wang et al.
Summary: In this study, a novel near-infrared electrochemiluminescence signal amplification strategy based on SiO2 photonic crystals nanomembrane was developed for sensitive and specific detection of SFTSV. The SiO2 photonic crystal structure demonstrated excellent light scattering effect and increased effective electroactive area, leading to significant improvement in ECL intensity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Lurong Ding et al.
Summary: This work presents a surface-sensitive imaging methodology for evaluating cell-matrix adhesion differences at the single cell level and analyzing the impact of the chemical microenvironment on cell behaviors. The study reveals that different surface modifications lead to varying strengths of cell-matrix adhesion, and specific integrin subunits exhibit selective recognition to different surfaces.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Huixin Zhang et al.
Summary: In this study, high-intensity focused ultrasound (HIFU) was introduced as a pretreatment method to enhance the electrochemiluminescence (ECL) signal of luminol without the need for exogenous co-reactants. The in situ generation of superoxide anion (O-2(-center dot)) by HIFU was found to be the key initiator for boosting the ECL emission, providing a promising strategy for ultrasensitive ECL detection in the analysis of complex biological entities.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Zhichen Zhang et al.
Summary: Electrochemiluminescence microscopy (ECLM) is an emerging visualization tool that allows direct study of the morphological structures and functional characteristics of cells. Compared to other imaging methods, ECLM has advantages such as low optical background, high sensitivity, simple instrumentation, and surface-confined mode.
Article
Chemistry, Multidisciplinary
Julie Descamps et al.
Summary: This study reports the first example of anti-Stokes photoinduced electrochemiluminescence (PECL) with the model [Ru(bpy)(3)](2+)/benzoyl peroxide system at a bare p-type Si photocathode. The reported PECL system allows a notable decrease of the cathodic potential required for ECL generation and opens up new opportunities for imaging and light-addressable devices.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Weiliang Guo et al.
Summary: The study utilized microtube electrode (MTE) and microscopy to measure the thickness of ECL layer (TEL) in order to decipher reaction mechanisms. Different systems exhibited varying changes in ECL pattern and TEL, with the catalytic route playing a significant role in these variations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Peilin Wang et al.
Summary: This study focused on constructing a nanomaterial-patterned structure for high-resolved ECL signal modulation and designing a polarization-resolved ECL biosensor for detecting breast cancer patients. The self-assembled Au NT-based patterned structures showed significant hot spot regions, leading to directional ECL emission. The biosensor achieved good quantitative detection in a linear range of 1 fM to 1 nM and showed satisfactory results in the analysis of triple-negative breast cancer patients' serum.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Chengda Meng et al.
Summary: A new type of apertureless USB piezoelectric ultrasonic transducer has been designed, which can induce intense sonochemiluminescence and enable sensitive detection of hydrogen peroxide. By using this device, a visual hydrogen peroxide detection method has been established, as well as the detection of glucose oxidase activity and glucose. The inexpensive and user-friendly nature of this apertureless device makes it promising for sonochemistry applications and chemical education.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dongni Han et al.
Summary: Electrochemiluminescence (ECL) microscopy is successfully used for imaging cells, micro-/nano-objects, and electrochemical processes. The decrease of ECL signal during successive image recordings is a key limitation for ECL microscopy development. An electrochemical approach involving cathodic regenerative treatment can restore the ECL signal intensity, allowing for continuous image recording without signal loss.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Cheng Ma et al.
Summary: The bio-coreactant-enhanced electrochemiluminescence (ECL) microscopy allows for ECL imaging of intracellular structure and dynamic transport by using Ru(bpy)(3)(2+) and intracellular biomolecules. The research reveals the universal edge effect of cellular electroporation, as well as the dynamic transport of Ru(bpy)(3)(3+) in different cellular compartments and its correlation with the actin cytoskeleton.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biophysics
Qingqing Huang et al.
Summary: Ru-PEI-L-lys was immobilized on ZIF-8 to form Ru-PEI-L-lys-ZIF-8, which was then mixed with PtNPs to enhance the ECL response. The combination of selective aptamer and RecJf exonuclease in the system resulted in a highly sensitive ECL biosensor for thrombin detection, with a linear response range from 1 fM to 10 pM and a detection limit of 0.02 aM. This work presents a new strategy for designing stable ECL indicators and developing sensitive ECL sensors for biological analysis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Hao Ding et al.
Summary: A novel method for spatially selective imaging of cell junctions by regulating the thickness of the electrochemiluminescence (ECL) layer through control of luminophore and co-reactant concentrations has been reported. Low luminophore concentration reveals cell-matrix adhesions, while high concentration allows sequential imaging of cell-matrix and cell-cell junctions. This strategy not only provides new insights into ECL mechanisms but also expands the potential applications of ECL microscopy in bioimaging.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yujie Liu et al.
Summary: This study successfully imaged single biomolecules using RuDSNs/AuNPs as ECL nanoemitters, demonstrating the visualization of single protein molecules and single membrane proteins in cells, overcoming the challenges in ultrasensitive ECL analysis and providing valuable information for cellular biology research.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Electrochemistry
Haidong Li et al.
Summary: The study demonstrates the fabrication of microwell bipolar electrode arrays (MBEA) to enhance electrochemiluminescence (ECL) emission, resulting in a bell-like ECL emission with higher light intensity at the center. Theoretical simulations reveal that the parabolic-shaped bottom of the microwell induces strong overlapped diffusion fields in its center, promoting the generation of ECL.
Article
Chemistry, Analytical
Zihui Liang et al.
Summary: A novel multiplex electrochemiluminescence polarization assay was developed to detect breast cancer-related genes BRCA1 and BRCA2 simultaneously. The study revealed the relation between the structure of metal nanomaterials and SPC-ECL, and a high polarization-resolved sensing system was designed to detect multitarget DNA. Polarization-based multiple ECL analysis has broad prospects in related cancer diagnosis and treatment evaluation.
ANALYTICAL CHEMISTRY
(2021)
Article
Physics, Applied
Kenki Tsukahara et al.
Summary: In this study, HIFU was used to generate and oscillate cavitation bubbles for ROS generation in SDT treatment. Adjusting the intensity and interval of HIFU exposure showed that a sequence with 300 ms interval and 0.25 kW cm(-2) burst-wave intensity improved the energy efficiency of ROS generation.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2021)
Article
Chemistry, Analytical
Qiuxia Hao et al.
Summary: An ECL microRNA biosensor was developed using anti-fouling MBs and two signal amplification strategies. The designed anti-fouling dendritic peptide on MBs resisted nonspecific adsorption in biological samples for accurate target recognition. The biosensor demonstrated ultra-high sensitivity and excellent selectivity for miRNA 21 detection, with a detection limit of 0.13 fM, and was capable of assaying targets in complex biological media such as serum and cell lysate.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yumeng Ma et al.
Summary: This study introduces a label-free shadow electrochemiluminescence (ECL) microscopy technique to image single living mitochondria deposited on electrode surface. By utilizing negative optical contrast and local diffusional hindrance, this approach visualizes individual mitochondria and validates their functionality with classical fluorescent biomarkers. The versatility and extreme sensitivity of this method make it promising for imaging subcellular structures while alleviating photobleaching and phototoxicity issues associated with conventional microscopy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hui Zhu et al.
Summary: By mapping the electrocatalytic activity of a single graphene sheet with nanometer resolution using electrochemiluminescence (ECL) microscopy, this study effectively avoids the problem of overlapping ECL emissions from adjacent regions and achieves nanometer spatial resolution for the first time. The varied adsorption of hydrogen peroxide on the graphene surface leads to unsynchronized ECL emission, allowing the ECL intensity of each pixel to reflect the electrocatalytic features of the graphene surface with a resolution of 400 nm.
Review
Chemistry, Analytical
Yue Cao et al.
Summary: Sensitive and accurate detection of biological analytes is crucial in life science field. Signal amplification, mainly through DNA technology, has been widely integrated into the construction of electrochemiluminescence (ECL) biosensors. This approach has brought desirable analytical performance in clinical diagnosis, biomedical research, and drug development.
JOURNAL OF ANALYSIS AND TESTING
(2021)
Article
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(2019)
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(2019)
Article
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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(2018)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
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Article
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Jingjing Xue et al.
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(2017)
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(2015)
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2002)
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JOURNAL OF PHYSICAL CHEMISTRY A
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