4.8 Article

Three-Dimensional Magnetic Chip with Extracorporeal Circulation for Circulating Tumor Cell In Vivo Detection and Tumor Growth Inhibition

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ANALYTICAL CHEMISTRY
卷 95, 期 22, 页码 8735-8743

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AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.3c01753

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Liquid biopsy technology involves minimally invasive sampling of body fluids to analyze tumor markers for early tumor diagnosis and efficacy evaluation. This study presents a 3D magnetic chip-based extracorporeal circulation system for in vivo detection and real-time monitoring of circulating tumor cells (CTCs). By utilizing biofunctionalized magnetic nanospheres (MNs) with CTC recognition function, this 3DMC system enables efficient real-time monitoring of CTCs with good stability and strong anti-interference. In vivo detection not only detects more CTCs compared to in vitro detection but also identifies CTCs at an early stage of tumor presence in the blood. With its flexible chip design, the system can easily integrate cancer diagnosis and treatment. The biocompatibility and stability of the 3DMC system make it a promising tool for personalized medical programs for cancer patients.
Liquidbiopsy technology involves taking samples frombody fluidsin a minimally invasive way and analyzing tumor markers to achieveearly diagnosis and efficacy evaluation of tumors. The developmentof real-time cancer diagnosis and treatment strategies based on liquidbiopsy technology is of great significance to cancer management. Thispaper described an extracorporeal circulation based on a three-dimensional(3D) magnetic chip (3DMC-system) for in vivo detection and real-timemonitoring of circulating tumor cells (CTCs). Utilizing biofunctionalizedmagnetic nanospheres (MNs) with CTC recognition function, this 3DMC-systemcould effectively achieve the real-time monitoring of CTCs in vivowith good stability and strong anti-interference. Compared with invitro CTC detection, in vivo detection could not only detect moreCTCs but also detect the presence of CTCs in the blood at an earlystage of the tumor, when tumor metastasis is not observed in imaging.In addition, due to the flexibility of the chip design, the systemcan easily add a treatment module to integrate cancer diagnosis andtreatment together. With good biocompatibility and high stability,this 3DMC-system is expected to provide a new personalized medicalprogram for cancer patients.

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