Reference material development for detection of human respiratory syncytial virus using digital PCR

Review Microbiology

Going Viral-RSV as the Neglected Adult Respiratory Virus

Bethany Busack et al.

Summary: Human respiratory syncytial virus (RSV) is an important viral pathogen in adults, particularly in the elderly, immunocompromised individuals, and those with underlying cardiopulmonary disease. Its true burden of disease in adults may be significantly underestimated, despite being recognized as one of the most common causes of upper respiratory tract infections in children. The emerging evidence of RSV's role in morbidity and mortality in elderly and immunocompromised patients has led to advancements in vaccine development and renewed interest in quantifying the disease burden.

PATHOGENS (2022)

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Review Infectious Diseases

Global Coinfections with Bacteria, Fungi, and Respiratory Viruses in Children with SARS-CoV-2: A Systematic Review and Meta-Analysis

Saad Alhumaid et al.

Summary: Coinfection with bacteria, fungi, and respiratory viruses increases the severity of COVID-19 in children. The most common virus identified in children with COVID-19 is RSV, and the most common bacterium is Mycoplasma pneumonia. Understanding bacterial, fungal, and respiratory viral coinfections has potential diagnostic and treatment implications in COVID-19 children.

TROPICAL MEDICINE AND INFECTIOUS DISEASE (2022)

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Article Immunology

Risk Factors and Medical Resource Utilization of Respiratory Syncytial Virus, Human Metapneumovirus, and Influenza-Related Hospitalizations in Adults-A Global Study During the 2017-2019 Epidemic Seasons (Hospitalized Acute Respiratory Tract Infection [HARTI] Study)

Ann R. Falsey et al.

Summary: The study demonstrates that in hospitalized adults, patients infected with respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) have more underlying risk factors and medical resource utilization compared to those with influenza, indicating a need for effective interventions.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Biochemical Research Methods

Rapid detection of human respiratory syncytial virus A and B by duplex real-time RT-PCR

Angela K. Todd et al.

Summary: Respiratory syncytial virus (RSV) is a common cause of acute respiratory disease, especially in young children. The World Health Organization (WHO) has initiated an RSV Surveillance Pilot program which developed a duplex real-time RT-PCR assay for simultaneous detection of RSV A and B subtypes. This assay is highly specific for RSV, without cross-reactivity with other respiratory pathogens.

JOURNAL OF VIROLOGICAL METHODS (2021)

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Article Multidisciplinary Sciences

Genetic diversity and molecular evolution of human respiratory syncytial virus A and B

Jie-Mei Yu et al.

Summary: This study analyzed the genetic variability and evolutionary pattern of human respiratory syncytial viruses (RSVs) from 1977 to 2019, revealing different evolutionary rates and population size dynamics between RSV-A and RSV-B. The high occurrence rate of single nucleotide polymorphisms (SNPs) in the G gene and the sharp population expansion of RSV-B since 2005 were notable findings. Such insights could be valuable for informing vaccine and therapy strategies against RSV infection.

SCIENTIFIC REPORTS (2021)

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Article Medical Laboratory Technology