期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 29, 页码 9093-9096出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b05779
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资金
- University of Geneva
- European Research Council (ERC)
- Swiss National Centre of Competence in Research (NCCR) Chemical Biology
- NCCR Molecular Systems Engineering
- Swiss NSF
In this report, we introduce synthetic anion transporters that operate with chalcogen bonds. Electron deficient dithieno[3,2-b;2',3'-d]thiophenes (DTTs) are identified as ideal to bind anions in the focal point of the a holes on the cofacial endocyclic sulfur atoms. Anion binding in solution and anion transport across lipid bilayers are found to increase with the depth of the sigma holes of the DTT anionophores. These results introduce DTTs and related architectures as a privileged motif to engineer chalcogen bonds into functional systems, complementary in scope to classics such as 2,2'-bipyrroles or 2,2'-bipyridines that operate with hydrogen bonds and lone pairs, respectively.
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