期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 29, 页码 9097-9100出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b05787
关键词
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资金
- Northeastern University
- NEU-DFCI
- NSF [1453255]
Negatively charged nucleic acids are often complexed with polycationic transfection agents before delivery. Herein, we demonstrate that a noncationic, biocompatible polymer, polyethylene glycol, can be used as a transfection vector by forming a brush polymer-DNA conjugate. The brush architecture provides embedded DNA strands with enhanced nuclease stability and improved cell uptake. Because of the biologically benign nature of the polymer component, no cytotoxicity was observed. This approach has the potential to address several long-lasting challenges in oligonucleotide therapeutics.
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