期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 138, 期 25, 页码 7808-7811出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b03221
关键词
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资金
- European Research Council under the European Union [665951 - ELICOS]
- Deutsche Forschungsgemeinschaft
- research training group (Graduiertenkolleg) [1626]
- Alexander von Humboldt Foundation
In the presence of a chiral thioxanthone catalyst (10 mol %) the title compounds underwent a clean intermolecular [2 + 2] photocycloaddition with electron-deficient olefins at lambda = 419 nm. The reactions not only proceeded with excellent regio- and diastereoselectivity but also delivered the respective cyclobutane products with significant enantiomeric excess (up to 95% ee). Key to the success of the reactions is a two-point hydrogen bonding between quinolone and catalyst enabling efficient energy transfer and high enantioface differentiation. Preliminary work indicated that solar irradiation can be used for this process and that the substrate scope can be further expanded to isoquinolones.
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